A Practical Workflow for Magnetic Resonance–Guided Stereotactic Body Radiation Therapy to the Pancreas

Hammel, 2016, Effect of chemoradiotherapy vs chemotherapy on survival in patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine with or without erlotinib: The LAP07 randomized clinical trial, JAMA Oncol, 315, 1844, 10.1001/jama.2016.4324 Katz, 2021, Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX plus hypofractionated radiation therapy (RT) for borderline resectable (BR) adenocarcinoma of the pancreas, J Clin Oncol, 39, 377, 10.1200/JCO.2021.39.3_suppl.377 Versteijne, 2020, Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: Results of the Dutch randomized phase III PREOPANC trial, J Clin Oncol, 38, 1763, 10.1200/JCO.19.02274 Reyngold, 2021, Association of ablative radiation therapy with survival among patients with inoperable pancreatic cancer, JAMA Oncol, 7, 735, 10.1001/jamaoncol.2021.0057 Hassanzadeh, 2021, Ablative five-fraction stereotactic body radiation therapy for inoperable pancreatic cancer using online mr-guided adaptation, Adv Radiat Oncol, 6 Crane, 2017, Ablative radiotherapy doses for locally advanced: pancreatic cancer (LAPC), Cancer J, 23, 350, 10.1097/PPO.0000000000000292 Yang, 2014, Adequacy of inhale/exhale breathhold CT based ITV margins and image-guided registration for free-breathing pancreas and liver SBRT, Radiat Oncol, 9, 11, 10.1186/1748-717X-9-11 Bernard, 2020, Pancreas SBRT: Who, what, when, where, and how…, Pract Radiat Oncol, 10, 183, 10.1016/j.prro.2019.11.005 Chuong, 2013, Stereotactic body radiation therapy for locally advanced and borderline resectable pancreatic cancer is effective and well tolerated, Int J Radiat Oncol Biol Phys, 86, 516, 10.1016/j.ijrobp.2013.02.022 Boldrini, 2019, Online adaptive magnetic resonance guided radiotherapy for pancreatic cancer: State of the art, pearls and pitfalls, Radiat Oncol, 14, 71, 10.1186/s13014-019-1275-3 Henke, 2018, Phase I trial of stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of oligometastatic or unresectable primary malignancies of the abdomen, Radiother Oncology, 126, 519, 10.1016/j.radonc.2017.11.032 Chuong, 2021, Ablative 5-fraction stereotactic magnetic resonance-guided radiation therapy with on-table adaptive replanning and elective nodal irradiation for inoperable pancreas cancer, Pract Radiat Oncol, 11, 134, 10.1016/j.prro.2020.09.005 Rudra, 2019, Using adaptive magnetic resonance image-guided radiation therapy for treatment of inoperable pancreatic cancer, Cancer Med, 8, 2123, 10.1002/cam4.2100 Michalet, 2022, Stereotactic MR-guided radiotherapy for pancreatic tumors: Dosimetric benefit of adaptation and first clinical results in a prospective registry study, Front Oncol, 12, 10.3389/fonc.2022.842402 Tchelebi, 2020, Reducing the toxicity of radiotherapy for pancreatic cancer with magnetic resonance-guided radiotherapy, Toxicol Sci, 175, 19, 10.1093/toxsci/kfaa021 Linkowski, 2021, Improving the MR-guided radiotherapy patient experience through story driven video with 3D animations, Int J Radiat Oncol Biol Phys, 111, e19, 10.1016/j.ijrobp.2021.05.172 Hill, 2022, Location, location, location: What should be targeted beyond gross disease for localized pancreatic ductal adenocarcinoma (PDAC)? Proposal of a standardized clinical tumor volume (CTV) for PDAC of the head: The "Triangle Volume, Pract Radiat Oncol, 12, 215, 10.1016/j.prro.2022.01.005 Kharofa, 2019, Pattern of marginal local failure in a phase II trial of neoadjuvant chemotherapy and stereotactic body radiation therapy for resectable and borderline resectable pancreas cancer, Amer J Clin Onco, 42, 247, 10.1097/COC.0000000000000518 Palta, 2019, Radiation therapy for pancreatic cancer: Executive summary of an ASTRO clinical practice guideline, Pract Radiat Oncol, 9, 322, 10.1016/j.prro.2019.06.016 Brunner, 2021, ESTRO ACROP guidelines for target volume definition in pancreatic cancer, Radiother Oncol, 154, 60, 10.1016/j.radonc.2020.07.052 Jethwa KR, Neibart SS, Truty MJ, Jabbour SK, Hallemeier CL. Patterns of recurrence after primary local therapy for pancreatic ductal adenocarcinoma: A critical review of rationale and target delineation for (neo)adjuvant radiation therapy. Pract Radiat Oncol. doi:10.1016/j.prro.2022.06.004, Accessed May 6, 2022. Miller, 2022, Pancreatic stereotactic body radiation therapy with or without hypofractionated elective nodal irradiation, Int J Radiat Oncol Biol Phys, 112, 131, 10.1016/j.ijrobp.2021.07.1698 Cai, 2018, A practical implementation of physics quality assurance for photon adaptive radiotherapy, Z Med Phys, 28, 211, 10.1016/j.zemedi.2018.02.002 Lamb, 2017, Online adaptive radiation therapy: Implementation of a new process of care, Cureus, 9, e1618 Applied Radiation Oncology. FDA clears MRIdian A3i radiation therapy features announced at ASTRO. Available at. June 24, 2022. https://www.appliedradiationoncology.com/articles/fda-clears-mridian-a3i-radiation-therapy-features-announced-at-astro Accessed October 11, 2022. Tomaszewski, 2021, Heterogeneity analysis of MRI T2 maps for measurement of early tumor response to radiotherapy, NMR Biomed, 34, e4454, 10.1002/nbm.4454