A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and Increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme

International Journal of Surgical Pathology - Tập 14 Số 3 - Trang 247-251 - 2006
Giuseppe Pelosi1, Francesco Petrella2, Maria Teresa Sandri1, Lorenzo Spaggiari, Domenico Galetta2, Giuseppe Viale1
1Divisions of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy.
2Division of Thoracic Surgery, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy

Tóm tắt

Malignant extragonadal germ cell tumors primary to the lung are quite uncommon lesions, but pure yolk sac tumor is even more exceptional. This is believed to be the first reported case of yolk sac tumor of the lung in which an intense and diffuse immunoreactivity for CDX2, a marker of intestinal differentiation reportedly expressed also in gonadal yolk sac tumor, was associated with increased serum levels of the alkaline phosphatase intestinal isoform. Nine months after radical surgery and adjuvant chemotherapy, the patient is alive and well without evidence of recurrent or metastatic disease and with serum levels of the alkaline phosphatase intestinal isoform within normal limits. The pathologist should be aware of yolk sac tumor arising in the lung and that alkaline phosphatase intestinal isoform could become an additional serum marker for such a tumor.

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Thông tin
Thông tin xuất bản

International Journal of Surgical Pathology

Tập 14 Số 3

247-251

Thông tin tác giả