A New Benzodiazepine Pharmacology

Journal of Pharmacology and Experimental Therapeutics - Tập 300 Số 1 - Trang 2-8 - 2002
Jean‐Marc Fritschy1, Udo Rudolph
1Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland. [email protected]

Tóm tắt

Từ khóa


Tài liệu tham khảo

Araujo, 1999, Native γ-aminobutyric acid type A receptors from rat hippocampus, containing both α1 and α5 subunits exhibit a single benzodiazepine binding site with α5 pharmacological properties., J Pharmacol Exp Ther, 290, 989

10.1074/jbc.271.44.27902

Barnard, 1998, Subtypes of γ-aminobutyric acidA receptors: classification on the bases of subunit structure and receptor function., Pharmacol Rev, 50, 291

10.1016/S0014-5793(98)00803-5

Bohlhalter, 1996, Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical study., J Neurosci, 16, 283, 10.1523/JNEUROSCI.16-01-00283.1996

10.1016/S0165-6147(99)01413-3

10.1113/jphysiol.1996.sp021806

10.1038/35051086

10.1124/mol.59.3.442

10.1038/sj.bjp.0703717

10.1038/80553

Dämgen, 1999, Zaleplon displays a selectivity to recombinant GABAA receptors different from zolpidem, zopiclone and benzodiazepines., Neurosci Res Comm, 25, 139, 10.1002/(SICI)1520-6769(199911/12)25:3<139::AID-NRC3>3.0.CO;2-W

Devor, 2001, Synaptic and extrasynaptic GABAA receptors in the inferior olivary nucleus differ in their spatial distribution, desensitization kinetics and subunit composition., J Neurophysiol, 85, 1686, 10.1152/jn.2001.85.4.1686

10.1038/2798

10.1016/S0304-3940(98)00397-8

10.1002/cne.903590111

10.1002/(SICI)1096-9861(19980112)390:2<194::AID-CNE3>3.0.CO;2-X

10.1002/(SICI)1096-9861(19980601)395:2<231::AID-CNE7>3.0.CO;2-3

Griebel, 2001, SL651498: an anxioselective compound with functional selectivity for α2- and α3-containing γ-aminobutyric acidA (GABAA) receptors., J Pharmacol Exp Ther, 298, 753

Haefely W (1994) Allosteric modulation of the GABAA-receptor channel: a mechanism for interaction with a multitude of central nervous system functions. in The Challenge of Neuropharmacology, eds Möhler H DaPrada M (Editiones Roche, Basel, Switzerland), pp 15–39.

10.1046/j.1460-9568.2000.00964.x

10.2165/00023210-200013060-00004

Jechlinger, 1998, Subunit composition and quantitative importance of heterooligomeric GABAA receptors containing α6 subunits., J Neurosci, 18, 2449, 10.1523/JNEUROSCI.18-07-02449.1998

10.1046/j.1460-9568.1998.00005.x

Khan, 1996, The α1 and α6 subunits can coexist in the same cerebellar GABAA receptor maintaining their individual benzodiazepine binding specificities., J Neurochem, 66, 685, 10.1046/j.1471-4159.1996.66020685.x

Kneussel, 1999, Loss of postsynaptic GABAA receptor clustering in gephyrin-deficient mice., J Neurosci, 19, 9287, 10.1523/JNEUROSCI.19-21-09289.1999

10.1016/0924-977X(92)90081-I

10.1126/science.290.5489.131

10.1038/75761

10.1016/0166-2236(94)90155-4

Mody, 2000, Differential activation of synaptic and extrasynaptic GABAA receptors., Eur J Neurosci, 11 (Suppl 12), 398

Möhler H (2001) Pharmacology and pathophysiology of GABAA receptor subtypes. in Pharmacology of GABA and Glycine Neurotransmission, ed Möhler H (Springer Verlag, New York), pp 101–116.

Möhler H Benke D Fritschy JM Benson J (2000) The benzodiazepine site of GABAA receptors. in GABA in the Nervous System: The View at Fifty Years, eds Martin DL Olsen RW (Lippincott Williams & Wilkins, Philadelphia), pp 97–112.

10.1038/35067500

10.1046/j.1460-9568.1999.00581.x

10.1016/S0896-6273(00)80382-7

Nusser, 1995, Relative densities of synaptic and extrasynaptic GABAA receptors on cerebellar granule cells as determined by a quantitative immunogold method., J Neurosci, 15, 2948, 10.1523/JNEUROSCI.15-04-02948.1995

10.1073/pnas.93.21.11939

Nusser, 1998, Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells., J Neurosci, 18, 1693, 10.1523/JNEUROSCI.18-05-01693.1998

Nusser, 1996, The α6 subunit of the GABAA receptor is concentrated in both inhibitory and excitatory synapses on cerebellar granule cells., J Neurosci, 16, 103, 10.1523/JNEUROSCI.16-01-00103.1996

10.1046/j.1460-9568.2001.01407.x

Olsen RW Homanics GE (2000) Functions of GABAA receptors: insights from mutant and knock out mice. in GABA in the Nervous System: The View at Fifty Years. eds Martin DL Olsen RW (Lippincott Williams & Wilkins, Philadelphia), pp 81–96.

Perrais, 1999, Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses., J Neurosci, 19, 578, 10.1523/JNEUROSCI.19-02-00578.1999

10.1016/S0306-4522(00)00442-5

10.1074/jbc.270.36.21285

10.1016/S0028-3908(96)00055-X

10.1038/44579

10.1016/S0165-6147(00)01646-1

10.1016/0014-2999(96)00510-9

10.1002/cne.903570102

10.1002/(SICI)1096-9861(20000515)420:4<481::AID-CNE6>3.0.CO;2-5

Scatton, 2000, Selectivity for GABAA receptor α subunits as a strategy for developing hypnoselective and anxioselective drugs., Int J Neuropsychopharmacol, 3, S41.3

Somogyi P (1989) Synaptic organization of GABAergic neurons and GABAA receptors in the lateral geniculate nucleus and visual cortex. in Neural Mechanisms of Visual Perception, eds Lam DKT Gilbert CD (Portfolio Publishing Co. Houston), pp 35–62.

10.1016/S0028-3908(96)00086-X

10.1124/mol.54.5.928

10.1038/81800

Whiting P Wafford KA McKernan RM (2000) Pharmacologic subtypes of GABAA receptors based on subunit composition. in GABA in the Nervous System: The View at Fifty Years, eds Martin DL Olsen RW (Lippincott Williams & Wilkins, Philadelphia), pp 113–126.

Wieland, 1992, A single histidine in GABAA receptors is essential for benzodiazepine agonist binding., J Biol Chem, 267, 1426, 10.1016/S0021-9258(18)45961-3