Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

SAGE Publications - Tập 11 Số 1 - Trang 57-91 - 2000
Barry J. Sessle1
1Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1 G6

Tóm tắt

This paper reviews the recent advances in knowledge of brainstem mechanisms related to craniofacial pain. It also draws attention to their clinical implications, and concludes with a brief overview and suggestions for future research directions. It first describes the general organizational features of the trigeminal brainstem sensory nuclear complex (VBSNC), including its input and output properties and intrinsic characteristics that are commensurate with its strategic role as the major brainstem relay of many types of somatosensory information derived from the face and mouth. The VBSNC plays a crucial role in craniofacial nociceptive transmission, as evidenced by clinical, behavioral, morphological, and electrophysiological data that have been especially derived from studies of the relay of cutaneous nociceptive afferent inputs through the subnucleus caudalis of the VBSNC. The recent literature, however, indicates that some fundamental differences exist in the processing of cutaneous vs. other craniofacial nociceptive inputs to the VBSNC, and that rostral components of the VBSNC may also play important roles in some of these processes. Modulatory mechanisms are also highlighted, including the neuro-chemical substrate by which nociceptive transmission in the VBSNC can be modulated. In addition, the long-term consequences of peripheral injury and inflammation and, in particular, the neuroplastic changes that can be induced in the VBSNC are emphasized in view of the likely role that central sensitization, as well as peripheral sensitization, can play in acute and chronic pain. The recent findings also provide new insights into craniofacial pain behavior and are particularly relevant to many approaches currently in use for the management of pain and to the development of new diagnostic and therapeutic procedures aimed at manipulating peripheral inputs and central processes underlying nociceptive transmission and its control within the VBSNC.

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Tài liệu tham khảo

10.1016/S0006-8993(97)00091-7

10.1002/(SICI)1098-2396(199609)24:1<39::AID-SYN5>3.0.CO;2-H

10.1016/0306-4522(92)90256-2

10.1016/0304-3940(94)90815-X

10.1523/JNEUROSCI.15-05-03328.1995

Azerad J., Boucher Y., Pollin B. (1992). Occurrence of glutamate in primary sensory trigeminal neurons innervating the rat dental pulp. Comptes Rendus de l'Academie des Sciences Paris, Serie III 314:469-475.

10.1016/S0304-3959(97)00223-6

10.1097/00001756-199810050-00030

10.1523/JNEUROSCI.15-04-02972.1995

Bennett GJ (1994). Neuropathic pain. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 201-224.

Bennett-Clarke CA, Chiaia NL (1992). Normal development and effects of neonatal infraorbital nerve damage upon the innervation of the trigeminal brainstem complex by primary afferent fibers containing calcitonin gene-related peptide. J Comp Neurol 342:282-294.

10.1016/S0306-4522(96)00541-6

10.1016/0304-3959(96)03156-9

10.1016/0306-4522(96)00038-3

10.1016/0006-8993(94)90955-5

10.1152/jn.1995.73.2.568

10.1152/jn.1993.69.1.174

Bonica JJ (1983). Pain research and therapy: achievements of the past and challenges of the future. In: Advances in pain research and therapy. Vol. 5. Bonica JJ, Lindblom U, Iggo A, editors. New York: Raven Press, pp. 1-36.

10.1016/0003-9969(88)90008-8

10.1152/jn.1988.59.5.1575

10.1002/cne.903560302

10.1002/cne.902620302

10.1152/jn.1998.79.2.964

10.1016/0006-8993(95)00055-U

10.1523/JNEUROSCI.18-19-08056.1998

10.1177/10454411920040010101

Carlsson GE, LeResche L. (1995). Epidemiology of temporomandibular disorders. In: Temporomandibular disorders and related pain conditions. Progress in pain research and management. Vol. 4. Sessle B), Bryant PS, Dionne RA, editors. Seattle: IASP Press, pp. 211-226.

10.1016/0306-4522(95)00297-V

10.1038/356521a0

10.1016/0006-8993(89)90581-7

10.1016/0006-8993(91)90886-Z

10.1152/jn.1994.71.6.2430

10.1152/jn.1997.78.5.2799

10.1152/jn.1998.80.5.2621

10.1152/jn.1999.82.5.2154

10.1016/0304-3940(89)90125-0

10.1017/S0140525X97281495

10.1002/cne.903090209

10.1017/S0140525X97251484

10.1016/0304-3959(93)90161-H

10.1016/0304-3940(94)90183-X

Cooper BY, Sessle BJ (1992). Anatomy, physiology, and pathophysiology of trigeminal system paresthesias and dysesthesias. In: Oral and maxillofacial surgery clinics of North America. Trigeminal nerve injury: diagnosis and management. Vol. 4, No. 2. LaBanc JP, Gregg JM, Saunders WB, editors. Philadelphia: W.B. Saunders, pp. 297-322.

Craig AD, Dostrovsky JO (1997). Processing of nociceptive information at supraspinal levels. In: Anesthesia: biologic foundations. Yaksh TL, Lynch C 111, Zapol WM, Maze M, Biebuyck JF, Saidman LJ, editors. Philadelphia: Lippincott-Raven, pp. 625-642.

10.1111/j.1476-5381.1995.tb13302.x

10.1016/0006-8993(88)91096-7

10.1016/0014-4886(89)90147-7

10.1016/0006-8993(90)91529-P

10.1016/S0014-2999(96)00480-3

Dallel R., De Chazeron I., Sierralta F., Raboisson P. (1997). Diencephalic projections of the rat spinal trigeminal nucleus oralis studied with the PHA-L method (abstract). Soc Neurosci Abstr 23:154.

10.1523/JNEUROSCI.18-10-03529.1998

10.1016/S0074-7742(08)60141-5

10.1093/brain/96.4.783

Dickenson AH (1994). Where and how do opioids act? In: Progress in pain research and management. Vol. 2. Proceedings of the 7th World Congress on Pain, Aug 22-27, 1993, Paris. Gebhart GF, Hammond DL, Jensen TS, editors. Seattle: IASP Press, pp. 525-552.

10.1002/syn.890060408

10.1002/(SICI)1096-9861(19960408)367:3<375::AID-CNE5>3.0.CO;2-2

10.1016/0304-3940(94)91070-7

10.1152/jn.1984.51.5.859

10.1139/y91-097

10.1006/exnr.1996.0202

Dubner R. (1985). Recent advances in our understanding of pain. In: Oro-facial pain and neuromuscular dysfunction: mechanisms and clinical correlates. Klineberg I, Sessle B, editors. Oxford: Pergamon Press, pp. 3-19.

Dubner R. (1997). Neural basis of persistent pain: sensory specialization, sensory modulation, and neuronal plasticity. In: Progress in pain research and management. Vol. 8. Proceedings of the 8th World Congress on Pain, Aug 17-22, 1996, Vancouver. Jensen TS, Turner JA, Wiesenfeld-Hallin A, editors. Seattle: IASP Press, pp. 243-257.

Dubner R., Basbaum AI (1994). Spinal dorsal horn plasticity following tissue or nerve injury. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 225-241.

10.1146/annurev.ne.06.030183.002121

Dubner R., Sessle BJ, Storey AT (1978). The neural basis of oral and facial function. New York: Plenum Press.

10.1002/(SICI)1097-4547(19960901)45:5<610::AID-JNR10>3.0.CO;2-2

10.1016/0006-8993(95)00118-A

10.1016/0306-4522(95)00565-X

10.1002/jemt.1060100302

Fields HL, Basbaum AI (1994). Central nervous system mechanisms of pain modulation. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 243-257.

Fromm GH, Sessle BJ (1991). Trigeminal neuralgia. Current concepts regarding pathogenesis and treatment. Stoneham: Butterworth-Heinemann.

10.1016/0028-3908(92)90086-5

10.1002/cne.901830112

10.1007/BF00268020

10.1093/brain/114.2.1001

Gobel S., Hockfield S., Ruda MA ( 1981). Anatomical similarities between medullary and spinal dorsal horns. In: Oral-facial sensory and motor functions. Kawamura Y, Dubner R, editors. Tokyo: Quintessence, pp. 211-223.

Gobel S., Bennett GJ, Allen B., Humphrey E., Seltzer Z., Abdelmoumene M., et al. (1982). Synaptic connectivity of substantia gelatinosa neurons with reference to potential termination sites of descending axons. In: Brain stem control of spinal mechanisms. Sjolund B, Bjorklund A, editors. Amsterdam: Elsevier, pp. 135-158.

10.1212/WNL.38.10.1529

10.1523/JNEUROSCI.14-03-01646.1994

10.1113/jphysiol.1995.sp020716

Guilbaud G., Bernard JF, Besson JM (1994). Brain areas involved in nociception and pain. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 113-128.

Hannam AG, Sessle BJ (1994). Temporomandibular neurosensory and neuromuscular physiology. In: Temporomandibular joint and masticatory muscle disorders. Zarb GE, Carlsson G, Sessle BJ, Mohl ND, editors. Copenhagen: Munksgaard, pp. 67-100.

Hargreaves KM, Roszkowski MT, Jackson DL, Bowles W., Richardson JD, Swift JQ (1995). Neuroendocrine and immune response to injury, degeneration, and repair. In: Temporomandibular disorders and related pain conditions. Progress in pain research and management. Vol. 4. Sessle BJ, Bryant PS, Dionne RA, editors. Seattle: IASP Press, pp. 273-292.

10.1002/cne.903560311

10.1002/cne.902400106

Hayashi H. (1992). Somatosensory pathways from the trigeminal nucleus to the mesencephalic parabrachial area. In: Processing and inhibition of nociceptive information. Inoki R, Shigenaga Y, Tohyama M, editors. Amsterdam: Elsevier, pp. 109-114.

Henderson TA, lacquin MF (1995). What makes subcortical barrels? Requisite trigeminal circuitry and developmental mechanisms. In: Cerebral cortex. Vol. 11. lones EG, Diamond IT, editors. New York: Plenum Press, pp. 123-187.

10.1016/0304-3959(80)90088-3

10.1002/(SICI)1096-9861(19960219)365:4<526::AID-CNE2>3.0.CO;2-6

10.1093/brain/119.5.1419

10.1016/0304-3959(90)90010-B

10.1152/jn.1984.52.1.39

10.1016/0014-4886(88)90050-7

10.1152/jn.1989.61.6.1197

10.1016/0006-8993(90)90928-5

10.1016/0304-3959(92)90131-T

Hu JW, Shohara E., Sessle BJ (1992b). Patterns and plasticity of dental afferent inputs to trigeminal (V) brainstem neurons in kittens. Proc Finn Dent Soc 88(Suppl 1):563-569.

Hu JW, Tsai CM, Bakke M., Seo K., Tambeli CH, Vernon H., et al. (1997). Deep craniofacial pain: involvement of trigeminal subnucleus caudalis and its modulation. In: Progress in pain research and management. Vol. 8. Proceedings of the 8th World Congress on Pain, Aug 17-22, 1996, Vancouver. Jensen TS, Turner JA, Wiesenfeld-Hallin A, editors. Seattle: IASP Press, pp. 497-506.

10.1016/S0003-9969(98)00111-3

10.1016/0006-8993(95)00176-Q

10.1002/cne.902670108

10.3109/08990229009144716

10.1523/JNEUROSCI.17-10-03751.1997

Jensen TS, Turner JA, Wiesenfeld-Hallin A, editors (1997). Progress in pain research and management. Vol. 8. Proceedings of the 8th World Congress on Pain, Aug 17-22, 1996, Vancouver. Seattle: IASP Press.

Johnson LR, Westrum LE, Henry MA (1991). Anatomic organization of the trigeminal system and the effects of deafferentation. In: Trigeminal neuralgia. Current concepts regarding pathogenesis and treatment. Fromm GH, Sessle BJ, editors. Stoneham: Butterworth-Heinemann, pp. 27-69.

10.1016/0003-9969(94)00134-W

Katz ) J. (1995). Pre-emptive analgesia: evidence, current status and future directions. Eur J Anaesthesiol 12(Suppl 10):8-13.

10.1016/0306-4522(89)90115-2

10.1016/0304-3940(96)13056-1

10.1016/0361-9230(90)90167-X

10.1016/0304-3940(95)11316-O

10.1002/cne.902730203

10.3109/08990229309028828

10.1152/jn.1996.75.1.298

10.1152/jn.1999.81.2.435

10.1016/S0040-8166(96)80059-0

Levine J., Taiwo Y. (1994). Inflammatory pain. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 45-56.

10.14219/jada.archive.1993.0200

10.1016/0306-4522(94)00624-E

10.1177/10454411910020010401

10.1139/y91-102

10.1002/cne.903530107

10.3109/07367228709144605

10.1016/S0003-9969(97)00023-X

Maixner W., Sigurdsson A., Fillingim RB, Lundeen T., Booker DK (1995). Regulation of acute and chronic orofacial pain. In: Orofacial pain and temporomandibular disorders. Advances in pain research and therapy. Vol. 21. Fricton JR, Dubner R, editors. New York: Raven Press, pp. 85-102.

10.1002/cne.903500307

Martinez S., Belmonte C. (1996). c-fos expression in trigeminal nucleus neurons after chemical irritation of the cornea: reduction by selective blockade of nociceptor chemosensitivity. Exp Brain Res 109:56-62.

10.1016/0165-0173(85)90003-7

10.3109/08990228909144690

10.1002/cne.903470307

McQuay HJ (1994). Do preemptive treatments provide better pain control? In: Progress in pain research and management. Vol. 2. Proceedings of the 7th World Congress on Pain, Aug 22-27, 1993, Paris. Gebhart GF, Hammond DL, Jensen TS, editors. Seattle: IASP Press, pp. 709-723.

Meller ST, Gebhart GF (1993). Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52:235-240.

Melzack R. (1994). Folk medicine and the sensory modulation of pain. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 1209-1217.

10.1152/jn.1997.77.1.43

10.1016/0304-3959(93)90027-M

10.1016/0006-8993(93)90594-D

Moskowitz MA (1994). Drug mechanisms in acute migraine. In: Progress in pain research and management. Vol. 2. Proceedings of the 7th World Congress on Pain, Aug 22-27, 1993, Paris. Gebhart GF, Hammond DL, lensen TS, editors. Seattle: IASP Press, pp. 755-764.

10.1016/0003-9969(94)90030-2

10.2170/jjphysiol.41.551

10.1002/cne.903020422

Nord SG, Ross GS ( 1977). Behavioral and neurophysiological correlates of dental pulp stimulation in the monkey. In: Pain in the trigeminal regions. Anderson DJ. Matthews B, editors. Amsterdam: Elsevier/North Holland, pp. 259-270.

10.1111/j.1476-5381.1992.tb14348.x

10.1016/S0006-8993(96)00863-3

10.1016/0006-8993(95)00597-J

10.1016/S0006-8993(97)00355-7

Park SJ, Chiang CY, Kishimoto H., Hu JW, Sessle BJ (1998). NMDA involvement in pulp-induced neuroplasticity in trigeminal subnucleus oralis (abstract). J Dent Res 77(Spec Iss B):895.

10.1152/jn.1993.70.6.2260

10.1523/JNEUROSCI.14-02-00667.1994

10.3109/08990228909144682

10.1152/jn.1993.70.6.2370

10.1097/00001756-199604100-00012

Raboisson P., Dallel R., Woda A. ( 1989). Responses of neurones in the ventrobasal complex of the thalamus to orofacial noxious stimulation after large trigeminal tractotomy. Exp Brain Res 77:569-576.

10.1152/jn.1995.73.2.496

10.1523/JNEUROSCI.08-07-02234.1988

10.1016/0301-0082(93)90006-E

Schmidt RF, Schaible H-G., Messlinger K., Heppelmann B., Hanesch U., Pawlak M. (1994). Silent and active nociceptor: structure, functions and clinical implications. In: Progress in pain research and management. Vol. 2. Proceedings of the 7th World Congress on Pain, Aug 22-27, 1993, Paris. Gebhart GF, Hammond DL, Jensen TS, editors. Seattle: IASP Press, pp. 213-250.

10.1177/00220345870660052201

Sessle BI (1996). Mechanisms of trigeminal and occipital pain. Pain Rev 3:91-116.

10.1139/y91-092

Sessle BJ, Chiang CY, Dostrovsky JO (1992). Interrelationships between sensorimotor cortex, anterior pretectal nucleus and periaqueductal gray in modulation of trigeminal sensorimotor function in the rat. In: Processing and inhibition of nociceptive information. Inoki R, Shigenaga Y, Tohyama M, editors. Amsterdam: Elsevier, pp. 77-82.

Sessle BJ, Hu JW, Yu X-M. (1993). Brainstem mechanisms of referred pain and hyperalgesia in the orofacial and temporomandibular region. In: New trends in referred pain and hyperalgesia. Pain research and clinical management. Vol. 7. Vecchiet L, Albe-Fessard D, Lindblom U, editors. Amsterdam: Elsevier, pp. 59-71.

10.1016/0028-3908(94)00153-J

10.3109/08990229509093662

10.1006/exnr.1993.1157

10.3109/07367228809144630

Slugg RM, Light AR (1994). Spinal cord and trigeminal projections to the pontine parabrachial region in the rat as demonstrated with Phaseolus vulgaris leucoagglutinin. J Comp Neurol 229:49-61.

Sluka KA, Willis WD, Westlund KN (1994). Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats. J Pharmacol Exp Ther 271:76-82.

Soja PJ, Cairns BE, Christensen MP (1999). Transmission through ascending lumbar and trigeminal sensory pathways: dependence on behavioral state. In: Handbook of behavioral state control: cellular and molecular mechanisms. Lydic R, Baghdoyan HA, editors. Boca Raton, FL: CRC Press, pp. 521-544.

Stein C. (1994). Interaction of immune-competent cells and nociceptors. In: Progress in pain research and management. Vol. 2. Proceedings of the 7th World Congress on Pain, Aug 22-27, 1993, Paris. Gebhart GF, Hammond DL, Jensen TS, editors. Seattle: IASP Press, pp. 285-297.

Stohler CS (1995). Clinical perspectives on masticatory and related muscle disorders. Progress in pain research and management. Vol. 4. Sessle BJ, Bryant PS, Dionne RA, editors. Seattle: IASP Press, pp. 3-29.

10.3109/08990229209144766

10.1523/JNEUROSCI.14-06-03725.1994

10.1002/cne.903460304

Suarez-Roca H., Maixner W. (1993). Activation of kappa opioid receptors by U50488H and morphine enhances the release of substance P from rat trigeminal nucleus slices. J Pharmacol Exp Ther 264:648-653.

Sugimoto T. (1987). Effects of chemical convulsants on chronic transsynaptic destruction of medullary dorsal horn neurons following inferior alveolar neurotomy in adult rats. In: Effects of injury on trigeminal and spinal somatosensory systems. Pubols LM, Sessle BJ, editors. New York: Alan R. Liss, pp. 167-174.

10.1002/(SICI)1096-9861(19970217)378:3<425::AID-CNE9>3.0.CO;2-5

10.1016/S0168-0102(97)00064-3

10.1016/S0304-3959(98)00241-3

Svensson P., Arendt-Neilsen L., Hove L. ( 1998). Muscle pain modulates mastication: an experimental study in humans. J Orofac Pain 12:7-16.

10.3109/08990229309028833

10.1016/0304-3940(92)90339-9

10.1016/0196-9781(92)90007-P

10.1152/jn.1996.76.6.3817

10.1113/jphysiol.1996.sp021205

10.1016/0006-8993(89)90665-3

10.1016/0166-2236(94)90018-3

10.1016/0304-3959(96)03121-1

10.1523/JNEUROSCI.14-05-02708.1994

Wakisaka S., Sasaki Y., Ichikawa H., Matsuo S. (1992). Increase in c-fos-like immunoreactivity in the trigeminal nucleus complex after dental treatment. Proc Finn Dent Soc 88(Suppl 1):551-556.

10.1152/jn.1996.76.3.2093

10.1016/S0006-8993(96)00828-1

10.1146/annurev.ne.18.030195.001021

10.1097/00001756-199804200-00019

Woda A., Parada CA, Luccarini P. (1998). Intranuclear injection of MK801 in the trigeminal caudalis subnucleus decreases the wind-up of neurones in the trigeminal oralis subnucleus (abstract). J Dent Res 77(Spec Iss B):896.

Woolf CJ (1991). Central mechanisms of acute pain. In: Pain research and clinical management. Vol. 4. Proceedings of the 6th World Congress on Pain, Apr 1-6, 1990, Adelaide. Bond MR, Charlton JE, Woolf CJ, editors. Amsterdam: Elsevier, pp. 25-34.

Woolf CJ (1994). The dorsal horn: state-dependent sensory processing and the generation of pain. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 101-112.

Woolf CJ, Thompson JW (1994). Stimulation fibre-induced analgesia: transcutaneous electrical nerve stimulation (TENS) and vibration. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 1191-1208.

Woolsey TA (1990). Peripheral alteration and somatosensory development. In: Development of sensory systems in mammals. Coleman JR, editor. New York: Wiley, pp. 461-526.

Yaksh TL, Malmberg AB (1994). Central pharmacology of nociceptive transmission. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 165-200.

10.1016/0306-4522(92)90483-I

Yokota T. (1985). Neural mechanisms of trigeminal pain. In: Advances in pain research and therapy. Vol. 9. Fields HL, Dubner R, Cervero F, editors. New York: Raven Press, pp. 221-232.

10.1152/jn.1986.56.1.80

10.1002/cne.903070408

Young RF, Rinaldi PC (1994). Brain stimulation for relief of chronic pain. In: Textbook of pain. 3rd ed. Wall PD, Melzack R, editors. London: Churchill-Livingstone, pp. 1225-1233.

10.1152/jn.1993.70.4.1704

10.1152/jn.1994.72.3.1430

10.1016/0304-3959(94)00104-M

10.1016/S0304-3959(96)03181-8

10.1016/0006-8993(96)00123-0