Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients

Journal of Neural Transmission - Tập 85 - Trang 19-29 - 1991
R. C. Arora1, H. Y. Meltzer1
1Laboratory of Biological Psychiatry, Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, USA

Tóm tắt

Serotonin2 (5-HT2) receptor binding was studied, using3H-spiperone as the ligand, in post-mortem brain specimens obtained from schizophrenic patients (N=11) and non-psychiatric controls (N=11). The maximum number of binding sites (Bmax) was significantly decreased in schizophrenic patients as compared to normal controls. This difference did not appear to be due to neuroleptic treatment. No difference in Kd (an inverse measure of the affinity of3H-spiperone to its binding sites) was observed between the two groups. However, studies with unmedicated schizophrenic patients are needed to draw any definite conclusion. The role of serotonergic processes in the psychobiology of schizophrenia is discussed.

Tài liệu tham khảo

Burt DR, Creese I, Snyder SH (1976) Binding interactions of lyseric acid diethylamide and related agents with dopamine receptors in the brain. Mol Pharmacol 12: 631–638

Kraepelin E (1919) Lectures of clinical insanity (translated by T Johnstone). William Word and Co, Gryphon Editions Inc, Alabama, pp 357–359

Leysen JE, Niemegeers CJE, van Nueten JM, Laduron PM (1982) [3H]Ketanserin (R 41468), a selective3H-ligand for serotonin2 receptor binding sites. Mol Pharmacol 21: 301–314

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin Phenol reagent. J Biol Chem 193: 265–275

Luabeya MK, Maloteaux J-M, Laduron PM (1984) Regional and cortical laminar distributions of serotonin S2 benzodiazepine, muscarinic, and dopamine D2 receptor in human brain. J Neurochem 43: 1068–1071

Owen F, Crow TJ, Poulter M, Cross AJ, Longden A, Riley GJ (1978) Increased dopaminereceptor sensitivity in schizophrenia. Lancet ii: 223–225

Peroutka SJ, Snyder SH (1979) Multiple serotonin receptors: differential binding on [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Mol Pharmacol 16: 687–699

Scatchard G (1949) The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51: 660–672

Van Nueten JM, Janssen PAJ, Van Beek J, Xhonneux R, Verbeuren TJ, Vanhoutee PM (1981) Vascular effects of ketanserin (R-41468), a novel antagonist of 5-HT2 serotonergic receptors. J Pharmacol Exp Ther 218: 217–230

Weinberger DR, Berman KF, Zec RF (1986) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. 1. Regional cerebral blood flow evidence. Arch Gen Psychiatry 43: 114–124