Hodgkin Lymphoma Across the Age Spectrum: Epidemiology, Therapy, and Late Effects

Seminars in Radiation Oncology - Tập 20 - Trang 30-44 - 2010
Angela Punnett1, Richard W. Tsang2, David C. Hodgson2
1Division of Hematology and Oncology, Hospital for Sick Children, Toronto, ON
2Department of Radiation Oncology, Princess Margaret Hospital, The University of Toronto, Toronto, ON

Tài liệu tham khảo

Brenner, 2008, Ongoing improvement in long-term survival of patients with Hodgkin disease at all ages and recent catch-up of older patients, Blood, 111, 2977, 10.1182/blood-2007-10-115493 Donaldson, 1982, Complications of treatment of Hodgkin's disease in children, Cancer Treat Rep, 66, 977 Mauch, 1983, An evaluation of long-term survival and treatment complications in children with Hodgkin's disease, Cancer, 51, 925, 10.1002/1097-0142(19830301)51:5<925::AID-CNCR2820510527>3.0.CO;2-O Ferme, 2007, Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease, N Engl J Med, 357, 1916, 10.1056/NEJMoa064601 Ries Armstrong, 1998, Epstein–Barr virus and Hodgkin's disease: Further evidence for the three disease hypothesis, Leukemia, 12, 1272, 10.1038/sj.leu.2401097 Andersson, 2006, Epstein–Barr virus and Hodgkin's lymphoma, Herpes, 13, 12 Jarrett, 2002, Viruses and Hodgkin's lymphoma, Ann Oncol, 13, 23, 10.1093/annonc/13.S1.23 Grufferman, 1984, Epidemiology of Hodgkin's disease, Epidemiol Rev, 6, 76, 10.1093/oxfordjournals.epirev.a036276 Spitz, 1986, Ethnic patterns of Hodgkin's disease incidence among children and adolescents in the United States, 1973-82, J Natl Cancer Inst, 76, 235 Cleary, 1994, Hodgkin's disease in the very young, Int J Radiat Oncol Biol Phys, 28, 77, 10.1016/0360-3016(94)90143-0 Parkes, 1994, Hodgkin's disease in children in the West Midlands, 1957-86: A large population-based study, Pediatr Hematol Oncol, 11, 471, 10.3109/08880019409141686 Alexander, 2000, Risk factors for Hodgkin's disease by Epstein–Barr virus (EBV) status: Prior infection by EBV and other agents, Br J Cancer, 82, 1117, 10.1054/bjoc.1999.1049 Glaser, 1997, Epstein–Barr virus-associated Hodgkin's disease: Epidemiologic characteristics in international data, Int J Cancer, 70, 375, 10.1002/(SICI)1097-0215(19970207)70:4<375::AID-IJC1>3.0.CO;2-T Flavell, 2001, South Asian ethnicity and material deprivation increase the risk of Epstein–Barr virus infection in childhood Hodgkin's disease, Br J Cancer, 85, 350, 10.1054/bjoc.2001.1872 Westergaard, 1997, Birth order, sibship size and risk of Hodgkin's disease in children and young adults: A population-based study of 31 million person-years, Int J Cancer, 72, 977, 10.1002/(SICI)1097-0215(19970917)72:6<977::AID-IJC10>3.0.CO;2-2 Chang, 2004, Childhood social environment and Hodgkin's lymphoma: New findings from a population-based case-control study, Cancer Epidemiol Biomarkers Prev, 13, 1361, 10.1158/1055-9965.1361.13.8 Asano, 2009, Age-related Epstein–Barr virus (EBV)-associated B-cell lymphoproliferative disorders: Comparison with EBV-positive classic Hodgkin lymphoma in elderly patients, Blood, 113, 2629, 10.1182/blood-2008-06-164806 Engert, 2005, Hodgkin's lymphoma in elderly patients: A comprehensive retrospective analysis from the German Hodgkin's Study Group, J Clin Oncol, 23, 5052, 10.1200/JCO.2005.11.080 MacMahon, 1966, Epidemiology of Hodgkin's disease, Cancer Res, 26, 1189 Carbone, 2005, AIDS-related lymphomas: From pathogenesis to pathology, Br J Haematol, 130, 662, 10.1111/j.1365-2141.2005.05613.x Bierman, 1996, Hodgkin's disease following solid organ transplantation, Ann Oncol, 7, 265, 10.1093/oxfordjournals.annonc.a010570 Rowlings, 1999, Increased incidence of Hodgkin's disease after allogeneic bone marrow transplantation, J Clin Oncol, 17, 3122, 10.1200/JCO.1999.17.10.3122 Smitten, 2008, A meta-analysis of the incidence of malignancy in adult patients with rheumatoid arthritis, Arthritis Res Ther, 10, R45, 10.1186/ar2404 Landgren, 2006, Autoimmunity and susceptibility to Hodgkin lymphoma: A population-based case-control study in Scandinavia, J Natl Cancer Inst, 98, 1321, 10.1093/jnci/djj361 Goldin, 2004, Familial aggregation of Hodgkin lymphoma and related tumors, Cancer, 100, 1902, 10.1002/cncr.20189 Lister, 1989, Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin's disease: Cotswolds meeting, J Clin Oncol, 7, 1630, 10.1200/JCO.1989.7.11.1630 Ng, 2005, Mid- and post-ABVD gallium scanning predicts for recurrence in early-stage Hodgkin's disease, Int J Radiat Oncol Biol Phys, 61, 175, 10.1016/j.ijrobp.2004.05.019 Wirth, 2002, Fluorine-18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin's disease and non-Hodgkin's lymphoma, Am J Med, 112, 262, 10.1016/S0002-9343(01)01117-2 Van Den Bossche, 2002, 18FDG PET versus high-dose 67Ga scintigraphy for restaging and treatment follow-up of lymphoma patients, Nucl Med Commun, 23, 1079, 10.1097/00006231-200211000-00007 Smith, 2003, Prognostic factors for children with Hodgkin's disease treated with combined-modality therapy, J Clin Oncol, 21, 2026, 10.1200/JCO.2003.07.124 Hasenclever, 1998, A prognostic score for advanced Hodgkin's disease, N Engl J Med, 339, 1506, 10.1056/NEJM199811193392104 Bayle-Weisgerber, 1984, Hodgkin's disease in children, Cancer, 54, 215, 10.1002/1097-0142(19840715)54:2<215::AID-CNCR2820540207>3.0.CO;2-# Gehan, 1990, The intergroup Hodgkin's disease in children, Cancer, 65, 1429, 10.1002/1097-0142(19900315)65:6<1429::AID-CNCR2820650630>3.0.CO;2-B Donaldson, 1976, Pediatric Hodgkin's disease, Cancer, 37, 2436, 10.1002/1097-0142(197605)37:5<2436::AID-CNCR2820370537>3.0.CO;2-# Devita, 1970, Combination chemotherapy in the treatment of advanced Hodgkin's disease, Ann Intern Med, 73, 881, 10.7326/0003-4819-73-6-881 Longo, 1986, Twenty years of MOPP therapy for Hodgkin's disease, J Clin Oncol, 4, 1295, 10.1200/JCO.1986.4.9.1295 Donaldson, 1987, Combined modality treatment with low-dose radiation and MOPP chemotherapy for children with Hodgkin's disease, J Clin Oncol, 5, 742, 10.1200/JCO.1987.5.5.742 Jenkin, 1990, Hodgkin's disease in children: Treatment with MOPP and low-dose, extended field irradiation without laparotomy, Med Pediatr Oncol, 18, 265, 10.1002/mpo.2950180402 Oberlin, 1992, Low-dose radiation therapy and reduced chemotherapy in childhood Hodgkin's disease: The experience of the French Society of Pediatric Oncology, J Clin Oncol, 10, 1602, 10.1200/JCO.1992.10.10.1602 Bonadonna, 1975, Combination chemotherapy of Hodgkin's disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP, Cancer, 36, 252, 10.1002/1097-0142(197507)36:1<252::AID-CNCR2820360128>3.0.CO;2-7 Canellos, 1992, Chemotherapy of advanced Hodgkin's disease with MOPP, ABVD, or MOPP alternating with ABVD, N Engl J Med, 327, 1478, 10.1056/NEJM199211193272102 Duggan, 2003, Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin's disease: Report of an intergroup trial, J Clin Oncol, 21, 607, 10.1200/JCO.2003.12.086 Santoro, 1987, Long-term results of combined chemotherapy-radiotherapy approach in Hodgkin's disease: Superiority of ABVD plus radiotherapy versus MOPP plus radiotherapy, J Clin Oncol, 5, 27, 10.1200/JCO.1987.5.1.27 Engert, 2008, Hodgkin's lymphoma: ESMO clinical recommendations for diagnosis, treatment and follow-up, Ann Oncol, 19, ii65, 10.1093/annonc/mdn092 Press, 2001, Phase III randomized intergroup trial of subtotal lymphoid irradiation versus doxorubicin, vinblastine, and subtotal lymphoid irradiation for stage IA to IIA Hodgkin's disease, J Clin Oncol, 19, 4238, 10.1200/JCO.2001.19.22.4238 Raemaekers, 2002, The achievements of the EORTC Lymphoma Group. European Organisation for Research and Treatment of Cancer, Eur J Cancer, 38, S107, 10.1016/S0959-8049(01)00446-4 Diehl, 2007, Early, intermediate and advanced Hodgkin's lymphoma: Modern treatment strategies, Ann Oncol, 18, ix71, 10.1093/annonc/mdm297 Landman-Parker, 2000, Localized childhood Hodgkin's disease: Response-adapted chemotherapy with etoposide, bleomycin, vinblastine, and prednisone before low-dose radiation therapy-results of the French Society of Pediatric Oncology Study MDH90, J Clin Oncol, 18, 1500, 10.1200/JCO.2000.18.7.1500 Donaldson, 2007, Final results of a prospective clinical trial with VAMP and low-dose involved-field radiation for children with low-risk Hodgkin's disease, J Clin Oncol, 25, 332, 10.1200/JCO.2006.08.4772 Nachman, 2002, Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin's disease who achieve a complete response to chemotherapy, J Clin Oncol, 20, 3765, 10.1200/JCO.2002.12.007 Schellong, 1999, High cure rates and reduced long-term toxicity in pediatric Hodgkin's disease: The German-Austrian multicenter trial DAL-HD-90, J Clin Oncol, 17, 3736, 10.1200/JCO.1999.17.12.3736 Dorffel, 2003, Preliminary results of the multicenter trial GPOH-HD 95 for the treatment of Hodgkin's disease in children and adolescents: Analysis and outlook, Klin Padiatr, 215, 139, 10.1055/s-2003-39372 Engert, 2003, J Clin Oncol, 21, 3601, 10.1200/JCO.2003.03.023 Bonadonna, 2004, ABVD plus subtotal nodal versus involved-field radiotherapy in early-stage Hodgkin's disease: Long-term results, J Clin Oncol, 22, 2835, 10.1200/JCO.2004.12.170 Eich, 2005, Comparison of 30 Gy versus 20 Gy involved field radiotherapy after two versus four cycles of ABVD in early stage Hodgkin's lymphoma: Interim analysis of the German Hodgkin Study Group Trial HD10, Int J Radiat Oncol Biol Phys, 63, S1, 10.1016/j.ijrobp.2005.07.008 Hodgson, 2007, Pediatric Hodgkin lymphoma: Maximizing efficacy and minimizing toxicity, Semin Radiat Oncol, 17, 230, 10.1016/j.semradonc.2007.02.009 Tebbi, 2006, Treatment of stage I, IIA, IIIA(1) pediatric Hodgkin's disease with doxorubicin, bleomycin, vincristine and etoposide (DBVE) and radiation: A Pediatric Oncology Group (POG) study, Pediatr Blood Cancer, 46, 198, 10.1002/pbc.20546 Meyer, 2005, Is there convincing evidence for the use of chemotherapy alone in patients with limited stage Hodgkin's lymphoma?, Eur J Haematol Suppl, 66, 115, 10.1111/j.1600-0609.2005.00464.x Yahalom, 2006, Don't throw out the baby with the bathwater: On optimizing cure and reducing toxicity in Hodgkin's lymphoma, J Clin Oncol, 24, 544, 10.1200/JCO.2005.04.4396 Meyer, 2005, Randomized comparison of ABVD chemotherapy with a strategy that includes radiation therapy in patients with limited-stage Hodgkin's lymphoma: National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group, J Clin Oncol, 23, 4634, 10.1200/JCO.2005.09.085 Thomas, 2007, Results of the EORTC-GELA H9 randomized trials: The H9-F trial (comparing 3 radiation dose levels) and H9-U trial (comparing 3 chemotherapy schemes) in patients with favorable or unfavorable early stage Hodgkin's lymphoma, Haematologica, 92, 27 Noordijk, 2006, Combined-modality therapy for clinical stage I or II Hodgkin's lymphoma: Long-term results of the European Organisation for Research and Treatment of Cancer H7 randomized controlled trials, J Cin Oncol, 24, 3128, 10.1200/JCO.2005.05.2746 Gobbi, 2005, ABVD versus modified stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate- and advanced-stage Hodgkin's lymphoma: Final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi, J Clin Oncol, 23, 9198, 10.1200/JCO.2005.02.907 Aleman, 2003, Involved-field radiotherapy for advanced Hodgkin's lymphoma, N Engl J Med, 348, 2396, 10.1056/NEJMoa022628 Aleman, 2003, Long-term cause-specific mortality of patients treated for Hodgkin's disease, J Clin Oncol, 21, 3431, 10.1200/JCO.2003.07.131 Ferme, 2006, Long-term results and competing risk analysis of the H89 trial in patients with advanced-stage Hodgkin lymphoma: A study by the Groupe d'Etude des Lymphomes de 1'Adulte (GELA), Blood, 107, 4635, 10.1182/blood-2005-11-4429 Diehl, 2003, Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin's disease, N Engl J Med, 348, 2386, 10.1056/NEJMoa022473 Diehl, 2003, Results of the Third Interim Analysis of the HD12 Trial of the GHSG: 8 courses of escalated BEACOPP versus 4 escalated and 4 baseline courses of BEACOPP with or without additive radiotherapy for Advanced Stage Hodgkin's Lymphoma [abstract], Blood, 102, 85 Diehl, 2008, Eight cycles of BEACOPP Escalated compared with 4 cycles of BEACOPP Baseline with or without radiotherapy in patients with advanced stage Hodgkin Lymphoma (HL): Final analysis of the randomized HD12 trial of the German Hodgkin Study Group (GHSG), Blood (ASH Annual Meeting Abstracts), 112, 1558 Ruhl, 2004, The German multinational GPOH-HD95 trial: Treatment results and analysis of failures in pediatric Hodgkins disease using combination chemotherapy with and without radiation, In J Radiat Oncol Biol Phys, 60, S131, 10.1016/j.ijrobp.2004.06.029 Weiner, 1997, Randomized study of intensive MOPP-ABVD with or without low-dose total-nodal radiation therapy in the treatment of stages IIB, IIIA2, IIIB, and IV Hodgkin's disease in pediatric patients: A Pediatric Oncology Group study, J Clin Oncol, 15, 2769, 10.1200/JCO.1997.15.8.2769 Hudson, 2004, Risk-adapted, combined-modality therapy with VAMP/COP and response-based, involved-field radiation for unfavorable pediatric Hodgkin's disease, J Clin Oncol, 22, 4541, 10.1200/JCO.2004.02.139 Cosset, 2001, MOPP/ABV hybrid and irradiation in unfavourable supradiaphragmatic clinical stages I–II Hodgkin's lymphoma: Preliminary results of the EORTC-GELA H8-U randomized trial (# 20931) in 995 patients, Leuk Lymphoma, 42, 12 Diehl, 2004, Reduction of combined modality treatment intensity in early stage Hodgkin's lymphoma: Results of the fourth interim analysis of the HD 10 trial of the GHSG, Eur J Haematol, 73, 37 Horning, 2002, Stanford V and radiotherapy for locally extensive and advanced Hodgkin's disease: Mature results of a prospective clinical trial, J Clin Oncol, 20, 630, 10.1200/JCO.20.3.630 Radford, 2002, ChlVPP/EVA hybrid versus the weekly VAPEC-B regimen for previously untreated Hodgkin's disease, J Clin Oncol, 20, 2988, 10.1200/JCO.2002.11.107 Sieber, 2003, 14-day variant of the bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone regimen in advanced-stage Hodgkin's lymphoma: Results of a pilot study of the German Hodgkin's Lymphoma Study Group, J Clin Oncol, 21, 1734, 10.1200/JCO.2003.06.028 Ferme, 2000, Comparison of chemotherapy to radiotherapy as consolidation of complete or good partial response after six cycles of chemotherapy for patients with advanced Hodgkin's disease: Results of the groupe d'etudes des lymphomes de l'Adulte H89 trial, Blood, 95, 2246 Diehl, 1995, Further chemotherapy versus low-dose involved-field radiotherapy as consolidation of complete remission after six cycles of alternating chemotherapy in patients with advance Hodgkin's disease, Ann Oncol, 6, 901, 10.1093/oxfordjournals.annonc.a059357 Loeffler, 1998, Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin's disease, J Clin Oncol, 16, 818, 10.1200/JCO.1998.16.3.818 Fabian, 1994, Low-dose involved field radiation after chemotherapy in advanced Hodgkin's disease, Ann Intern Med, 120, 903, 10.7326/0003-4819-120-11-199406010-00002 Eich, 2004, The HD12 panel of the German Hodgkin Lymphoma Study Group (GHSG): A quality assurance program based on a multidisciplinary panel reviewing all patients' imaging, Am J Clin Oncol, 27, 279, 10.1097/01.coc.0000092701.47861.81 Schwartz, 2005, Special issues in pediatric Hodgkin's disease, Eur J Haematol Suppl, 66, 55, 10.1111/j.1600-0609.2005.00456.x Dann, 2007, Risk-adapted BEACOPP regimen can reduce the cumulative dose of chemotherapy for standard and high-risk Hodgkin lymphoma with no impairment of outcome, Blood, 109, 905, 10.1182/blood-2006-04-019901 Kelly, 2002, Feasibility of upfront dose-intensive chemotherapy in children with advanced-stage Hodgkin's lymphoma: Preliminary results from the Children's Cancer Group Study CCG-59704, Ann Oncol, 13, 107, 10.1093/annonc/13.S1.107 Advani, 2007, Impact of positive positron emission tomography on prediction of freedom from progression after Stanford V chemotherapy in Hodgkin's disease, J Clin Oncol, 25, 3902, 10.1200/JCO.2007.11.9867 Guay, 2003, Prognostic value of PET using 18F-FDG in Hodgkin's disease for posttreatment evaluation, J Nucl Med, 44, 1225 Naumann, 2001, Prognostic value of positron emission tomography in the evaluation of post-treatment residual mass in patients with Hodgkin's disease and non-Hodgkin's lymphoma, Br J Haematol, 115, 793, 10.1046/j.1365-2141.2001.03147.x de Wit, 2001, 18FDG-PET following treatment as valid predictor for disease-free survival in Hodgkin's lymphoma, Ann Oncol, 12, 29, 10.1023/A:1008357126404 Hutchings, 2006, FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma, Blood, 107, 52, 10.1182/blood-2005-06-2252 Gallamini, 2006, The predictive value of positron emission tomography scanning performed after two courses of standard therapy on treatment outcome in advanced stage Hodgkin's disease, Haematologica, 91, 475 Gallamini, 2007, Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma: A report from a joint Italian-Danish study, J Clin Oncol, 25, 3746, 10.1200/JCO.2007.11.6525 Picardi, 2007, Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans, Leuk Lymphoma, 48, 1721, 10.1080/10428190701559140 Kaplan, 1966, The treatment of Hodgkin's disease, Med Clin North Am, 50, 1591, 10.1016/S0025-7125(16)33107-8 Girinsky, 2006, Involved-node radiotherapy (INRT) in patients with early Hodgkin lymphoma: Concepts and guidelines, Radiother Oncol, 79, 270, 10.1016/j.radonc.2006.05.015 Shahidi, 2006, Site of relapse after chemotherapy alone for stage I and II Hodgkin's disease, Radiother Oncol, 78, 1, 10.1016/j.radonc.2005.10.018 Campbell, 2008, Involved-nodal radiation therapy as a component of combination therapy for limited-stage Hodgkin's lymphoma: A question of field size, J Clin Oncol, 26, 5170, 10.1200/JCO.2007.15.1001 Tirelli, 1990, Hodgkin's disease in patients 70 years of age or more, Cancer Invest, 8, 643, 10.3109/07357909009018934 Klimm, 2007, Hodgkin's lymphoma in the elderly: A different disease in patients over 60, Oncology (Williston Park), 21, 982 Ballova, 2005, A prospectively randomized trial carried out by the German Hodgkin Study Group (GHSG) for elderly patients with advanced Hodgkin's disease comparing BEACOPP baseline and COPP-ABVD (study HD9elderly), Ann Oncol, 16, 124, 10.1093/annonc/mdi023 van Spronsen, 2005, Independent prognostic effect of co-morbidity in lymphoma patients: Results of the population-based Eindhoven Cancer Registry, Eur J Cancer, 41, 1051, 10.1016/j.ejca.2005.01.010 Kolstad, 2007, Standard CHOP-21 as first line therapy for elderly patients with Hodgkin's lymphoma, Leuk Lymphoma, 48, 570, 10.1080/10428190601126610 Coiffier, 2008, The challenges of Hodgkin lymphoma in the elderly, Oncology (Williston Park), 22 Proctor, 2009, Hodgkin lymphoma in the elderly: A clinical review of treatment and outcome, past, present and future, Crit Rev Oncol Hematol, 71, 222, 10.1016/j.critrevonc.2008.12.007 Levis, 2009, Survival after Hodgkin lymphoma: Causes of death and excess mortality in patients treated in 8 consecutive trials, Cancer, 115, 1680, 10.1002/cncr.24178 Favier, 2009, Survival after Hodgkin lymphoma: Causes of death and excess mortality in patients treated in 8 consecutive trials, Cancer, 115, 1680, 10.1002/cncr.24178 Pihkala, 1996, Myocardial function in children and adolescents after therapy with anthracyclines and chest irradiation, Eur J Cancer, 32A, 97, 10.1016/0959-8049(95)00555-2 Polliack, 1995, Late therapy-induced cardiac and pulmonary complications in cured patients with Hodgkin's disease treated with conventional combination chemoradiotherapy, Leuk Lymphoma, 15, 7, 10.3109/10428199509052695 Lipshultz, 1991, Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood, N Engl J Med, 324, 808, 10.1056/NEJM199103213241205 Kremer, 2002, Frequency and risk factors of anthracycline-induced clinical heart failure in children: A systematic review, Ann Oncol, 13, 503, 10.1093/annonc/mdf118 Lipshultz, 1995, Female sex and drug dose as risk factors for late cardiotoxic effects of doxorubicin therapy for childhood cancer, N Engl J Med, 332, 1738, 10.1056/NEJM199506293322602 Donaldson, 2002, VAMP and low-dose, involved-field radiation for children and adolescents with favorable, early-stage Hodgkin's disease: Results of a prospective clinical trial, J Clin Oncol, 20, 3081, 10.1200/JCO.2002.12.101 Hodgson, 2007, Long-term solid cancer risk among 5-year survivors of Hodgkin's lymphoma, J Clin Oncol, 25, 1489, 10.1200/JCO.2006.09.0936 Boice, 2001, Radiation and breast carcinogenesis, Med Pediatr Oncol, 36, 508, 10.1002/mpo.1122 van Leeuwen, 2003, Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease, J Natl Cancer Inst, 95, 971, 10.1093/jnci/95.13.971 Ralleigh, 2004, Breast cancer risk and possible screening strategies for young women following supradiaphragmatic irradiation for Hodgkin's disease, Clin Radiol, 59, 647, 10.1016/j.crad.2004.04.003 2002, Screening for colorectal cancer: Recommendation and rationale, Ann Intern Med, 137, 129, 10.7326/0003-4819-137-2-200207160-00014 Landier, 2007, Children's Oncology Group Long-Term Follow-Up Program Resource Guide, Children's Oncology Group Travis, 2005, Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma, J Natl Cancer Inst, 97, 1428, 10.1093/jnci/dji290 Bhatia, 2003, High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: Report from the Late Effects Study Group, J Clin Oncol, 21, 4386, 10.1200/JCO.2003.11.059 Constine, 1984, Thyroid dysfunction after radiotherapy in children with Hodgkin's disease, Cancer, 53, 878, 10.1002/1097-0142(19840215)53:4<878::AID-CNCR2820530411>3.0.CO;2-J Sklar, 2000, Abnormalities of the thyroid in survivors of Hodgkin's disease: Data from the Childhood Cancer Survivor Study, J Clin Endocrinol Metab, 85, 3227, 10.1210/jc.85.9.3227 de Bruin, 2004, Age-related changes in the ultrastructure of the resting follicle pool in human ovaries, Biol Reprod, 70, 419, 10.1095/biolreprod.103.015784 Ortin, 1990, Gonadal status and reproductive function following treatment for Hodgkin's disease in childhood: The Stanford experience, Int J Radiat Oncol Biol Phys, 19, 873, 10.1016/0360-3016(90)90007-7 van den Berg, 2004, Decreasing the number of MOPP courses reduces gonadal damage in survivors of childhood Hodgkin's disease, Pediatr Blood Cancer, 42, 210, 10.1002/pbc.10422 Bramswig, 1990, The effects of different cumulative doses of chemotherapy on testicular function, Cancer, 65, 1298, 10.1002/1097-0142(19900315)65:6<1298::AID-CNCR2820650607>3.0.CO;2-W Hobbie, 2005, Fertility in males treated for Hodgkin's disease with COPP/ABV hybrid, Pediatr Blood Cancer, 44, 193, 10.1002/pbc.20172 Haukvik, 2006, Treatment-related premature ovarian failure as a long-term complication after Hodgkin's lymphoma, Ann Oncol, 17, 1428, 10.1093/annonc/mdl149 Bonadonna, 1984, Gonadal damage in Hodgkin's disease from cancer chemotherapeutic regimens, Arch Toxicol Suppl, 7, 140, 10.1007/978-3-642-69132-4_16 Behringer, 2005, Secondary amenorrhea after Hodgkin's lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy: A report from the German Hodgkin's Lymphoma Study Group, J Clin Oncol, 23, 7555, 10.1200/JCO.2005.08.138 Brusamolino, 2006, Long-term events in adult patients with clinical stage IA-IIA nonbulky Hodgkin's lymphoma treated with four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine and adjuvant radiotherapy: A single-institution 15-year follow-up, Clin Cancer Res, 12, 6487, 10.1158/1078-0432.CCR-06-1420 Hodgson, 2007, Fertility among female Hodgkin lymphoma survivors attempting pregnancy following ABVD chemotherapy, Hematol Oncol, 25, 11, 10.1002/hon.802