Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF‐7 human breast cancer cell

International Journal of Cancer - Tập 102 Số 3 - Trang 250-253 - 2002
Hongbo Hu1, Nam‐Shik Ahn2, Xinlin Yang3, Yong‐Soon Lee2, Kyung‐Sun Kang4
1Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Sumon 441-744, Korea.
2Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Korea.
3College of Life Science and Technology, and Research Center of Materials Science, Beijing Institute of Technology, China
4Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Suwon 441‐744, Korea

Tóm tắt

AbstractAlthough the pharmacology and clinical application of water extracts of Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In the present study, the anti‐tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF‐7 cells. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a dose‐ and time‐dependent manner, which might be mediated through up‐regulation of p21/Waf1 and down‐regulation of cyclin D1. Furthermore, this compound can directly induce apoptosis in MCF‐7 cells, which might be mediated through up‐regulation of a pro‐apoptotic Bax protein and not by the immune system. Our findings suggest that there are multiple mechanisms underlying the anti‐tumor effects of Ganoderma lucidum. © 2002 Wiley‐Liss, Inc.

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Thông tin xuất bản

International Journal of Cancer

Tập 102 Số 3

250-253

Thông tin tác giả