Marisa Bowers1, Bin Zhang1, Yinwei Ho1, Puneet Agarwal2, Ching-Cheng Chen1, Ravi Bhatia2
1Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA; and
2Division of Hematology-Oncology, Department of Medicine, University of Alabama Birmingham, Birmingham, AL
Tóm tắt
Key Points
Bone marrow OB ablation leads to reduced quiescence, long-term engraftment, and self-renewal capacity of hematopoietic stem cells. Significantly accelerated leukemia development and reduced survival are seen in transgenic BCR-ABL mice following OB ablation.
