Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells

Molecular Therapy - Tập 20 - Trang 1778-1790 - 2012
Grazia Andolfi1, Georgia Fousteri1, Maura Rossetti1,2, Chiara F Magnani1, Tatiana Jofra3, Grazia Locafaro1, Attilio Bondanza4, Silvia Gregori1, Maria-Grazia Roncarolo1,2
1San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
2Università Vita-Salute San Raffaele, Milan, Italy
3San Raffaele Diabetes Research Institute (HSR-DRI), Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
4Experimental Hematology Unit, PIBIC, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy

Tài liệu tham khảo

Saraiva, 2010, The regulation of IL-10 production by immune cells, Nat Rev Immunol, 10, 170, 10.1038/nri2711 de Waal Malefyt, 1991, Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes, J Exp Med, 174, 1209, 10.1084/jem.174.5.1209 Fiorentino, 1991, IL-10 inhibits cytokine production by activated macrophages, J Immunol, 147, 3815, 10.4049/jimmunol.147.11.3815 Taga, 1993, Human interleukin-10 can directly inhibit T-cell growth, Blood, 81, 2964, 10.1182/blood.V81.11.2964.bloodjournal81112964 de Waal Malefyt, 1993, Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation, J Immunol, 150, 4754, 10.4049/jimmunol.150.11.4754 Jinquan, 2000, CXC chemokine receptor 4 expression and stromal cell-derived factor-1alpha-induced chemotaxis in CD4+ T lymphocytes are regulated by interleukin-4 and interleukin-10, Immunology, 99, 402, 10.1046/j.1365-2567.2000.00954.x Groux, 1996, Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells, J Exp Med, 184, 19, 10.1084/jem.184.1.19 Groux, 1997, A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature, 389, 737, 10.1038/39614 Roncarolo, 2006, Interleukin-10-secreting type 1 regulatory T cells in rodents and humans, Immunol Rev, 212, 28, 10.1111/j.0105-2896.2006.00420.x Roncarolo, 1988, Antigen recognition by MHC-incompatible cells of a human mismatched chimera, J Exp Med, 168, 2139, 10.1084/jem.168.6.2139 Bacchetta, 1994, High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells, J Exp Med, 179, 493, 10.1084/jem.179.2.493 Serafini, 2009, Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia, Haematologica, 94, 1415, 10.3324/haematol.2008.003129 Bacchetta, 2002, Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines, Eur J Immunol, 32, 2237, 10.1002/1521-4141(200208)32:8<2237::AID-IMMU2237>3.0.CO;2-2 Magnani, 2011, Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells, Eur J Immunol, 41, 1652, 10.1002/eji.201041120 Di Ianni, 2011, Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation, Blood, 117, 3921, 10.1182/blood-2010-10-311894 Brunstein, 2011, Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics, Blood, 117, 1061, 10.1182/blood-2010-07-293795 Bacchetta, 2009, Interleukin-10 anergized donor T cell infusion improves immune reconstitution without severe graft-versus-host disease after haploidentical hematopoietic stem cell transplantation, Blood, 114, 45, 10.1182/blood.V114.22.45.45 Levings, 2001, IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells, J Immunol, 166, 5530, 10.4049/jimmunol.166.9.5530 Barrat, 2002, In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines, J Exp Med, 195, 603, 10.1084/jem.20011629 Kemper, 2003, Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype, Nature, 421, 388, 10.1038/nature01315 Pot, 2009, Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells, J Immunol, 183, 797, 10.4049/jimmunol.0901233 Levings, 2005, Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells, Blood, 105, 1162, 10.1182/blood-2004-03-1211 Bacchetta, 2010, Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy, Haematologica, 95, 2134, 10.3324/haematol.2010.025825 Gregori, 2010, Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway, Blood, 116, 935, 10.1182/blood-2009-07-234872 Ito, 2007, Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand, J Exp Med, 204, 105, 10.1084/jem.20061660 Brandt, 2005, Allo-specific T-cells encoding for viral IL-10 exert strong immunomodulatory effects in vitro but fail to prevent graft rejection, Am J Transplant, 5, 268, 10.1111/j.1600-6143.2005.00689.x Setoguchi, 2000, Antigen-specific T cells transduced with IL-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen, J Immunol, 165, 5980, 10.4049/jimmunol.165.10.5980 Guichelaar, 2008, Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response, J Immunol, 180, 1373, 10.4049/jimmunol.180.3.1373 Van Montfrans, 2002, Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model, Gastroenterology, 123, 1865, 10.1053/gast.2002.37067 Oh, 2002, CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation, J Allergy Clin Immunol, 110, 460, 10.1067/mai.2002.127512 Zhao, 2005, Lentivirus-mediated gene transfer of viral interleukin-10 delays but does not prevent cardiac allograft rejection, Gene Ther, 12, 1509, 10.1038/sj.gt.3302547 Trittibach, 2008, Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis, Gene Ther, 15, 1478, 10.1038/gt.2008.109 Cavalieri, 2003, Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence, Blood, 102, 497, 10.1182/blood-2003-01-0297 Marktel, 2003, Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation, Blood, 101, 1290, 10.1182/blood-2002-08-2351 Amendola, 2005, Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters, Nat Biotechnol, 23, 108, 10.1038/nbt1049 Akdis, 2004, Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells, J Exp Med, 199, 1567, 10.1084/jem.20032058 Häringer, 2009, Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood, J Exp Med, 206, 1009, 10.1084/jem.20082238 Bondanza, 2006, Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes, Blood, 107, 1828, 10.1182/blood-2005-09-3716 Misaki, 2000, [Antigen-specific T cells transduced with interleukin-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen], Nihon Rinsho Meneki Gakkai Kaishi, 23, 538, 10.2177/jsci.23.538 Bonini, 2007, The suicide gene therapy challenge: how to improve a successful gene therapy approach, Mol Ther, 15, 1248, 10.1038/sj.mt.6300190 Montini, 2006, Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration, Nat Biotechnol, 24, 687, 10.1038/nbt1216 Frauwirth, 2004, Regulation of T lymphocyte metabolism, J Immunol, 172, 4661, 10.4049/jimmunol.172.8.4661 Battaglia, 2006, Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance, Diabetes, 55, 40, 10.2337/diabetes.55.01.06.db05-0613 Brooks, 2006, Interleukin-10 determines viral clearance or persistence in vivo, Nat Med, 12, 1301, 10.1038/nm1492 Ejrnaes, 2006, Resolution of a chronic viral infection after interleukin-10 receptor blockade, J Exp Med, 203, 2461, 10.1084/jem.20061462 McMurchy, 2011, Moving to tolerance: clinical application of T regulatory cells, Semin Immunol, 23, 304, 10.1016/j.smim.2011.04.001 Ciceri, 2009, Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study, Lancet Oncol, 10, 489, 10.1016/S1470-2045(09)70074-9 De Palma, 2002, Transduction of a gene expression cassette using advanced generation lentiviral vectors, Meth Enzymol, 346, 514, 10.1016/S0076-6879(02)46074-0 Gentner, 2009, Stable knockdown of microRNA in vivo by lentiviral vectors, Nat Methods, 6, 63, 10.1038/nmeth.1277 Tanaka, 1993, Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice, J Exp Med, 178, 1103, 10.1084/jem.178.3.1103