The Treatment of Severe Raynaud's Phenomenon with Verapamil

Journal of Clinical Pharmacology - Tập 22 Số 1 - Trang 74-76 - 1982
Evlin L. Kinney1, Gary G. Nicholas1, Joseph A. Gallo1, CHARLENE PONTORIERO1, Robert Zelis1
1Department of Medicine (Division of Cardiology) and the Department of Surgery, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, Penn.

Tóm tắt

Abstract: Verapamil was evaluated in 16 patients with severe Raynaud's phenomenon. Fifty per cent of patients experienced subjective improvement by history, but only one patient had a substantial reduction in the frequency of Raynaud's phenomenon as assessed by diary analysis. We conclude that verapamil is not effective in most patients with severe Raynaud's phenomenon.

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Tài liệu tham khảo

10.1016/0033-0620(75)90002-X

Braunwald E, 1980, Heart Disease, A Textbook of Cardiovascular Medicine., 1414

10.1002/art.1780230510

Cohen AS, 1971, Preliminary criteria for the classification of systemic lupus erythematosus, Bull Rheum Dis., 21, 643

10.1016/0002-9343(72)90064-2

10.1097/00000441-193202000-00004

10.1016/S0002-8703(39)90279-6

Dabich L, 1972, Digital arteries in patients with scleroderma; an arteriographic and plethysmographic study, Arch Int Med., 130, 708, 10.1001/archinte.1972.03650050036006

Ishikawa H, 1978, Effects of diltiazem hydrochloride (CRD‐401) on hepatic, superior, mesenteric, and femoral hemodynamics, Arzneim-Forsch Drug Res., 28, 400

Vater W, 1976, Effects of nifedipine on the haemodynamics and oxygen consumption of the heart in animal experiments, 33

Schmahl FW, 1964, Die Wirkung von α‐(Isopropyl‐α‐(N‐methyl‐N‐homoveratryl)‐γ‐aminopropyl)‐3,4‐dimethoxyphenyl‐acetonitrile auf die Durchblutung von Myocard, Leber, Niere, Skelettmuskulatur and Gehirn der Katze, Arzneim-Forsch., 14, 1159

Ross G, 1967, Cardiovascular actions of isoveratril, J Pharmacol Exp Therap., 158, 504