Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles
Tóm tắt
A series of new N-substituted pyrazole-containing benzimidazoles was synthesized starting from 1,2-diaminobenzene and pyrazole-4-carbaldehyde in good yield. Antioxidant activity of all title compounds was assessed using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide assays. Some of the synthesized compounds having benzyl substituent at the imidazole nitrogen exhibited good activity in both assays.
Tài liệu tham khảo
Püsküllü, M. O.; Karaaslan, C.; Bakar, F.; Göker, H. Chem. Heterocycl. Compd. 2015, 51, 723. [Khim. Geterotsikl. Soedin. 2015, 51, 723.]
Rezazadeh, M.; Pordel, M.; Davoodnia, A.; Saberi, S. Chem. Heterocycl. Compd. 2015, 51, 918. [Khim. Geterotsikl. Soedin. 2015, 51, 918.]
Brukshtus, A.; Sirvidite, A.; Garalene, V.; Labanauskas, L. Chem. Heterocycl. Compd. 1997, 33, 665. [Khim. Geterotsikl. Soedin. 1997, 765.]
Ashok, D.; Padmavati, K.; Vijaya Lakshmi, B.; Sarasija, M. Chem. Heterocycl. Compd. 2016, 52, 15. [Khim. Geterotsikl. Soedin. 2016, 52, 15.]
Ivanova, A. E.; Burgart, Y. V.; Saloutin, V. I. Chem. Heterocycl. Compd. 2013, 49, 1128. [Khim. Geterotsikl. Soedin. 2013, 1212.]
Panda, N.; Karmakar, S.; Jena, A. K. Chem. Heterocycl. Compd. 2011, 46, 1500. [Khim. Geterotsikl. Soedin. 2010, 1857.]
Gurvinder, S.; Maninderjit, K.; Mohan, C. Int. Res. J. Pharm. 2013, 4, 82.
Ansari, K. F.; Lal, C. Eur. J. Med. Chem. 2009, 44, 2294.
Jesudason, E. P.; Sridhar, S. K.; Padma Malar, E. J.; Shanmugapandiyan, P.; Inayathullah, M.; Arul, V.; Selvaraj, D.; Jayakumar, R. Eur. J. Med. Chem. 2009, 44, 2307.
Cho, S. Y.; Kang, S. K.; Kim, S. S.; Cheon, H. G.; Choi, J. K.; Yum, E. K. Bull. Korean Chem. Soc. 2001, 22, 1217.
Pandey, J.; Tiwari, V. K.; Verma, S. S.; Chaturvedi, V.; Bhatnagar, S.; Sinha, S.; Gaikwad, A. N.; Tripathi, R. P. Eur. J. Chem. 2009, 44, 3350.
Xu, Y. S.; Zeng, C. C.; Jiao, Z. G.; Hu, L. M.; Zhong, R. Molecules 2009, 14, 868.
Andreadou, I.; Tasouli, A.; Bofilis, E.; Chrysselis, M.; Rekka, E.; Tsantili-Kakoulidou, K.; Iliodromitis, E.; Siatra, T.; Kremastinos, D. T. Chem. Pharm. Bull. 2002, 50, 165.
Sharma, M. C.; Kohli, D. V.; Sharma, S. Int. J. Drug. Delivery 2010, 2, 228. doi:10.5138/ijdd.2010.0975.0215.02033
Zhang, Z.; Koh, C. Y.; Ranad, R. M.; Shibata, S.; Gillespie, J. R.; Hulverson, M. A.; Huang, W.; Nguyen, J.; Pendem, N.; Gelb, M. H.; Verlinde, C. L. M. J.; Hol, W. G. J.; Buckner, F. S.; Fan, E. ACS Infect. Dis. 2016, 2, 399.
Kus, C.; Ayhan-Kilcigil, G.; Eke, B. C.; Işcan, M. Arch. Phrma. Res. 2004, 27, 156.
Jing, X.; Zhu, Q.; Xu, F.; Ren, X.; Li, D.; Yan, C. Synth. Commun. 2006, 36, 2597.
Tandon, V. K.; Kumar, M. Tetrahedron Lett. 2004, 45, 4185.
Bougrin, K.; Loupy, A.; Petit, A.; Daou, B.; Soufiaoui, M. Tetrahedron 2001, 57, 163.
Rastogi, R.; Sharma, S. Synthesis 1983, 861.
Wu, Z.; Rea, P.; Wickham, G. Tetrahedron Lett. 2000, 41, 9871.
Mazurov, A. Bioorg. Med. Chem. Lett. 2000, 10, 67.
Maru, M.; Shah, M. K. J. Chem. Pharm. Res. 2012, 4, 1638.
Rajasekaran, S.; Gopalkrishna, R.; Abhiskek, C. Int. J. Drug Dev. Res. 2012, 4, 303.
Yen, G. C.; Chen, H. Y. J. Agric. Food. Chem. 1995, 43, 27.
Vijayabhaskaran, M.; Venkateshwaramurthy, N.; Babu, G.; Perumal, P.; Jayakar, B. Int. J. Curr. Pharm. Res. 2012, 2(3), 21.