Subchronic toxicity là gì? Các công bố khoa học về Subchronic toxicity

Subchronic toxicity là khả năng gây hại của một chất hoá học được tiếp xúc kéo dài trong một khoảng thời gian ngắn, thường là từ một tháng đến một năm, và áp dụng cho các thí nghiệm trên động vật. Nghiên cứu về subchronic toxicity nhằm đánh giá tác động của chất đó lên cơ thể và các cơ quan nội tạng của động vật trong thời gian kéo dài.
Subchronic toxicity studies are conducted to evaluate the adverse effects of a substance when administered to animals over a period of several weeks to a few months. These studies are conducted to assess potential health hazards and determine the appropriate exposure limits for humans.

During subchronic toxicity studies, animals, typically rodents, are exposed to the substance of interest on a daily basis for a specified duration. The duration of the study can vary depending on the substance being tested and regulatory requirements. The animals are closely monitored for any signs of toxicity and changes in various parameters such as body weight, food and water consumption, clinical signs, organ weights, hematological and biochemical parameters, and histopathological examinations.

The primary objective of subchronic toxicity studies is to provide information on the effects of repeated exposures to the substance and identify target organs or systems that may be susceptible to toxicity. This data helps in determining safe levels of exposure for humans and establishing guidelines for occupational and environmental exposures.

The findings from subchronic toxicity studies can provide valuable insights into potential adverse health effects that may occur with prolonged or repeated exposures to a substance. This information is crucial for assessing the risk associated with the substance and aids in the development of safety guidelines, regulatory standards, and risk management strategies.

It is important to note that subchronic toxicity studies are just one component of the comprehensive toxicological evaluation of a substance. Other types of studies, such as acute toxicity, chronic toxicity, and carcinogenicity studies, may also be conducted to provide a complete profile of the toxicological effects of a substance.

Danh sách công bố khoa học về chủ đề "subchronic toxicity":

The saga of the commons in Kuttanad: appropriations, contests, developments
DECISION - Tập 41 - Trang 217-228 - 2014
Mathew Kuriakose
The paper argues that the mutually enforcing processes of enclosure of land and entanglement of labour have been central to the development of state and capitalism in Kuttanad, a protected Ramsar site in the south Indian state of Kerala. The driving force of epochal changes in Kuttanad was the transformations of the commons; different regimes that ruled Kuttanad have actively engaged in the appropriation, distribution and production of commons along with and for the dominant sections in the region. Reclamation and re-reclamation of backwater lands, spanning over one and half centuries, are thus carried out by the distributive state apparatus in collaboration with its constituent class sections. The resultant shifts in land, crop, labour, technology and resources are what define the crisis of commons in the region.
“Setting the river free”: The removal of the Edwards dam and the restoration of the Kennebec River
Water History - Tập 1 - Trang 131-148 - 2009
Jeff Crane
The Edwards Dam, located on the Kennebec River of Maine, in the state’s capitol city, was removed in 1999 to restore fisheries such as alewives, striped bass, American shad, and endangered short-nosed sturgeon. The dam removal was ordered by the Federal Energy Regulatory Commission for the express purpose of restoring fisheries, the first time ever this was done in American history. This article examines the local environmental advocacy for river and fisheries restoration and the process resulting in dam removal and fisheries restoration. It argues that the Edwards Dam removal was critical in proving the environmental benefits of river restoration through removal as well as some economic benefits. This contributed to other U.S. efforts to remove dams to restore fisheries and assisted the expansion of this stage of American environmentalism. The article uses a number of primary sources including local newspapers, environmental group materials, and a number of interviews collected by the author.
Diversity and distribution of antennal sensilla of lac insect, Kerria chinensis (Hemiptera: Kerridae)
International Journal of Tropical Insect Science - Tập 43 Số 3 - Trang 831-841 - 2023
Chowsong, Himadri, Kalita, Surajit, Das, Purnima, Hazarika, Lakshmi Kanta, Saikia, Priyanka
Sensilla are small hair-like structures modified for the perception of specific stimuli and thereby helping in finding conspecific mates and suitable oviposition sites apart from controlling feeding behavior. The knowledge of type as well as morphology of sensilla helps in understanding their role in the host selection procedure, mate finding and pheromone detection. The scanning electron micrograph revealed the presence of seven different types of sensilla viz., sensilla trichodea 1(ST1); sensilla trichodea 2(ST2) sensilla trichodea 3 (ST3) sensilla basiconica (SB); sensilla chaetica (SCh); sensilla coeloconica (SCo) and sensilla flagellate (SF) on the antenna of K. chinensis. Sensilla trichodea (ST) are slender and flexible hair-shaped sensilla, while SB is thick walled sensilla with sharp-apex, SCh are long, straight, and stiff hair-like structures, SCo are short peg like sensilla with a thin wall, smooth surface, and wider base; and SF are smooth-walled and slender with flexible socket. They are having a floret-like apex with possible apical pores, and are embedded in non-flexible sockets. The study on type and morphology of antennal sensilla of Keria chinensis, the most important and commercially exploited lac insect species revealed significant variations in numbers across the scape, pedicel and flagellum. The numbers of sensilla present on the scape, pedicel and flagellum of the nymphal instars was recorded to be 2.40 ± 0.25, 2.20 ± 0.16 and 13.90 ± 2.07, respectively after 45 days of brood lac inoculation (DAI). The scape, pedicel and flagellum of male stands higher numbers of sensilla (2.60 ± 0.23, 5.50 ± 0.51 and 66.62 ± 3.96, respectively) including sensilla trichoidea (ST1, ST2, ST3), sensilla basiconica (SB), and sensilla flagellum (SF) on the proximal part as against sensilla cheatica (SCh) and sensilla coeloconica (SCo) on the apical flagellomeres. The size of ST1 present on the antenna was found higher (45.30 ± 0.65 μm − 45.90 ± 0.43 μm on length and 0.88 ± 0.39 μm − 0.97 ± 0.02 μm on width) as against 23.60 ± 0.40 μm − 28.10 ± 0.58 μm on length and 0.70 ± 0.07 μm − 0.97 ± 0.02 μm on width in the case of ST3. The length of SB varied from 22.60 ± 0.30 μm and 25.20 ± 0.41 μm as against its width that varied from 0.22 ± 0.02 μm and 0.31 ± 0.03 μm. SF was lacking on the male insects, which found varied from 146.40 ± 0.26 μm − 147.60 ± 0.52 μm in length and 0.82 ± 0.02 μm − 0.97 ± 0.01 μm in width on nymphal instars. Sensilla basiconica was found to be highest on nymphal instars while ST 3 was found to be highest on male lac insect. However SC was found to be least in numbers on the antennae of K. chinensis. Thus, the chemosensilla present on antenna might play a major role in host plant selection as well as the mate finding by K. chinensis.
Quantification of vehicle fleet PM 10 particulate matter emission factors from exhaust and non-exhaust sources using tunnel measurement techniques
Environmental Pollution - Tập 210 - Trang 419-428 - 2016
Samantha Lawrence, Ranjeet Sokhi, Khaiwal Ravindra
Tensor-based mathematical framework and new centralities for temporal multilayer networks
Information Sciences - Tập 512 - Trang 563-580 - 2020
Dingjie Wang, Wei Yu, Xiufen Zou
PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial
Lancet Oncology, The - Tập 8 - Trang 797-805 - 2007
Florian Lordick, Katja Ott, Bernd-Joachim Krause, Wolfgang A Weber, Karen Becker, Hubert J Stein, Sylvie Lorenzen, Tibor Schuster, Hinrich Wieder, Ken Herrmann, Rainer Bredenkamp, Heinz Höfler, Ulrich Fink, Christian Peschel, Markus Schwaiger, Jörg R Siewert
Evaluation of soil-erosion and pesticide-exposure control strategies
Journal of Environmental Economics and Management - Tập 9 - Trang 279-288 - 1982
Ralph E Heimlich, Clayton W Ogg
Size Selection by Zebra Mussels (Dreissena polymoropha) Exposed to Microplastic Fibers
Water, Air, and Soil Pollution - Tập 234 - Trang 1-12 - 2023
Robert S. Stelzer, Jackie A. Behrens, Sarah Pascarella, A. J. Paea, Jessica R. Lucas
Plastic production is increasing rapidly at a global scale and microplastics are widely distributed in aquatic ecosystems and food webs. As filter feeders, bivalves present entry points for microplastics into food webs and numerous descriptive and experimental studies have addressed microplastic size selection by bivalves. However, much less is known about size selection of microplastic fibers by bivalves. This represents a gap in understanding of how microplastics impact bivalves and food webs, particularly given the numerical dominance of microplastic fibers in freshwater and marine ecosystems and in bivalve tissue. To address this gap, we tested two hypotheses: (1) the net accumulation of polyester fibers in zebra mussels (Dreissena polymoropha) is dependent on fiber size and (2) zebra mussel size impacts the amount of plastic fibers accumulated. We conducted two experiments to test these hypotheses. In the first experiment, we exposed zebra mussels to pink polyester fibers (PPF) of four different lengths (0.25–2.0 mm), offered separately. In the second experiment, we exposed mussels with PPF of three different lengths (0.25–1.0 mm) in a mixture. Both hypotheses were supported. In each experiment, PPF of the smallest size (0.25 mm) disproportionately accumulated in the mussels. In addition, PPF accumulation of 0.25 and 0.50 mm PPF increased as zebra mussel shell length increased. Our results have implications for how microplastic fibers in water columns may impact bivalves and their food webs and demonstrate that size distribution should be considered when sampling bivalves for microplastics in ecosystems.
Allergen-Immuntherapie auch in Real-World-Studie wirksam
HNO Nachrichten - Tập 52 - Trang 63-63 - 2022
Redaktion Facharztmagazine
Classe of functions defined by transducers
Cybernetics and Systems Analysis - Tập 26 - Trang 781-788 - 1990
L. P. Lisovik
Tổng số: 3,954,603   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 395461