TLR signaling

Seminars in Immunology - Tập 19 - Trang 24-32 - 2007
Taro Kawai1,2, Shizuo Akira1,2
1Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
2Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan

Tài liệu tham khảo

Akira, 2006, Pathogen recognition and innate immunity, Cell, 124, 783, 10.1016/j.cell.2006.02.015 Uematsu, 2006, Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells, Nat Immunol, 7, 868, 10.1038/ni1362 Akira, 2004, Toll-like receptor signalling, Nat Rev Immunol, 4, 499, 10.1038/nri1391 Carty, 2006, The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling, Nat Immunol, 7, 1074, 10.1038/ni1382 Chen, 2005, Ubiquitin signalling in the NF-kappaB pathway, Nat Cell Biol, 7, 758, 10.1038/ncb0805-758 Shaulian, 2002, AP-1 as a regulator of cell life and death, Nat Cell Biol, 4, 131, 10.1038/ncb0502-e131 Sato, 2005, Essential function for the kinase TAK1 in innate and adaptive immune responses, Nat Immunol, 6, 1087, 10.1038/ni1255 Yamamoto, 2006, Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling, Nat Immunol, 7, 962, 10.1038/ni1367 Huang, 2004, Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3, Nat Immunol, 5, 98, 10.1038/ni1014 Dumitru, 2000, TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway, Cell, 103, 1071, 10.1016/S0092-8674(00)00210-5 Papoutsopoulou, 2006, ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses, Nat Immunol, 7, 606, 10.1038/ni1334 Matsuzawa, 2005, ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity, Nat Immunol, 6, 587, 10.1038/ni1200 Kawai, 1999, Unresponsiveness of MyD88-deficient mice to endotoxin, Immunity, 11, 115, 10.1016/S1074-7613(00)80086-2 Kawai, 2001, Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes, J Immunol, 167, 5887, 10.4049/jimmunol.167.10.5887 Yamamoto, 2002, A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling, J Immunol, 169, 6668, 10.4049/jimmunol.169.12.6668 Oshiumi, 2003, TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction, Nat Immunol, 4, 161, 10.1038/ni886 Yamamoto, 2003, Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway, Science, 301, 640, 10.1126/science.1087262 Hoebe, 2003, Identification of Lps2 as a key transducer of MyD88-independent TIR signalling, Nature, 424, 743, 10.1038/nature01889 Sharma, 2003, Triggering the interferon antiviral response through an IKK-related pathway, Science, 300, 1148, 10.1126/science.1081315 Fitzgerald, 2003, IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway, Nat Immunol, 4, 491, 10.1038/ni921 McWhirter, 2004, IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts, Proc Natl Acad Sci USA, 101, 233, 10.1073/pnas.2237236100 Hemmi, 2004, The roles of two IkappaB Kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection, J Exp Med, 199, 1641, 10.1084/jem.20040520 Perry, 2004, Differential requirement for TANK-binding kinase-1 in type I interferon responses to Toll-like receptor activation and viral infection, J Exp Med, 199, 1651, 10.1084/jem.20040528 Sato, 2003, J Immunol, 171, 4304, 10.4049/jimmunol.171.8.4304 Meylan, 2004, RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappaB activation, Nat Immunol, 5, 503, 10.1038/ni1061 Cusson-Hermance, 2005, Rip1 mediates the Trif-dependent toll-like receptor 3 and 4-induced NF-kappa B activation but does not contribute to IRF-3 activation, J Biol Chem, 280, 36560, 10.1074/jbc.M506831200 Covert, 2005, Achieving stability of lipopolysaccharide-induced NF-kappaB activation, Science, 309, 1854, 10.1126/science.1112304 Werner, 2005, Stimulus specificity of gene expression programs determined by temporal control of IKK activity, Science, 309, 1857, 10.1126/science.1113319 Honda, 2006, IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors, Nat Rev Immunol, 6, 644, 10.1038/nri1900 Colonna, 2004, Plasmacytoid dendritic cells in immunity, Nat Immunol, 5, 1219, 10.1038/ni1141 Liu, 2005, IPC: professional Type 1 interferon-producing cells and plasmacytoid dendritic cell precursors, Annu Rev Immunol, 23, 275, 10.1146/annurev.immunol.23.021704.115633 Hoshino, 2002, Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation, Int Immunol, 14, 1225, 10.1093/intimm/dxf089 Hemmi, 2003, The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets, J Immunol, 170, 3059, 10.4049/jimmunol.170.6.3059 Kawai, 2004, Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6, Nat Immunol, 5, 1061, 10.1038/ni1118 Honda, 2004, Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signalling, Proc Natl Acad Sci USA, 101, 15416, 10.1073/pnas.0406933101 Uematsu, 2005, Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) plays an essential role for TLR7- and TLR9-mediated interferon-a_induction, J Exp Med, 201, 915, 10.1084/jem.20042372 Hoshino, 2006, IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9, Nature, 440, 949, 10.1038/nature04641 Meylan, 2006, Intracellular pattern recognition receptors in the host response, Nature, 442, 39, 10.1038/nature04946 Meylan, 2006, Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses, Mol Cell, 22, 561, 10.1016/j.molcel.2006.05.012 Hacker, 2006, Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6, Nature, 439, 204, 10.1038/nature04369 Oganesyan, 2006, Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response, Nature, 439, 208, 10.1038/nature04374 Huang, 2004, IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression, J Biol Chem, 279, 51697, 10.1074/jbc.M410369200 Shinohara, 2006, Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells, Nat Immunol, 7, 498, 10.1038/ni1327 Negishi, 2006, Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program, Proc Natl Acad Sci USA, 103, 15136, 10.1073/pnas.0607181103 Takaoka, 2005, Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors, Nature, 434, 243, 10.1038/nature03308 Graham, 2006, A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus, Nat Genet, 38, 550, 10.1038/ng1782 Tsujimura, 2004, Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells, J Immunol, 172, 6820, 10.4049/jimmunol.172.11.6820 Barton, 2006, Intracellular localization of Toll-like receptor 9 prevents recognition of self-DNA but facilitates access to viral DNA, Nat Immunol, 7, 49, 10.1038/ni1280 Honda, 2005, Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction, Nature, 434, 1035, 10.1038/nature03547 Tabeta, 2006, The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9, Nat Immunol, 7, 156, 10.1038/ni1297 Rowe, 2006, The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Proc Natl Acad Sci USA, 103, 6299, 10.1073/pnas.0510041103 McGettrick, 2006, Trif-related adapter molecule is phosphorylated by PKC {epsilon} during Toll-like receptor 4 signaling, Proc Natl Acad Sci USA, 103, 9196, 10.1073/pnas.0600462103 Kagan, 2006, Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling, Cell, 125, 943, 10.1016/j.cell.2006.03.047 Miyake, 1995, RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family, J Immunol, 154, 3333, 10.4049/jimmunol.154.7.3333 Miyake, 1998, Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression, J Immunol, 161, 1348, 10.4049/jimmunol.161.3.1348 Divanovic, 2005, Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105, Nat Immunol, 6, 571, 10.1038/ni1198 Brint, 2004, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, Nat Immunol, 5, 373, 10.1038/ni1050 Wald, 2003, SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling, Nat Immunol, 4, 920, 10.1038/ni968 Chuang, 2004, Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors, Nat Immunol, 5, 495, 10.1038/ni1066 Kobayashi, 2002, IRAK-M is a negative regulator of Toll-like receptor signaling, Cell, 110, 191, 10.1016/S0092-8674(02)00827-9 Janssens, 2003, MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression, FEBS Lett, 548, 103, 10.1016/S0014-5793(03)00747-6 Hardy, 2004, The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory, J Biol Chem, 279, 27699, 10.1074/jbc.M403068200 Mansell, 2006, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation, Nat Immunol, 7, 148, 10.1038/ni1299 Su, 2006, TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling, Eur J Immunol, 36, 199, 10.1002/eji.200535415 Takeshita, 2005, TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF, Eur J Immunol, 35, 2477, 10.1002/eji.200526151 Wang, 2006, Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling, Nat Immunol, 7, 139, 10.1038/ni1294 Boone, 2004, The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses, Nat Immunol, 5, 1052, 10.1038/ni1110 Saitoh, 2006, Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1, Nat Immunol, 7, 598, 10.1038/ni1347 Gilchrist, 2006, Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4, Nature, 441, 173, 10.1038/nature04768 Negishi, 2005, Negative regulation of Toll-like-receptor signaling by IRF-4, Proc Natl Acad Sci USA, 102, 15989, 10.1073/pnas.0508327102 Martinon, 2006, Gout-associated uric acid crystals activate the NALP3 inflammasome, Nature, 440, 237, 10.1038/nature04516 Ishii, 2006, Innate immune recognition of, and regulation by, DNA, Trends Immunol, 27, 525, 10.1016/j.it.2006.09.002