Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial

Parikh, 2004, The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults, J Clin Endocrinol Metab, 89, 1196, 10.1210/jc.2003-031398 Saintonge, 2009, Implications of a new definition of vitamin D deficiency in a multiracial us adolescent population: the National Health and Nutrition Examination Survey III, Pediatrics, 123, 797, 10.1542/peds.2008-1195 Wortsman, 2000, Decreased bioavailability of vitamin D in obesity, Am J Clin Nutr, 72, 690, 10.1093/ajcn/72.3.690 Ogden, 2012, Prevalence of obesity in the United States, 2009–2010, NCHS Data Brief, 82 Ross, 2011, The 2011 Dietary Reference Intakes for calcium and vitamin D: what dietetics practitioners need to know, J Am Diet Assoc, 111, 524, 10.1016/j.jada.2011.01.004 Ross, 2011, The 2011 report on dietary reference intakes for calcium and vitamin D, Public Health Nutr, 14, 938, 10.1017/S1368980011000565 von Hurst, 2010, Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient—a randomised, placebo-controlled trial, Br J Nutr, 103, 549, 10.1017/S0007114509992017 Harris, 2011, Vitamin D3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults, Am J Hypertens, 24, 557, 10.1038/ajh.2011.12 Pittas, 2006, Vitamin D and calcium intake in relation to type 2 diabetes in women, Diabetes Care, 29, 650, 10.2337/diacare.29.03.06.dc05-1961 Chiu, 2004, Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction, Am J Clin Nutr, 79, 820, 10.1093/ajcn/79.5.820 Kuczmarski, 2000, CDC growth charts: United States, Adv Data, 314, 1 2007 Rockett, 1997, Validation of a youth/adolescent food frequency questionnaire, Prev Med, 26, 808, 10.1006/pmed.1997.0200 Wolf, 1994, Reproducibility and validity of a self-administered physical activity questionnaire, Int J Epidemiol, 23, 991, 10.1093/ije/23.5.991 Rajakumar, 2008, Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children, Obesity (Silver Spring), 16, 90, 10.1038/oby.2007.23 Chow S-C, Liu J-P. 2nd ed. Hoboken, NJ: Wiley Interscience, 2004. Schulz, 2005, Multiplicity in randomised trials I: endpoints and treatments, Lancet, 365, 1591, 10.1016/S0140-6736(05)66461-6 Grant, 2005, Benefits and requirements of vitamin D for optimal health: a review, Altern Med Rev, 10, 94 Bischoff-Ferrari, 2009, Vitamin D: what is an adequate vitamin D level and how much supplementation is necessary?, Best Pract Res Clin Rheumatol, 23, 789, 10.1016/j.berh.2009.09.005 Henry, 2010, 14th Vitamin D Workshop consensus on vitamin D nutritional guidelines, J Steroid Biochem Mol Biol, 121, 4, 10.1016/j.jsbmb.2010.05.008 Oda, 2008, The ratio of leptin to adiponectin can be used as an index of insulin resistance, Metabolism, 57, 268, 10.1016/j.metabol.2007.09.011 Smotkin-Tangorra, 2007, Prevalence of vitamin D insufficiency in obese children and adolescents, J Pediatr Endocrinol Metab, 20, 817, 10.1515/JPEM.2007.20.7.817 Moore, 2004, Vitamin D intake in the United States, J Am Diet Assoc, 104, 980, 10.1016/j.jada.2004.03.028 Gronowitz, 2005, Ultraviolet B radiation improves serum levels of vitamin D in patients with cystic fibrosis, Acta Paediatr, 94, 547, 10.1111/j.1651-2227.2005.tb01937.x Heaney, 2003, Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol, Am J Clin Nutr, 77, 204, 10.1093/ajcn/77.1.204 Atabek, 2007, Assessment of insulin sensitivity from measurements in fasting state and during an oral glucose tolerance test in obese children, J Pediatr Endocrinol Metab, 20, 187, 10.1515/JPEM.2007.20.2.187 Yokoyama, 2004, Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment are useful indexes of insulin resistance in type 2 diabetic patients with wide range of fasting plasma glucose, J Clin Endocrinol Metab, 89, 1481, 10.1210/jc.2003-031374 Keskin, 2005, Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents, Pediatrics, 115, e500, 10.1542/peds.2004-1921 Park, 2009, Metformin for obesity in children and adolescents: a systematic review, Diabetes Care, 32, 1743, 10.2337/dc09-0258 Flores, 2005, A role of vitamin D in low-intensity chronic inflammation and insulin resistance in type 2 diabetes mellitus?, Nutr Res Rev, 18, 175, 10.1079/NRR2005104 Huang, 2002, Effect of 1 alpha,25-dihydroxy vitamin D3 and vitamin E on insulin-induced glucose uptake in rat adipocytes, Diabetes Res Clin Pract, 55, 175, 10.1016/S0168-8227(01)00324-2 Reusch, 1991, Regulation of GLUT-4 phosphorylation by intracellular calcium in adipocytes, Endocrinlogy, 129, 3269, 10.1210/endo-129-6-3269 Maestro, 2003, Identification of a vitamin D response element in the human insulin receptor gene promoter, J Steroid Biochem Mol Biol, 84, 223, 10.1016/S0960-0760(03)00032-3 Mitri, 2011, Effects of vitamin D and calcium supplementation on pancreatic beta cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial, Am J Clin Nutr, 94, 486, 10.3945/ajcn.111.011684 Mitri, 2011, Vitamin D and type 2 diabetes: a systematic review, Eur J Clin Nutr, 65, 1005, 10.1038/ejcn.2011.118 Zeitz, 2003, Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor, FASEB J, 17, 509, 10.1096/fj.02-0424fje Caballero, 2008, Overweight Latino children and adolescents have marked endothelial dysfunction and subclinical vascular inflammation in association with excess body fat and insulin resistance, Diabetes Care, 31, 576, 10.2337/dc07-1540 Maggio, 2012, Serum resistin and inflammatory and endothelial activation markers in obese adolescents, J Pediatr, 10.1016/j.jpeds.2012.05.063 Pyrzak, 2010, Adiponectin as a biomarker of the metabolic syndrome in children and adolescents, Eur J Med Res, 15, 147, 10.1186/2047-783X-15-S2-147 Fasshauer, 2008, Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function, Eur J Endorinol, 158, 197, 10.1530/EJE-07-0454 Lin, 2007, Increases in adiponectin predict improved liver, but not peripheral, insulin sensitivity in severely obese women during weight loss, Diabetes, 56, 735, 10.2337/db06-1161 Ballantyne, 2005, Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin, Obes Surg, 15, 692, 10.1381/0960892053923789 Kieffer, 2000, The adipoinsular axis: effects of leptin on pancreatic beta-cells, Am J Physiol Endocrinol Metab, 278, E1, 10.1152/ajpendo.2000.278.1.E1 Ur, 1996, Obesity results as a consequence of glucocorticoid induced leptin resistance, Horm Metab Res, 28, 744, 10.1055/s-2007-979891 Stylianou, 2007, Ghrelin and leptin levels in obese adolescents: relationship with body fat and insulin resistance, Hormones (Athens), 6, 295, 10.14310/horm.2002.1111025 Singh, 2010, Surrogate markers of insulin resistance: a review, World J Diabetes, 1, 36, 10.4239/wjd.v1.i2.36 Bischoff-Ferrari, 2008, Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes, Adv Exp Med Biol, 624, 55, 10.1007/978-0-387-77574-6_5