T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

Michael Kalos1,2, Bruce L. Levine1,2, David L. Porter1,3, Sharyn I. Katz4, Stephan A. Grupp5,6, Adam Bagg1,2, Carl H. June1,2
1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA
2Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
3Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
4Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 USA
5Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA
6Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA

Tóm tắt

Adoptively transferred gene-modified T cells expand in vivo, eliminate leukemic cells, and form functional memory cells in patients.

Từ khóa


Tài liệu tham khảo

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