A New Method with General Diagnostic Utility for the Calculation of Immunoglobulin G Avidity

American Society for Microbiology - Tập 6 Số 5 - Trang 725-728 - 1999
Maria H. Korhonen1, John Brunstein1, Heikki Haario2,3, Alexei Katnikov3, R Rescaldani4, Klaus Hedman1
1Haartman Institute, Department of Virology,1 and
2Department of Mathematics,2 University of Helsinki, and
3ProfMath Ltd.,3 Helsinki, Finland, and
4Ospedale S. Gerardo Di Monza, Monza, Italy4

Tóm tắt

ABSTRACT The reference method for immunoglobulin G (IgG) avidity determination includes reagent-consuming serum titration. Aiming at better IgG avidity diagnostics, we applied a logistic model for the reproduction of antibody titration curves. This method was tested with well-characterized serum panels for cytomegalovirus, Epstein-Barr virus, rubella virus, parvovirus B19, and Toxoplasma gondii . This approach for IgG avidity calculation is generally applicable and attains the diagnostic performance of the reference method while being less laborious and twice as cost-effective.

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Tài liệu tham khảo

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American Society for Microbiology

Tập 6 Số 5

725-728

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