Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis

Journal of Lipid Research - Tập 42 - Trang 1717-1726 - 2001
Alan D. Attie1, John P. Kastelein2, Michael R. Hayden3
1Departments of Biochemistry and Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706
2Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
3Centre for Molecular Medicine and Therapeutics, University of British Columbia, 980 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada; Xenon Genetics, Inc., Vancouver BC, Canada V6T 1Z3

Tài liệu tham khảo

Davidson, 1996, The role of apolipoprotein AI domains in lipid binding, Proc. Natl. Acad. Sci. USA, 93, 13605, 10.1073/pnas.93.24.13605

Jiang, 1999, Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels, J. Clin. Invest., 103, 907, 10.1172/JCI5578

Gregg, 1994, The molecular basis of abetalipoproteinemia, Curr. Opin. Lipidol., 5, 81, 10.1097/00041433-199404000-00003

Sakai, 1997, Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency, J. Biol. Chem., 272, 7506, 10.1074/jbc.272.11.7506

Kuivenhoven, 1997, The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes, J. Lipid Res., 38, 191, 10.1016/S0022-2275(20)37433-2

Goldberg, 1991, Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits, J. Clin. Invest., 87, 331, 10.1172/JCI114991

Guyard-Dangremont, 1998, Phospholipid and cholesteryl ester transfer activities in plasma from 14 vertebrate species. Relation to atherogenesis susceptibility, Comp. Biochem. Physiol. B Biochem. Mol. Biol., 120, 517, 10.1016/S0305-0491(98)10038-X

Plump, 1999, Increased atherosclerosis in apoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression, Arterioscler. Thromb. Vasc. Biol., 19, 1105, 10.1161/01.ATV.19.4.1105

Berard, 1997, High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase, Nat. Med., 3, 744, 10.1038/nm0797-744

Hayek, 1993, Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes and metabolism, J. Clin. Invest., 92, 1143, 10.1172/JCI116683

Mann, 1991, Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia, J. Clin. Invest., 88, 2059, 10.1172/JCI115535

Sparks, 1991, Lipid transfer proteins, hypertriglyceridemia, and reduced high-density lipoprotein cholesterol, Am. Heart J., 122, 601, 10.1016/0002-8703(91)91031-H

Bar-On, 1976, Serum lipoproteins and apolipoproteins in rats with streptozotocin-induced diabetes, J. Clin. Invest., 57, 714, 10.1172/JCI108329

Glass, 1983, Dissociation of tissue uptake of cholesterol ester from that of apoprotein A-I of rat plasma high density lipoprotein: selective delivery of cholesterol ester to liver, adrenal, and gonad, Proc. Natl. Acad. Sci. USA, 80, 5435, 10.1073/pnas.80.17.5435

Kozarsky, 1997, Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels, Nature, 387, 414, 10.1038/387414a0

Temel, 1997, Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells, Proc. Natl. Acad. Sci. USA, 94, 13600, 10.1073/pnas.94.25.13600

Thuren, 2000, Hepatic lipase and HDL metabolism, Curr. Opin. Lipidol., 11, 277, 10.1097/00041433-200006000-00008

Clay, 1992, Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apo A-I from HDL and subsequent formation of discoidal HDL, Biochim. Biophys. Acta., 1124, 52, 10.1016/0005-2760(92)90125-F

Bamberger, 1985, Mechanism of the hepatic lipase induced accumulation of high-density lipoprotein cholesterol by cells in culture, Biochemistry, 24, 3693, 10.1021/bi00335a044

Lambert, 2000, Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo, J. Lipid Res., 41, 667, 10.1016/S0022-2275(20)32375-0

Alexander, 1976, Subcellular localization of B apoprotein of plasma lipoproteins in rat liver, J. Cell Biol., 69, 241, 10.1083/jcb.69.2.241

Schreyer, 1994, Hypercatabolism of lipoprotein-free apolipoprotein A-I in HDL-deficient mutant chickens, Arterioscler. Thromb., 14, 2053, 10.1161/01.ATV.14.12.2053

Remaley, 1997, Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux, Arterioscler. Thromb. Vasc. Biol., 17, 1813, 10.1161/01.ATV.17.9.1813

Bale, 1971, Pathology of Tangier disease, J. Clin. Pathol., 24, 609, 10.1136/jcp.24.7.609

Christiansen-Weber, 2000, Functionalloss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high density lipoprotein cholesterol deficiency, Am. J. Pathol., 157, 1017, 10.1016/S0002-9440(10)64614-7

Marsh, 1974, Lipoproteins in a nonrecirculating perfusate of rat liver, J. Lipid Res., 15, 544, 10.1016/S0022-2275(20)36754-7

Wang, 2000, Specific binding of apoAI, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1, J. Biol. Chem., 275, 33053, 10.1074/jbc.M005438200

Chambenoit, 2001, Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter, J. Biol. Chem., 276, 9955, 10.1074/jbc.M010265200

Chen, 2000, Scavenger receptor-BI inhibits ATP-binding cassette transporter 1-mediated cholesterol efflux in macrophages, J. Biol. Chem., 275, 30794, 10.1074/jbc.M004552200

Silver, 2001, High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class b type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion, J. Biol. Chem., 276, 25287, 10.1074/jbc.M101726200

Brinton, 1994, Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution, Arterioscler. Thromb., 14, 707, 10.1161/01.ATV.14.5.707

Fan, 1994, Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins, Proc. Natl. Acad. Sci. USA, 91, 8724, 10.1073/pnas.91.18.8724

Busch, 1994, Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice, J. Biol. Chem., 269, 16376, 10.1016/S0021-9258(17)34018-8

Hoeg, 1996, Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits, J. Biol. Chem., 271, 4396, 10.1074/jbc.271.8.4396

Singaraja, 2001, Human ABCA1 BAC transgenic mice show increased HDL-C and ApoAI dependent efflux stimulated by an internal promoter containing LXREs in intron 1, J. Biol. Chem., 10.1074/jbc.M102503200

Cavelier, 2001, Regulation and activity of the human ABCA1 gene in transgenic mice, J. Biol. Chem., 276, 18046, 10.1074/jbc.M100565200

Clee, 2001, Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease, Circulation, 103, 1198, 10.1161/01.CIR.103.9.1198

Rigotti, 1999, Getting a handle on “good” cholesterol with the high-density lipoprotein receptor, N. Engl. J. Med., 341, 2011, 10.1056/NEJM199912233412612

Alam, 2001, Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice, J. Biol. Chem., 276, 15641, 10.1074/jbc.M010230200

Trigatti, 1999, Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology, Proc. Natl. Acad. Sci. USA, 96, 9322, 10.1073/pnas.96.16.9322

Arai, 1999, Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene, J. Biol. Chem., 274, 2366, 10.1074/jbc.274.4.2366

Kozarsky, 2000, Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse, Arterioscler. Thromb. Vasc. Biol., 20, 721, 10.1161/01.ATV.20.3.721

Zhong, 1996, Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels, J. Clin. Invest., 97, 2917, 10.1172/JCI118751

Bojanovski, 1987, In vivo metabolism of proapolipoprotein A-I in Tangier disease, J. Clin. Invest., 80, 1742, 10.1172/JCI113266

Jiang, 2001, Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency, Nat. Med., 7, 847, 10.1038/89977

Assmann, 1977, Characterization of high density lipoproteins in patients heterozygous for Tangier disease, J. Clin. Invest., 60, 1025, 10.1172/JCI108853

Suarez, 1982, Tangier disease: heterozygote detection and linkage analaysis, Hum. Genet., 60, 150, 10.1007/BF00569702

Schaefer, 1980, Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease), Ann. Intern. Med., 93, 261, 10.7326/0003-4819-93-2-261

Marcil, 1999, Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux, Lancet, 354, 1341, 10.1016/S0140-6736(99)07026-9

van Dam, 2001, Increased arterial wall thickness in subjects with impairment in ABCA1 driven cholesterol efflux, Lancet