Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD

Blood - Tập 124 - Trang 2034-2045 - 2014
Ahmad Khoder1, Anushruti Sarvaria2, Abdullah Alsuliman1, Claude Chew2, Takuya Sekine2, Nichola Cooper1, Stephan Mielke3, Hugues de Lavallade1, Muharrem Muftuoglu2, Irina Fernandez Curbelo2, Enli Liu2, Paolo A. Muraro4, Amin Alousi2, Kate Stringaris1, Simrit Parmar2, Nina Shah2, Hila Shaim2, Eric Yvon2, Jeffrey Molldrem2, Rayne Rouce5
1Department of Haematology, Imperial College London, Hammersmith Campus, London, United Kingdom
2Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Centre, Houston, TX
3University of Wuerzburg, Wuerzburg, Germany
4Division of Brain Sciences, Imperial College London, United Kingdom
5Baylor College of Medicine, Houston, TX

Tóm tắt

Key Points

Human IgM memory B cells possess immunoregulatory properties analogous to transitional B cells. IL-10–producing B cells are deficient in cGVHD.


Tài liệu tham khảo

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