Mycoplasma pneumoniae Infection: Role of a Surface Protein in the Attachment Organelle

American Association for the Advancement of Science (AAAS) - Tập 216 Số 4543 - Trang 313-315 - 1982
Ping Hu1, Roger M. Cole2, Yen‐Sung Huang3, Judith A. Graham3, Donald E. Gardner3, Albert M. Collier4, Wallace A. Clyde4
1Northrop Service Inc.-Environmental Science, Research Triangle Park, North Carolina 27709
2National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205
3Health Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711
4Department of Pediatrics, Frank Porter Graham Child Development Center, and Center for Environmental Health and Medical Sciences, University of North Carolina, Chapel Hill 27514

Tóm tắt

Attachment of Mycoplasma pneumoniae to host cells by means of a specialized terminus initiates infection. Monoclonal antibodies to a surface protein (P1) inhibit this process, and react with a region of the tip covered with peplomer-like particles. Since antibodies against the P1 protein are generated by natural and experimental infection and by immunization, the substance may be an important determinant of protective immunity.

Từ khóa


Tài liệu tham khảo

BIBERFELD, G, ULTRASTRUCTURAL FEATURES OF MYCOPLASMA-PNEUMONIAE, JOURNAL OF BACTERIOLOGY 102: 855 (1970).

Cole, R. M., Manual of Methods for General Bacteriology: 34 (1981).

COLLIER, A.M., APPEARANCE OF MYCOPLASMA-PNEUMONIAE IN LUNGS OF EXPERIMENTALLY INFECTED HAMSTERS AND SPUTUM FROM PATIENTS WITH NATURAL DISEASE, AMERICAN REVIEW OF RESPIRATORY DISEASE 110: 765 (1974).

COLLIER, A. M., PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 136: 569 (1971).

COLLIER, A.M., PATHOGENIC MYCOPLASM: 307 (1972).

COMPANS, R.W., ULTRASTRUCTURE ANIMA: 213 (1973).

HU, P.C., IDENTIFICATION OF IMMUNOGENS OF MYCOPLASMA-PNEUMONIAE BY PROTEIN BLOTTING, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 103: 1363 (1981).

HU, P.C., ALTERATIONS IN METABOLISM OF HAMSTER TRACHEAS IN ORGAN-CULTURE AFTER INFECTION BY VIRULENT MYCOPLASMA-PNEUMONIAE, INFECTION AND IMMUNITY 11: 704 (1975).

HU, P.C., INTERACTION OF VIRULENT MYCOPLASMA-PNEUMONIAE WITH HAMSTER TRACHEAL ORGAN-CULTURES, INFECTION AND IMMUNITY 14: 217 (1976).

HU, P.C., SURFACE PARASITISM BY MYCOPLASMA-PNEUMONIAE OF RESPIRATORY EPITHELIUM, JOURNAL OF EXPERIMENTAL MEDICINE 145: 1328 (1977).

HU P.C. unpublished data.

LIPMAN, R. P., PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 131: 1163 (1969).

POWELL, D.A., ATTACHMENT OF MYCOPLASMA-PNEUMONIAE TO RESPIRATORY EPITHELIUM, INFECTION AND IMMUNITY 13: 959 (1976).

TULLY, J.G., PATHOGENIC MYCOPLASMAS - CULTIVATION AND VERTEBRATE PATHOGENICITY OF A NEW SPIROPLASMA, SCIENCE 195: 892 (1977).

WILSON, M.H., ULTRASTRUCTURAL STUDY OF MYCOPLASMA-PNEUMONIAE IN ORGAN-CULTURE, JOURNAL OF BACTERIOLOGY 125: 332 (1976).