A Comparison of Vitamin A and Leucovorin for the Prevention of Methotrexate-Induced Micronuclei Production in Rat Bone Marrow

Kasahar, 1992, Mechanism of induction of micronuclei and chromosome aberration of micronuclei and chromosome aberrations in mouse bone marrow by multiple treatments of methotrexate, Mutat Res, 280, 117, 10.1016/0165-1218(92)90007-M Clark, 1999, Combination treatment with methotrexate and cyclosporine for severe Recalcitrant psoriasis, Br J Dermatol, 141, 279, 10.1046/j.1365-2133.1999.02976.x Hoffmeister, 1983, Methotrexate therapy in rheumatoid arthritis: 15 years experience, Am J Med, 75, 69, 10.1016/0002-9343(83)90477-1 Tulandi, 1991, Treatment of ectopic pregnancy by transvaginal intratubal methotrexate administration, Obstet Gynecol, 77, 627 Brown, 1991, Serial endovaginal sonography of ectopic pregnancies treated with methotrexate, Obset Gynecol, 77, 406 Li, 1984, Accumulations of DNA strand break and methotrexate cytotoxicity, Proc Natl cad Sci USA, 81, 5694, 10.1073/pnas.81.18.5694 Rodriguez Murcia, 1972, Cytological aberrations produced by methotrexate in mouse ascities tumours, Mut Res, 14, 405, 10.1016/0027-5107(72)90138-8 Hittelman, 1973, The type and time of occurrence of aminopterine-induced chromosome aberrations in cultured potorous cells, Mut Res, 18, 93, 10.1016/0027-5107(73)90024-9 Jensen, 1979, Cytogenetic effects of methotrexate on human cells in vivo, Mut Res, 64, 339, 10.1016/0165-1161(79)90126-2 1990, Single versus multiple dosing in the micronucleus test: the summary of the fourth collaborative study by CSGMT/JEMS-MMS, Mut Res, 234, 205, 10.1016/0165-1161(90)90017-I Slamenova, 2002, Effect of dietary intake of Vitamin A or E on the level of DNA damage, chromosomal aberrations and micronuclei induced in freshly isolated rat hepatocytes by different carcinogens, Nutr Cancer, 42, 117, 10.1207/S15327914NC421_16 Stich, 1984, Use of the micronucleus test to monitor the effect of vitamin A, beta-carotene and canthaxanthin on the buccal mucosa of betel/tobacco chewers, Int J Cancer, 15, 745, 10.1002/ijc.2910340602 Madhyastha, 2007, Protective effect of vitamin A on methotrexate induced micronuclei, Iranian Journal of Pharmacology & Therapeutics, 6, 1 Schmid, 1976, The micronucleus test for cytogenetic analysis, 31 Narayan, 2002, The genotoxic and cytotoxic effects of ribavirin in rat bone marrow, Mutat Res, 521, 179, 10.1016/S1383-5718(02)00239-5 Pearce, 1996, Erosion of psoriatic plaques: an early sign of methotrexate toxicity, J Am Acad Dermatol, 35, 835, 10.1016/S0190-9622(96)90097-3 Alarcon GS. In: Koopman Methotrexate: its use for the treatment of rheumatoid arthritis disorders. Arthritis and Allied Conditions Textbook of Rheumatology. 13th ed. Balitmore: Williams and Wilkins, 679-707 Baughman, 1998, Methotrexate for sarcoidosis, Sarcoidosis Vasc, Diffuse Lung Dis, 15, 147 Boehm, 1998, Management of cutaneous lupus erythematous with low dose methotrexate; indication for modulation for inflammatory mechanisms, Rheumatol Int, 18, 59, 10.1007/s002960050058 Hirohata, 1998, Low-dose weekly methotrexate for progressive neuropsychiatric manifestations in Behcet’s disease, J Neurol Sci, 159, 181, 10.1016/S0022-510X(98)00165-8 Levine, 1998, Inflammatory myopathy with cytochrome oxidase negative muscle fibres: methotrexate treatment, Muscle Nerve, 21, 1724, 10.1002/(SICI)1097-4598(199812)21:12<1724::AID-MUS15>3.0.CO;2-2 Dev, 1999, Methotrexate treatment for sarcoid-associated panuveitis, Ophthalmology, 106, 111, 10.1016/S0161-6420(99)90011-8 Sanoval, 1995, Adverse events in methotrexate-treated rheumatoid arthritis patients, Br J Rheumatol, 34, 49, 10.1093/rheumatology/XXXIV.suppl_2.49 Norman, 1985, Screening human populations for chromosome aberrations, Mutat Res, 143, 155, 10.1016/S0165-7992(85)80027-0 Muller, 1994, 76 Sandberg, 1983, A Chromosomal hypothesis of oncogenesis, Cancer Genet Cytogenet, 8, 277, 10.1016/0165-4608(83)90070-5 Stich, 1990, Towards an automated micronucleus assay as an internal dosimeter for carcinogenic exposed human population groups, Recent Results Cancer Res, 120, 94, 10.1007/978-3-642-84068-5_7 Alaoui-Jamali, 1991, Protective effect of vitamin A against the genotoxicity of NNK, a nicotine-derived N-nitrosamine, Carcinogenesis, 12, 379, 10.1093/carcin/12.3.379 Stich, 1984, Reduction with vitamin A and beta-carotene administration of proportion of micronucleated buccal mucosal cells in Asian betel nut and tobacco chewers, Lancet, 2, 1204, 10.1016/S0140-6736(84)91692-1 Stich, 1991, Remission of precancerous lesions in the oral cavity of tobacco chewers and maintenance of the protective effect of beta-carotene or vitamin A, Am J Clin Nutr, 53, 298S, 10.1093/ajcn/53.1.298S Toma, 1995, Effectiveness of beta carotene in cancer chemoprevention, Eur J Cancer Prev, 4, 213, 10.1097/00008469-199506000-00002 Shahin, 2001, Protective effect of folinic acid on low-dose methotrexate genotoxicity, Z Rheumatol, 60, 63, 10.1007/s003930170075 Keshava, 1998, Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells, Mut Res, 397, 221, 10.1016/S0027-5107(97)00216-9