Role of c-SRC and ERK in acid-induced activation of NHE3

Alpern, 1997, The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity, Am J Kidney Dis, 29, 291, 10.1016/S0272-6386(97)90045-7 Akiba, 1987, Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis, J Clin Invest, 80, 308, 10.1172/JCI113074 Preisig, 1988, Chronic metabolic acidosis causes an adaptation in the apical membrane Na/H antiporter and basolateral membrane Na(HCO3)3 symporter in the rat proximal convoluted tubule, J Clin Invest, 82, 1445, 10.1172/JCI113750 Ambühl, 1996, Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney, Am J Physiol, 271, F917 Wu, 1996, Role of NHE3 in mediating renal brush border Na+-H+ exchange. Adaptation to metabolic acidosis, J Biol Chem, 271, 32749, 10.1074/jbc.271.51.32749 Amemiya, 1995, Acid incubation increases NHE-3 mRNA abundance in OKP cells, Am J Physiol, 269, C126, 10.1152/ajpcell.1995.269.1.C126 Yamaji, 1994, Acid activation of immediate early genes in renal epithelial cells, J Clin Invest, 94, 1297, 10.1172/JCI117448 Yamaji, 1995, Overexpression of csk inhibits acid-induced activation of NHE-3, Proc Natl Acad Sci USA, 92, 6274, 10.1073/pnas.92.14.6274 Yamaji, 1997, Intracellular acidosis activates c-Src, Am J Physiol, 272, C886, 10.1152/ajpcell.1997.272.3.C886 Cole, 1989, Clonal sublines that are morphologically and functionally distinct from parental OK cells, Am J Physiol, 256, F672 Alessi, 1995, PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo, J Biol Chem, 270, 27489, 10.1074/jbc.270.46.27489 Curran, 1987, Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro, Oncogene, 2, 79 Moe, 1991, Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts, J Clin Invest, 88, 1703, 10.1172/JCI115487 Horie, 1990, Preincubation in acid medium increases Na/H antiporter activity in cultured renal proximal tubule cells, Proc Natl Acad Sci USA, 87, 4742, 10.1073/pnas.87.12.4742 Amemiya, 1995, Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb, Kidney Int, 48, 1206, 10.1038/ki.1995.404 Biemesderfer, 1993, NHE3: A Na/H exchanger isoform of the renal brush border, Am J Physiol, 265, F736 Nada, 1991, Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src, Nature, 351, 69, 10.1038/351069a0 Okada, 1991, CSK: A protein-tyrosine kinase involved in regulation of src family kinases, J Biol Chem, 266, 24249, 10.1016/S0021-9258(18)54220-4 Bergman, 1995, Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of avb5 integrin, and interferes with HeLa cell spreading, Molec Cell Biol, 15, 711, 10.1128/MCB.15.2.711 Twamley-Stein, 1993, The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells, Proc Natl Acad Sci USA, 90, 7696, 10.1073/pnas.90.16.7696 Roche, 1995, DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases, Mol Cell Biol, 15, 1102, 10.1128/MCB.15.2.1102 Chu, 1996, EndothelinB receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells, J Clin Invest, 97, 1454, 10.1172/JCI118567 Horie, 1992, Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity, Proc Natl Acad Sci USA, 89, 5236, 10.1073/pnas.89.12.5236 Whitmarsh, 1996, Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways, J Mol Med, 74, 589, 10.1007/s001090050063 Tsuganezawa, 1998, Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells, Kidney Int, 54, 394, 10.1046/j.1523-1755.1998.00029.x Baum, 1993, Glucocorticoids stimulate Na/H antiporter in OKP cells, Am J Physiol, 264, F1027 Lotspeich, 1965, Renal hypertrophy in metabolic acidosis and its relation to ammonia excretion, Am J Physiol, 208, 1135, 10.1152/ajplegacy.1965.208.6.1135 Laghmani, 2001, Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis, J Clin Invest, 107, 1563, 10.1172/JCI11234 Barone, 1995, Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src, Nature, 378, 509, 10.1038/378509a0 Yang, 2000, Acid incubation causes exocytic insertion of NHE3 in OKP cells, Am J Physiol, 279, C410, 10.1152/ajpcell.2000.279.2.C410