A 12-week double-blind randomized clinical trial of vitamin D3supplementation on body fat mass in healthy overweight and obese women

Nutrition Journal - 2012
Amin Salehpour1, Farhad Hosseinpanah2, Farzad Shidfar1, Mohammadreza Vafa1, Maryam Razaghi1, Sahar Dehghani1, Anahita Hoshiarrad3, Mahmoodreza Gohari4
1Department of Nutrition, School of Public Health, Tehran University of Medical Sciences, Number 52, Alvand Street Arjantin Square, Tehran, Iran
2Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Floor 4th, Number 24, Parvaneh Street, Yemen Street, Chamran Exp, Tehran, Iran
3National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Number 42, Arghavan Street, Farahzadi Boulevard, Shahrak-e Gharb, Iran
4Department of Biostatistics, Tehran University of Medical Sciences, Number 52, Alvand Street, Arjantin Square, Tehran, Iran

Tóm tắt

Abstract Background Vitamin D concentrations are linked to body composition indices, particularly body fat mass. Relationships between hypovitaminosis D and obesity, described by both BMI and waist circumference, have been mentioned. We have investigated the effect of a 12-week vitamin D3 supplementation on anthropometric indices in healthy overweight and obese women. Methods In a double-blind, randomized, placebo-controlled, parallel-group trial, seventy-seven participants (age 38±8.1 years, BMI 29.8±4.1 kg/m2) were randomly allocated into two groups: vitamin D (25 μg per day as cholecalciferol) and placebo (25 μg per day as lactose) for 12 weeks. Body weight, height, waist, hip, fat mass, 25(OH) D, iPTH, and dietary intakes were measured before and after the intervention. Results Serum 25(OH)D significantly increased in the vitamin D group compared to the placebo group (38.2±32.7 nmol/L vs. 4.6±14.8 nmol/L; P<0.001) and serum iPTH concentrations were decreased by vitamin D3 supplementation (-0.26±0.57 pmol/L vs. 0.27±0.56 pmol/L; P<0.001). Supplementation with vitamin D3 caused a statistically significant decrease in body fat mass in the vitamin D group compared to the placebo group (-2.7±2.1 kg vs. -0.47±2.1 kg; P<0.001). However, body weight and waist circumference did not change significantly in both groups. A significant reverse correlation between changes in serum 25(OH) D concentrations and body fat mass was observed (r = -0.319, P = 0.005). Conclusion Among healthy overweight and obese women, increasing 25(OH) D concentrations by vitamin D3 supplementation led to body fat mass reduction. This trial is registered at clinicaltrials.gov as NCT01344161.

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