A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

American Association for the Advancement of Science (AAAS) - Tập 254 Số 5038 - Trang 1643-1647 - 1991
Pierre van der Bruggen1, Catia Traversari1, Patrick Chomez1, Christophe Lurquin1, Etienne De Plaen1, Benoı̂t Van den Eynde1, Alexander Knuth2, Thierry Boon1
1Ludwig Institute for Cancer Research, B-1200 Brussels, Belgium and Cellular Genetics Unit, Université Carholique de Louvain, Brussels, Belgium.
2I. Medizinische Klinik und Polilnik Johannes Gutenberg-Universität Mainz, D-6500 Mainz, Germany.

Tóm tắt

Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line. This gene shows no similarity to known sequences and belongs to a family of at least three genes. It is expressed by the original melanoma cells, other melanoma cell lines, and by some tumor cells of other histological types. No expression was observed in a panel of normal tissues. Antigen MZ2-E appears to be presented by HLA-A1; anti-MZ2-E CTLs of the original patient recognized two melanoma cell lines of other HLA-A1 patients that expressed the gene. Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample.

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American Association for the Advancement of Science (AAAS)

Tập 254 Số 5038

1643-1647

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