A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

New England Journal of Medicine - Tập 336 Số 17 - Trang 1216-1222 - 1997
Mary Sano1, Christopher Ernesto2, Ronald G. Thomas2,3, Melville R. Klauber2,3, Kimberly Schafer2, Michael Grundman2,4, Peter Woodbury2, John H. Growdon5, Carl W. Cotman6, Eric Pfeiffer7, Lon S. Schneider8, Leon J. Thal2,4
1Gertrude H. Sergievsky Center, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, University of California at San Diego, La Jolla
2Alzheimer's Disease Cooperative Study, University of California at San Diego, La Jolla
3Departments of Family and Preventive Medicine, University of California at San Diego, La Jolla
4Neurosciences, University of California at San Diego, La Jolla
5Department of Neurology, Harvard Medical School, Boston
6University of California at Irvine, Irvine
7University of South Florida, Tampa
8University of Southern California, Los Angeles

Tóm tắt

Từ khóa


Tài liệu tham khảo

Braak H, Braak E. Pathology of Alzheimer's disease. In: Calne DB, ed. Neurodegenerative diseases. Philadelphia: W.B. Saunders, 1994:585-613.

Davies P. An update on the neurochemistry of Alzheimer disease. In: Mayeux R, Rosen WG, eds. The dementias. Vol. 38 of Advances in neurology. New York: Raven Press, 1983:75-86.

Harman D. The free radical theory of aging. In: Pryor WA, ed. Free radicals in biology. Vol. 5. New York: Academic Press, 1982:255-75.

Porta EA. Role of oxidative damage in the aging process. In: Chow CK, ed. Cellular antioxidant defense mechanisms. Vol. 3. Boca Raton, Fla.: CRC Press, 1988:1-52.

10.1073/pnas.88.23.10540

10.1038/382120b0

10.1111/j.1600-0404.1983.tb01517.x

10.1056/NEJM199301213280305

10.1097/00002826-199004000-00004

10.1159/000116655

Burke WJ, 1993, J Am Geriatr Soc, 41, 1219, 10.1111/j.1532-5415.1993.tb07306.x

10.1016/0166-2236(85)90010-4

10.1016/0006-8993(90)91386-U

10.1089/neu.1988.5.61

10.1111/j.1471-4159.1985.tb08800.x

10.1016/0006-291X(92)90837-B

Morris JC, 1993, Neurology, 43, 2412, 10.1212/WNL.43.11.2412-a

10.1097/00002093-199601030-00004

10.1192/bjp.114.512.797

Rosen WG, 1984, Am J Psychiatry, 141, 1356, 10.1176/ajp.141.11.1356

10.1016/0022-3956(75)90026-6

Stern Y, 1994, J Gerontol A Biol Sci Med Sci, 49, M216, 10.1093/geronj/49.5.M216

Tariot PN, 1995, Am J Psychiatry, 152, 1349, 10.1176/ajp.152.9.1349

Richards M, 1991, Arch Neurol, 48, 1147, 10.1001/archneur.1991.00530230055021

10.2307/2531341

Holm S, 1979, Scand J Stat, 6, 65

10.1016/S0197-2456(84)80014-8

10.1001/jama.268.18.2523

10.1001/jama.271.13.985

Thal LJ, 1996, Neurology, 47, 705, 10.1212/WNL.47.3.705

Peyser CE, 1995, Am J Psychiatry, 152, 1771, 10.1176/ajp.152.12.1771

10.1080/10408399509527684

Meydani SN, 1995, Am J Clin Nutr, 62, 1462s, 10.1093/ajcn/62.6.1462S

Flagg EW, 1995, J Am Coll Nutr, 14, 419, 10.1080/07315724.1995.10718532