Structural basis for the functional properties of the P2X7 receptor for extracellular ATP

Purinergic Signalling - Tập 17 Số 3 - Trang 331-344 - 2021
Jiang, Lin-Hua1, Caseley, Emily A.1,2, Muench, Steve P.1, Roger, Sébastien3
1School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, UK
2Faculty of Medicine and Health, Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James’s University Hospital, Leeds, UK
3EA4245, Transplantation, Immunology and Inflammation, Faculty of Medicine, University of Tours, Tours, France

Tóm tắt

The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction with site-directed mutagenesis, molecular modelling, and, recently, structural determination, have provided significant insights into the structure–function relationships of the P2X7 receptor. This review discusses the current understanding of the structural basis for the functional properties of the P2X7 receptor.

Tài liệu tham khảo

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