Cellular and Molecular Mechanisms of Drug Dependence

American Association for the Advancement of Science (AAAS) - Tập 242 Số 4879 - Trang 715-723 - 1988
George F. Koob1, Floyd E. Bloom1
1Research Institute of Scripps Clinic, La Jolla, CA 92037.

Tóm tắt

The molecular and cellular actions of three classes of abused drugs—opiates, psychostimulants, and ethanol—are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.

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Tài liệu tham khảo

AMERICAN JOURNAL OF PSYCHIATRY 142 7: 9 (1985).

Drug Abuse and Drug Abuse Research 2nd Triennial Report to Congress (1987).

Sixth Special Report to Congress on Alcohol and Health (1987).

Diagnostic and Statistical Manual of Mental Disorders 3 166 (1987).

AGHAJANIAN, G.K., PERTUSSIS TOXIN BLOCKS THE OUTWARD CURRENTS EVOKED BY OPIATE AND ALPHA-2-AGONISTS IN LOCUS-COERULEUS NEURONS, BRAIN RESEARCH 371: 390 (1986).

AGHAJANIAN, G.K., TOLERANCE OF LOCUS COERULEUS NEURONS TO MORPHINE AND SUPPRESSION OF WITHDRAWAL RESPONSE BY CLONIDINE, NATURE 276: 186 (1978).

AMALRIC, M, LOW-DOSES OF METHYLNALOXONIUM IN THE NUCLEUS ACCUMBENS ANTAGONIZE HYPERACTIVITY INDUCED BY HEROIN IN THE RAT, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 23: 411 (1985).

AMIT, Z, ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 23: 65 (1977).

ANDRADE, R, MORPHINE-TOLERANCE AND DEPENDENCE IN THE LOCUS COERULEUS - SINGLE CELL STUDIES IN BRAIN-SLICES, EUROPEAN JOURNAL OF PHARMACOLOGY 91: 161 (1983).

ASTONJONES, G, ACTIVITY OF NOREPINEPHRINE-CONTAINING LOCUS COERULEUS NEURONS IN BEHAVING RATS ANTICIPATES FLUCTUATIONS IN THE SLEEP-WAKING CYCLE, JOURNAL OF NEUROSCIENCE 1: 876 (1981).

ASTONJONES, G, NOREPINEPHRINE-CONTAINING LOCUS COERULEUS NEURONS IN BEHAVING RATS EXHIBIT PRONOUNCED RESPONSES TO NON-NOXIOUS ENVIRONMENTAL STIMULI, JOURNAL OF NEUROSCIENCE 1: 887 (1981).

ASTONJONES, G, LOW-DOSES OF ETHANOL DISRUPT SENSORY RESPONSES OF BRAIN NORADRENERGIC NEURONS, NATURE 296: 857 (1982).

10.1126/science.3775363

BAXTER, L. R., JOURNAL OF CLINICAL PSYCHIATRY 49: 23 (1988).

BERGSTROM, L, ENKEPHALIN LEVELS DECREASE IN RAT STRIATUM DURING MORPHINE ABSTINENCE, EUROPEAN JOURNAL OF PHARMACOLOGY 60: 349 (1979).

BIRD, S.J., IONTOPHORETIC APPLICATION OF OPIATES TO LOCUS COERULEUS, BRAIN RESEARCH 122: 523 (1977).

Bjorklund, A., Handbook of Chemical Neuroanatomy 2: 55 (1984).

BLOIS, M.S., MEDICINE AND THE NATURE OF VERTICAL REASONING, NEW ENGLAND JOURNAL OF MEDICINE 318: 847 (1988).

Bloom F. Beta-Carbolines abd Tetrahydroisoquinolines (1982).

BLOOM, F.E., THE ENDORPHINS - A GROWING FAMILY OF PHARMACOLOGICALLY PERTINENT PEPTIDES, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 23: 151 (1983).

Bloom, F. E., Catecholamines, Neuropharmacology, and Central Nervous System: 159 (1984).

BLOOM, F.E., NEUROTRANSMITTERS - PAST, PRESENT, AND FUTURE-DIRECTIONS, FASEB JOURNAL 2: 32 (1988).

Bloom F. E. Goodman and Gilman's The Pharmacological Basis of Therapeutics 7 236 (1985).

BOZARTH, M.A., TOXICITY ASSOCIATED WITH LONG-TERM INTRAVENOUS HEROIN AND COCAINE SELF-ADMINISTRATION IN THE RAT, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 254: 81 (1985).

10.1126/science.6324347

BRADBURY, A.F., C FRAGMENT OF LIPOTROPIN HAS A HIGH AFFINITY FOR BRAIN OPIATE RECEPTORS, NATURE 260: 793 (1976).

BRITT, M.D., VENTRAL TEGMENTAL SITE OF OPIATE REWARD - ANTAGONISM BY A HYDROPHILIC OPIATE RECEPTOR BLOCKER, BRAIN RESEARCH 258: 105 (1983).

BRITTON, K.T., REGUL PEPT 16: 315 (1987).

BROWN, M.A., J STUD ALCOHOL 49: 412 (1988).

CALVINO, B, MORPHINE WITHDRAWAL SYNDROME - DIFFERENTIAL PARTICIPATION OF STRUCTURES LOCATED WITHIN THE AMYGDALOID COMPLEX AND STRIATUM OF THE RAT, BRAIN RESEARCH 177: 19 (1979).

CHEN, C.S., ACQUISITION OF BEHAVIORAL TOLERANCE TO ETHANOL AS A FUNCTION OF REINFORCED PRACTICE IN RATS, PSYCHOPHARMACOLOGY 63: 285 (1979).

CHILDERS, S.R., ENKEPHALIN - RADIOIMMUNOASSAY AND RADIORECEPTOR ASSAY IN MORPHINE-DEPENDENT RATS, EUROPEAN JOURNAL OF PHARMACOLOGY 46: 289 (1977).

CHRISTIE, M.J., CELLULAR MECHANISMS OF OPIOID TOLERANCE - STUDIES IN SINGLE BRAIN NEURONS, MOLECULAR PHARMACOLOGY 32: 633 (1987).

CLONINGER, C.R., MULTIFACTORIAL INHERITANCE WITH CULTURAL TRANSMISSION AND ASSORTATIVE MATING .3. FAMILY-STRUCTURE AND THE ANALYSIS OF SEPARATION EXPERIMENTS, AMERICAN JOURNAL OF HUMAN GENETICS 31: 366 (1979).

10.1126/science.2882604

CLOUET, D.H., MECHANISMS OF TOLERANCE TO AND DEPENDENCE ON NARCOTIC ANALGESIC DRUGS, ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 15: 49 (1975).

COLLIER, HOJ, CELLULAR SITE OF OPIATE DEPENDENCE, NATURE 283: 625 (1980).

COLLINS, R.J., PREDICTION OF ABUSE LIABILITY OF DRUGS USING IV-SELF-ADMINISTRATION BY RATS, PSYCHOPHARMACOLOGY 82: 6 (1984).

COSTA, E, ENDOGENOUS LIGANDS FOR BENZODIAZEPINE RECOGNITION SITES, BIOCHEMICAL PHARMACOLOGY 34: 3399 (1985).

DACKIS, C.A., BROMOCRIPTINE AS TREATMENT OF COCAINE ABUSE, LANCET 1: 1151 (1985).

10.1126/science.167.3920.1005

DEITRICH, R. A., ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 8: 487 (1984).

DEMINIERE, J.M., 6-HYDROXYDOPAMINE LESION OF THE DOPAMINE MESOCORTICOLIMBIC CELL-BODIES INCREASES (+)-AMPHETAMINE SELF-ADMINISTRATION, PSYCHOPHARMACOLOGY 83: 281 (1984).

DEMINIERE, J.M., INCREASED SENSITIVITY TO AMPHETAMINE AND FACILITATION OF AMPHETAMINE SELF-ADMINISTRATION AFTER 6-HYDROXYDOPAMINE LESIONS OF THE AMYGDALA, PSYCHOPHARMACOLOGY 94: 232 (1988).

DENEAU, G.A., SELF-ADMINISTRATION OF PSYCHOACTIVE SUBSTANCES BY MONKEY - A MEASURE OF PSYCHOLOGICAL DEPENDENCE, PSYCHOPHARMACOLOGIA 16: 30 (1969).

DEUTSCH, J.A., IMPORTANCE OF POST-INGESTIONAL FACTORS IN LIMITING ALCOHOL CONSUMPTION IN RAT, BEHAVIORAL BIOLOGY 22: 128 (1978).

DOLE, V. P., ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 10: 361 (1986).

Sixth Special Report to Congress on Alcohol and Health (1987).

DUGGAN, A. W., PHARMACOLOGICAL REVIEWS 35: 219 (1982).

EDDY, N.B., BULLETIN OF THE WORLD HEALTH ORGANIZATION 32: 723 (1965).

EHLERS, C.L., CHRONIC ETHANOL EXPOSURE POTENTIATES THE LOCOMOTOR-ACTIVATING EFFECTS OF CORTICOTROPIN-RELEASING FACTOR (CRF) IN RATS, REGULATORY PEPTIDES 19: 345 (1987).

EINHORN, L.C., ELECTROPHYSIOLOGICAL EFFECTS OF COCAINE IN THE MESOACCUMBENS DOPAMINE SYSTEM - STUDIES IN THE VENTRAL TEGMENTAL AREA, JOURNAL OF NEUROSCIENCE 8: 100 (1988).

10.1126/science.159.3816.739

FOOTE, S.L., NUCLEUS LOCUS CERULEUS - NEW EVIDENCE OF ANATOMICAL AND PHYSIOLOGICAL SPECIFICITY, PHYSIOLOGICAL REVIEWS 63: 844 (1983).

FREDERICKSON, RCA, LIFE SCI 24: 541 (1975).

FRENCH, E.D., THE EXCITATORY RESPONSE OF INVITRO HIPPOCAMPAL PYRAMIDAL CELLS TO NORMORPHINE AND METHIONINE-ENKEPHALIN MAY BE MEDIATED BY DIFFERENT RECEPTOR POPULATIONS, EXPERIMENTAL BRAIN RESEARCH 48: 238 (1982).

FRENCH, E.D., AN IONTOPHORETIC SURVEY OF OPIOID PEPTIDE ACTIONS IN THE RAT LIMBIC SYSTEM - IN SEARCH OF OPIATE EPILEPTOGENIC MECHANISMS, REGULATORY PEPTIDES 1: 127 (1980).

FRY, J.P., SPECIFIC VERSUS NONSPECIFIC ACTIONS OF OPIOIDS ON HIPPOCAMPAL NEURONS IN THE RAT-BRAIN, BRAIN RESEARCH 163: 295 (1979).

FRY, J.P., DEMONSTRATION OF NALOXONE-PRECIPITATED OPIATE WITHDRAWAL ON SINGLE NEURONS IN THE MORPHINE-TOLERANT-DEPENDENT RAT-BRAIN, BRITISH JOURNAL OF PHARMACOLOGY 68: 585 (1980).

GATTO, G.J., CHRONIC ETHANOL TOLERANCE THROUGH FREE-CHOICE DRINKING IN THE P-LINE OF ALCOHOL-PREFERRING RATS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 28: 111 (1987).

GAWIN, F, PHARMACOLOGICAL TREATMENTS OF COCAINE ABUSE, PSYCHIATRIC CLINICS OF NORTH AMERICA 9: 573 (1986).

GAWIN, F.H., ABSTINENCE SYMPTOMATOLOGY AND PSYCHIATRIC-DIAGNOSIS IN COCAINE ABUSERS - CLINICAL OBSERVATIONS, ARCHIVES OF GENERAL PSYCHIATRY 43: 107 (1986).

GESSA, G.L., LOW-DOSES OF ETHANOL ACTIVATE DOPAMINERGIC-NEURONS IN THE VENTRAL TEGMENTAL AREA, BRAIN RESEARCH 348: 201 (1985).

GLASS, J, DIRECT ANALYSIS OF THE RELEASE OF METHIONINE-ENKEPHALIN FROM GUINEA-PIG MYENTERIC PLEXUS - MODULATION BY ENDOGENOUS OPIOIDS AND EXOGENOUS MORPHINE, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 239: 742 (1986).

GLICKMAN, S.E., A BIOLOGICAL THEORY OF REINFORCEMENT, PSYCHOLOGICAL REVIEW 74: 81 (1967).

GOEDERS, N.E., SELF-ADMINISTRATION OF METHIONINE ENKEPHALIN INTO THE NUCLEUS ACCUMBENS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 20: 451 (1984).

10.1126/science.6879176

GOLD, L.H., THE ROLE OF MESOLIMBIC DOPAMINE IN CONDITIONED LOCOMOTION PRODUCED BY AMPHETAMINE, BEHAVIORAL NEUROSCIENCE 102: 544 (1988).

GOLDBERG, S.R., CONDITIONED NALORPHINE-INDUCED ABSTINENCE CHANGES - PERSISTENCE IN POST MORPHINE-DEPENDENT MONKEYS, JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR 14: 33 (1970).

10.1073/pnas.76.12.6666

GOLDSTEIN, A, RESEARCH PUBLICATIONS. ASSOCIATION FOR RESEARCH IN NERVOUS AND MENTAL DISEASE 46: 265 (1968).

GOLDSTEIN, D.B., ETHANOL-INDUCED ADAPTATION IN BIOLOGICAL-MEMBRANES, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 492: 103 (1987).

GOODWIN, D.W., IS ALCOHOLISM HEREDITARY - REVIEW AND CRITIQUE, ARCHIVES OF GENERAL PSYCHIATRY 25: 545 (1971).

GRAY, P.W., CLONING AND EXPRESSION OF CDNA FOR HUMAN DIAZEPAM BINDING INHIBITOR, A NATURAL LIGAND OF AN ALLOSTERIC REGULATORY SITE OF THE GAMMA-AMINOBUTYRIC-ACID TYPE-A RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 7547 (1986).

GRIFFITHS, R.R., ADV SUBSTANC ABUSE 1: 1 (1980).

Hand, T. H., Brain Research 474: 364 (1988).

HARDING, W.M., ADV SUBSTANC ABUSE 3: 27 (1983).

HENRIKSEN, S.J., NATL I DRUG ABUSE RE 84: 239 (1984).

HERZ, A, MORPHINE ABSTINENCE SYNDROME IN RABBITS PRECIPITATED BY INJECTION OF MORPHINE ANTAGONISTS INTO VENTRICULAR SYSTEM AND RESTRICTED PARTS OF, PSYCHOPHARMACOLOGIA 26: 219 (1972).

HILAKIVI, L, ALCOHOL 1: 71 (1984).

HIMMELSBACH, C.K., FEDERATION PROCEEDINGS 2: 201 (1943).

HUBNER, C.B., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 13: 1717 (1987).

HUGHES, J, IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY, NATURE 258: 577 (1975).

ISABELL, H, Q J STUD ALCOHOL 16: 1 (1955).

JAFFE, J.H., GOODMAN GILMANS PHAR: 532 (1985).

JAFFE, J.H., RESEARCH PUBLICATIONS. ASSOCIATION FOR RESEARCH IN NERVOUS AND MENTAL DISEASE 46: 226 (1968).

JOHNSON, S.M., DEPENDENCE IN THE ABSENCE OF TOLERANCE TO MORPHINE, EUROPEAN JOURNAL OF PHARMACOLOGY 97: 305 (1984).

Khachaturian, H., Handbook of Chemical Neuroanatomy 4: 216 (1985).

KOKKINIDIS, L, AMPHETAMINE WITHDRAWAL - A BEHAVIORAL-EVALUATION, LIFE SCIENCES 38: 1617 (1986).

KOKKINIDIS, L, POST-AMPHETAMINE DEPRESSION OF SELF-STIMULATION RESPONDING FROM THE SUBSTANTIA NIGRA - REVERSAL BY TRICYCLIC ANTI-DEPRESSANTS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 13: 379 (1980).

Koob, G. F., Alcohol 5: 437 (1988).

Koob G. F. Animal Models of Depression (1989).

Koob, G. F., Annals of the New York Academy of Sciences 537: 216 (1988).

KOOB, G.F., EFFECTS OF OPIATE ANTAGONISTS AND THEIR QUATERNARY DERIVATIVES ON HEROIN SELF-ADMINISTRATION IN THE RAT, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 229: 481 (1984).

KOOB, G.F., THE D1 DOPAMINE RECEPTOR ANTAGONIST SCH-23390 INCREASES COCAINE SELF-ADMINISTRATION IN THE RAT, NEUROSCIENCE LETTERS 79: 315 (1987).

KOOB, G.F., DESTRUCTION OF THE LOCUS COERULEUS OR THE DORSAL NE BUNDLE DOES NOT ALTER THE RELEASE OF PUNISHED RESPONDING BY ETHANOL AND CHLORDIAZEPOXIDE, PHYSIOLOGY & BEHAVIOR 33: 479 (1984).

KOOB, G.F., THE EFFECTS OF FG-7142 AND RO-15-1788 ON THE RELEASE OF PUNISHED RESPONDING PRODUCED BY CHLORDIAZEPOXIDE AND ETHANOL IN THE RAT, PSYCHOPHARMACOLOGY 90: 173 (1986).

KOOB, G.F., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 13: 918 (1987).

KOOB G.F. unpublished data.

KORNETSKY, C, REWARD AND DETECTION THRESHOLDS FOR BRAIN-STIMULATION - DISSOCIATIVE EFFECTS OF COCAINE, BRAIN RESEARCH 209: 496 (1981).

KORNETSKY, C, AN ANIMAL-MODEL FOR OPIATE INDUCED EUPHORIA AND ANALGESIA, THERAPEUTISCHE UMSCHAU 39: 617 (1982).

KOSTERLITZ, H.W., BIOSYNTHESIS OF MORPHINE IN THE ANIMAL KINGDOM, NATURE 330: 606 (1987).

KRITIKOS, P.G., UN B NARC 19: 187 (1967).

Kuhar, M. H., Nature 245:447 (1976).

LACEY, M.G., INT NARCOTICS RES C: 85 (1988).

LEBLANC, A.E., BEHAVIORAL AUGMENTATION OF TOLERANCE TO ETHANOL IN RAT, PSYCHOPHARMACOLOGIA 30: 117 (1973).

LEITH, N.J., AMPHETAMINE AND REWARD SYSTEM - EVIDENCE FOR TOLERANCE AND POST-DRUG DEPRESSION, PSYCHOPHARMACOLOGIA 46: 19 (1976).

LEITH, N.J., EFFECTS OF CHRONIC AMPHETAMINE OR RESERPINE ON SELF-STIMULATION RESPONDING - ANIMAL-MODEL OF DEPRESSION, PSYCHOPHARMACOLOGY 72: 9 (1980).

LESLIE, F.M., PHARMACOL REV 39: 198 (1987).

LI, T.K., NIDA RES MONOGR 66: 41 (1986).

LILJEQUIST, S, REVERSAL OF THE ANTI-CONFLICT ACTION OF VALPROATE BY VARIOUS GABA AND BENZODIAZEPINE ANTAGONISTS, LIFE SCIENCES 34: 2525 (1984).

LING, GSF, SEPARATION OF OPIOID ANALGESIA FROM RESPIRATORY DEPRESSION - EVIDENCE FOR DIFFERENT RECEPTOR MECHANISMS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 232: 149 (1985).

LYNESS, W.H., DESTRUCTION OF DOPAMINERGIC NERVE-TERMINALS IN NUCLEUS ACCUMBENS - EFFECT ON D-AMPHETAMINE SELF-ADMINISTRATION, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 11: 553 (1979).

MADAMBA, S, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 13: 501 (1987).

MANCILLAS, J.R., SOMATOSTATIN SELECTIVELY ENHANCES ACETYLCHOLINE-INDUCED EXCITATIONS IN RAT HIPPOCAMPUS AND CORTEX, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 7518 (1986).

10.1126/science.2867600

Markou A. Soc. Neurosci. Abstr. in press.

MARTIN, W.R., HDB EXPT PHARMACOLOG 45: 43 (1977).

MARTIN, W.R., PHARMACOL REV 35: 283 (1984).

MARTIN, W.R., PHARMACOL REV 35: 285 (1984).

MCCLEARN, G.E., DIFFERENCES IN ALCOHOL PREFERENCE AMONG INBRED STRAINS OF MICE, QUARTERLY JOURNAL OF STUDIES ON ALCOHOL 20: 691 (1959).

MCGINTY, J.F., DOUBLE IMMUNOSTAINING REVEALS DISTINCTIONS AMONG OPIOID PEPTIDERGIC NEURONS IN THE MEDIAL BASAL HYPOTHALAMUS, BRAIN RESEARCH 278: 145 (1983).

Merchenthaler, I., Handbook of Chemical Neuroanatomy 3: 273 (1985).

MEREU, G, ETHANOL STIMULATES THE FIRING RATE OF NIGRAL DOPAMINERGIC-NEURONS IN UNANESTHETIZED RATS, BRAIN RESEARCH 292: 63 (1984).

MEREU, G, LOW-DOSES OF ETHANOL INHIBIT THE FIRING OF NEURONS IN THE SUBSTANTIA-NIGRA, PARS RETICULATA - A GABAERGIC EFFECT, BRAIN RESEARCH 360: 325 (1985).

MINNEMAN, K.P., HIGH-EFFICIENCY COUPLING OF ALPHA-1 ADRENERGIC-RECEPTORS TO INOSITOL PHOSPHOLIPID-METABOLISM REVEALED BY DENERVATION OF RAT VAS-DEFERENS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 244: 226 (1988).

MIYATA, M, PROTRACTED TREATMENT WITH DIAZEPAM INCREASES THE TURNOVER OF PUTATIVE ENDOGENOUS LIGANDS FOR THE BENZODIAZEPINE BETA-CARBOLINE RECOGNITION SITE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 1444 (1987).

MOCCHETTI, I, INVIVO STUDIES OF THE REGULATION OF NEUROPEPTIDE STORES IN STRUCTURES OF THE RAT-BRAIN, NEUROPHARMACOLOGY 26: 855 (1987).

MOCHLYROSEN, D, CHRONIC ETHANOL CAUSES HETEROLOGOUS DESENSITIZATION OF RECEPTORS BY REDUCING ALPHA-S MESSENGER-RNA, NATURE 333: 848 (1988).

10.1126/science.2892268

MURPHY, J.M., ALCOHOL DRUG RES 7: 33 (1986).

MURPHY, J.M., CONTENTS OF MONOAMINES IN FOREBRAIN REGIONS OF ALCOHOL-PREFERRING (P) AND ALCOHOL-NONPREFERRING (NP) LINES OF RATS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 26: 389 (1987).

10.1126/science.160.3835.1469

NADEL, L, ESSAYS NERVOUS SYSTE: 367 (1974).

NAUTA, WJH, EFFERENT CONNECTIONS AND NIGRAL AFFERENTS OF NUCLEUS ACCUMBENS SEPTI IN RAT, NEUROSCIENCE 3: 385 (1978).

10.1126/science.7394531

NICOLL, R.A., NEURONAL ACTIONS OF ENDORPHINS AND ENKEPHALINS AMONG BRAIN-REGIONS - COMPARATIVE MICROIONTOPHORETIC STUDY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 74: 2584 (1977).

NORTH, R.A., ON THE POTASSIUM CONDUCTANCE INCREASED BY OPIOIDS IN RAT LOCUS COERULEUS NEURONS, JOURNAL OF PHYSIOLOGY-LONDON 364: 265 (1985).

NORTH, R.A., MU-RECEPTOR AND DELTA-RECEPTOR BELONG TO A FAMILY OF RECEPTORS THAT ARE COUPLED TO POTASSIUM CHANNELS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 5487 (1987).

NYLANDER, I, DOPAMINE-RECEPTORS MEDIATE ALTERATIONS IN STRIATONIGRAL DYNORPHIN AND SUBSTANCE-P PATHWAYS, NEUROPHARMACOLOGY 26: 1295 (1987).

OBRIEN, C.P., ANN NY ACAD SCI 398: 377 (1983).

OBRIEN, C.P., PHARMACOL REV 27: 533 (1976).

OLDS, M.E., SELF-ADMINISTRATION OF D-ALA2-MET-ENKEPHALINAMIDE AT HYPOTHALAMIC SELF-STIMULATION SITES, BRAIN RESEARCH 194: 155 (1980).

PALMER, M.R., CATECHOLAMINE MODULATION OF ENKEPHALIN-INDUCED ELECTRO-PHYSIOLOGICAL RESPONSES IN CEREBRAL-CORTEX, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 213: 205 (1980).

10.1038/331585a0

10.1007/BF00427441

PHILLIPSON, O.T., AFFERENT-PROJECTIONS TO THE VENTRAL TEGMENTAL AREA OF TSAI AND INTERFASCICULAR NUCLEUS - HORSERADISH-PEROXIDASE STUDY IN THE RAT, JOURNAL OF COMPARATIVE NEUROLOGY 187: 117 (1979).

PICKENS, R, HDB PSYCHOPHARMACOLO 12: 1 (1978).

PICKENS, R, CHEMICAL INTERACTIONS IN METHAMPHETAMINE REINFORCEMENT, PSYCHOLOGICAL REPORTS 23: 1267 (1968).

10.1126/science.3289116

Post R. M. Animal Models of Depression (1989).

POST, R.M., DRUG-ENVIRONMENT INTERACTION - CONTEXT DEPENDENCY OF COCAINE-INDUCED BEHAVIORAL SENSITIZATION, LIFE SCIENCES 28: 755 (1981).

POST, R.M., INCREASING EFFECTS OF REPETITIVE COCAINE ADMINISTRATION IN RAT, NATURE 260: 731 (1976).

REID, L.D., ALCOHOL 1: 33 (1984).

RILEY, E.P., SELECTIVE BREEDING OF RATS FOR DIFFERENCES IN REACTIVITY TO ALCOHOL - APPROACH TO AN ANIMAL-MODEL OF ALCOHOLISM .1. GENERAL PROCEDURES, JOURNAL OF STUDIES ON ALCOHOL 37: 1535 (1976).

10.1126/science.2820058

ROBERTS, DCS, DISRUPTION OF COCAINE SELF-ADMINISTRATION FOLLOWING 6-HYDROXYDOPAMINE LESIONS OF THE VENTRAL TEGMENTAL AREA IN RATS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 17: 901 (1982).

ROBERTS, DCS, ROLE OF ASCENDING CATECHOLAMINERGIC SYSTEMS IN INTRAVENOUS SELF-ADMINISTRATION OF COCAINE, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 6: 615 (1977).

10.1016/0091-3057(80)90166-5

ROGERS, J, PHYSIOLOGICAL CORRELATES OF ETHANOL INTOXICATION, TOLERANCE, AND DEPENDENCE IN RAT CEREBELLAR PURKINJE-CELLS, BRAIN RESEARCH 196: 183 (1980).

ROGERS, J, ETHANOL INCREASES SINGLE UNIT-ACTIVITY IN THE INFERIOR OLIVARY NUCLEUS, BRAIN RESEARCH 385: 253 (1986).

ROTH, J, NEW ENGLAND JOURNAL OF MEDICINE 306: 523 (1982).

ROUTTENBERG, A, INTRACRANIAL CHEMICAL INJECTION AND BEHAVIOR - CRITICAL REVIEW, BEHAVIORAL BIOLOGY 7: 601 (1972).

SAMSON, H.H., INITIATION OF ETHANOL REINFORCEMENT USING A SUCROSE-SUBSTITUTION PROCEDURE IN FOOD-SATED AND WATER-SATED RATS, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 10: 436 (1986).

SAMSON, H.H., NEUROBEHAVIORAL PHAR: 221 (1987).

SAMSON, H.H., ORAL ETHANOL REINFORCEMENT IN THE RAT - EFFECT OF THE PARTIAL INVERSE BENZODIAZEPINE AGONIST RO15-4513, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 27: 517 (1987).

SATOH, M, OPIATE AGONIST-ANTAGONIST INTERACTION AT CORTICAL-NEURONS OF NAIVE AND TOLERANT-DEPENDENT RATS, BRAIN RESEARCH 82: 378 (1974).

SATOH, M, ACTIONS OF OPIATES UPON SINGLE UNIT-ACTIVITY IN CORTEX OF NAIVE AND TOLERANT RATS, BRAIN RESEARCH 115: 99 (1976).

SCHUCKIT, M.A., SELF-RATING OF ALCOHOL-INTOXICATION BY YOUNG MEN WITH AND WITHOUT FAMILY HISTORIES OF ALCOHOLISM, JOURNAL OF STUDIES ON ALCOHOL 41: 242 (1980).

SCHUCKIT, M.A., BIOLOGICAL MARKERS IN ALCOHOLISM, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 10: 191 (1986).

SCHUSTER, C.R., SELF ADMINISTRATION OF AND BEHAVIORAL DEPENDENE ON DRUGS, ANNUAL REVIEW OF PHARMACOLOGY 9: 483 (1969).

SCHUSTER, C.R., BEHAVIORAL VARIABLES AFFECTING DEVELOPMENT OF AMPHETAMINE TOLERANCE, PSYCHOPHARMACOLOGIA 9: 170 (1966).

SCOTT J.M. WHITE POPPY HIST OPI (1969).

SHUSTER, L, NIDA RES MONOGR 54: 50 (1984).

SIEGEL, S, ATTENUATION OF ETHANOL TOLERANCE BY A NOVEL STIMULUS, PSYCHOPHARMACOLOGY 88: 258 (1986).

10.1126/science.935870

10.1126/science.200.4339.344

SIGGINS, G.R., ELECTROPHYSIOLOGY OF ETHANOL ON CENTRAL NEURONS, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 492: 350 (1987).

SIGGINS, G.R., EFFECTS OF ETHANOL ON CA-1 AND CA-3 PYRAMIDAL CELLS IN THE HIPPOCAMPAL SLICE PREPARATION - AN INTRACELLULAR STUDY, BRAIN RESEARCH 414: 22 (1987).

SIGGINS, G.R., MORPHINE AND OPIOID-PEPTIDES REDUCE INHIBITORY SYNAPTIC POTENTIALS IN HIPPOCAMPAL PYRAMIDAL CELLS-INVITRO WITHOUT ALTERATION OF MEMBRANE-POTENTIAL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78: 5235 (1981).

SIMANTOV, R, MORPHINE-LIKE PEPTIDES IN MAMMALIAN BRAIN - ISOLATION, STRUCTURE ELUCIDATION, AND INTERACTIONS WITH OPIATE RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 73: 2515 (1976).

SIMPSON, D.M., BEHAVIORAL WITHDRAWAL FOLLOWING SEVERAL PSYCHOACTIVE-DRUGS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 7: 59 (1977).

SINCLAIR, J.G., THE EFFECTS OF ETHANOL ON CEREBELLAR PURKINJE-CELL DISCHARGE PATTERN AND INHIBITION EVOKED BY LOCAL SURFACE STIMULATION, BRAIN RESEARCH 204: 465 (1981).

SINCLAIR, J.G., THE EFFECTS OF ETHANOL ON CEREBELLAR PURKINJE-CELLS IN NAIVE AND ALCOHOL-DEPENDENT RATS, CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 58: 429 (1980).

SNYDER S.H. DRUGS BRAIN (1986).

SOLOMON R.L. PSYCHOPATHOLOGY EXPT (1977).

SPARBER, S.B., CLONIDINE ANTAGONIZES NALOXONE-INDUCED SUPPRESSION OF CONDITIONED BEHAVIOR AND BODY-WEIGHT LOSS IN MORPHINE-DEPENDENT RATS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 9: 319 (1978).

SPORN, J.R., SUPERSENSITIVITY IN RAT CEREBRAL-CORTEX - PRE-SYNAPTIC AND POSTSYNAPTIC EFFECTS OF 6-HYDROXYDOPAMINE AT NORADRENERGIC SYNAPSES, MOLECULAR PHARMACOLOGY 13: 1170 (1977).

STEIN, L, SELF-STIMULATION OF BRAIN + CENTRAL STIMULANT ACTION OF AMPHETAMINE, FEDERATION PROCEEDINGS 23: 836 (1964).

SWERDLOW, N.R., THE NEURAL SUBSTRATES OF APOMORPHINE-STIMULATED LOCOMOTOR-ACTIVITY FOLLOWING DENERVATION OF THE NUCLEUS ACCUMBENS, LIFE SCIENCES 35: 2537 (1984).

TABAKOFF, B, TOLERANCE AND THE ETIOLOGY OF ALCOHOLISM - HYPOTHESIS AND MECHANISM, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 12: 184 (1988).

TABAKOFF, B, COMMENTARY ON ETHANOL TOLERANCE, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 6: 252 (1982).

TABAKOFF, B, ANIMAL MODELS ALCOHO: 271 (1980).

TABAKOFF, B, EFFECTS OF 6-HYDROXYDOPAMINE ON TOLERANCE TO AND DEPENDENCE ON ETHANOL, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 203: 319 (1977).

TARASCHI, T.F., MEMBRANE STRUCTURAL ALTERATIONS CAUSED BY CHRONIC ETHANOL-CONSUMPTION - THE MOLECULAR-BASIS OF MEMBRANE TOLERANCE, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 492: 171 (1987).

TICKU, M.K., ALTERATIONS IN GAMMA-AMINOBUTYRIC ACID RECEPTOR SENSITIVITY FOLLOWING ACUTE AND CHRONIC ETHANOL TREATMENTS, JOURNAL OF NEUROCHEMISTRY 34: 417 (1980).

TICKU, M.K., THE INTERACTIONS OF ETHANOL WITH THE BENZODIAZEPINE-GABA RECEPTOR-IONOPHORE COMPLEX, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 18: 15 (1983).

TRENDELENBURG, U, SUPERSENSITIVITY AND SUBSENSITIVITY TO SYMPATHOMIMETIC AMINES, PHARMACOLOGICAL REVIEWS 15: 225 (1963).

VACCARINO, F.J., EFFECTS OF OPIATE ANTAGONIST TREATMENT INTO EITHER THE PERIAQUEDUCTAL GRAY OR NUCLEUS-ACCUMBENS ON HEROIN-INDUCED LOCOMOTOR ACTIVATION, BRAIN RESEARCH BULLETIN 19: 545 (1987).

VACCARINO, F.J., EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATION OF METHYL NALOXONIUM CHLORIDE ON HEROIN SELF-ADMINISTRATION IN THE RAT, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 23: 495 (1985).

VACCARINO, F.J., BLOCKADE OF NUCLEUS ACCUMBENS OPIATE RECEPTORS ATTENUATES INTRAVENOUS HEROIN REWARD IN THE RAT, PSYCHOPHARMACOLOGY 86: 37 (1985).

WALAAS, I, BIOCHEMICAL-EVIDENCE FOR GAMMA-AMINOBUTYRATE CONTAINING FIBERS FROM THE NUCLEUS ACCUMBENS TO THE SUBSTANTIA NIGRA AND VENTRAL TEGMENTAL AREA IN THE RAT, NEUROSCIENCE 5: 63 (1980).

WALKER, J.M., OPPOSITE EFFECTS OF MU-OPIATES AND KAPPA-OPIATES ON THE FIRING-RATE OF DOPAMINE CELLS IN THE SUBSTANTIA-NIGRA OF THE RAT, EUROPEAN JOURNAL OF PHARMACOLOGY 134: 53 (1987).

WALMSLEY, J, PHARMACOL REV 35: 69 (1983).

WAY, E.L., ANN NY ACAD SCI 398: 12 (1983).

WEI, E, BRAIN SITES OF PRECIPITATED ABSTINENCE IN MORPHINE-DEPENDENT RATS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 185: 108 (1973).

10.1126/science.177.4049.616

WEITZ, C.J., SYNTHESIS OF THE SKELETON OF THE MORPHINE MOLECULE BY MAMMALIAN LIVER, NATURE 330: 674 (1987).

10.1126/science.7244656

WHITE, F.J., ELECTROPHYSIOLOGICAL EVIDENCE FOR THE EXISTENCE OF BOTH D-1 AND D-2 DOPAMINE-RECEPTORS IN THE RAT NUCLEUS-ACCUMBENS, JOURNAL OF NEUROSCIENCE 6: 274 (1986).

WHITE, F.J., NEUROPHARMACOLOGY DO: 67 (1987).

WIKLER, A, NARCOTICS: 85 (1965).

WILLIAMS, J.T., ENKEPHALIN OPENS POTASSIUM CHANNELS ON MAMMALIAN CENTRAL NEURONS, NATURE 299: 74 (1982).

WILLIAMS, L.T., THYROID-HORMONE REGULATION OF BETA-ADRENERGIC-RECEPTOR NUMBER, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 2787 (1977).

WILSON, JVR, BEHAV GENET 11: 291 (1984).

WISE, R.A., THE NEUROBIOLOGY OF CRAVING - IMPLICATIONS FOR THE UNDERSTANDING AND TREATMENT OF ADDICTION, JOURNAL OF ABNORMAL PSYCHOLOGY 97: 118 (1988).

WOLFE B.B. J PHARM EXP THER 207 (1978).

WOODS, J.H., RECENT ADV STUDIES A: 413 (1970).

WOOLVERTON, W.L., EFFECTS OF A D1 AND A D2 DOPAMINE ANTAGONIST ON THE SELF-ADMINISTRATION OF COCAINE AND PIRIBEDIL BY RHESUS-MONKEYS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 24: 531 (1986).

WUSTER, M, INQUIRY INTO ENDORPHINERGIC FEEDBACK MECHANISMS DURING THE DEVELOPMENT OF OPIATE TOLERANCE-DEPENDENCE, BRAIN RESEARCH 189: 403 (1980).

YOKEL, R.A., ATTENUATION OF INTRAVENOUS AMPHETAMINE REINFORCEMENT BY CENTRAL DOPAMINE BLOCKADE IN RATS, PSYCHOPHARMACOLOGY 48: 311 (1976).

10.1126/science.1114313

YOUNG, W.S., NEW METHOD FOR RECEPTOR AUTO-RADIOGRAPHY - [OPIOID-H-3 RECEPTORS IN RAT-BRAIN, BRAIN RESEARCH 179: 255 (1979).

ZHAO, Z.Q., CLONIDINE AND THE HYPERRESPONSIVENESS OF DORSAL HORN NEURONS FOLLOWING MORPHINE-WITHDRAWAL IN THE SPINAL CAT, NEUROPHARMACOLOGY 26: 1499 (1987).

ZIEGLGANSBERGAR, W, ENCEPHALIN-INDUCED INHIBITION OF CORTICAL-NEURONS AND LACK OF THIS EFFECT IN MORPHINE TOLERANT-DEPENDENT RATS, BRAIN RESEARCH 115: 160 (1976).

10.1126/science.451610

ZITO, K.A., DISRUPTION OF COCAINE AND HEROIN SELF-ADMINISTRATION FOLLOWING KAINIC ACID LESIONS OF THE NUCLEUS ACCUMBENS, PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 23: 1029 (1985).

ZUKIN, R.S., NEUROCHEMICAL CORRELATES OF OPIATE RECEPTOR REGULATION, BIOCHEMICAL PHARMACOLOGY 35: 1623 (1986).