Testing structural models of psychopathology at the genomic levelWorld Psychiatry - Tập 19 Số 3 - Trang 350-359 - 2020
Irwin D. Waldman, Holly E. Poore, Justin M. Luningham, Jingjing Yang
Genome‐wide association studies (GWAS) have revealed hundreds of genetic loci associated with the vulnerability to major psychiatric disorders, and post‐GWAS analyses have shown substantial genetic correlations among these disorders. This evidence supports the existence of a higher‐order structure of psychopathology at both the genetic and phenotypic levels. Despite recent efforts by colla...... hiện toàn bộ
Intergenerational transmission of trauma effects: putative role of epigenetic mechanismsWorld Psychiatry - Tập 17 Số 3 - Trang 243-257 - 2018
Rachel Yehuda, Amy Lehrner
This paper reviews the research evidence concerning the intergenerational transmission of trauma effects and the possible role of epigenetic mechanisms in this transmission. Two broad categories of epigenetically mediated effects are highlighted. The first involves developmentally programmed effects. These can result from the influence of the offspring's early environmental exposures, incl...... hiện toàn bộ
Diagnosis and classification of disorders specifically associated with stress: proposals for ICD-11World Psychiatry - Tập 12 Số 3 - Trang 198-206 - 2013
And re as Maercker, Chris R. Brewin, Richard A. Bryant, Marylène Cloître, Mark van Ommeren, Lynne Jones, Asma Humayan, Ashraf Kagee, Augusto E. Llosa, Cécile Rousseau, Daya Somasundaram, R. R. de Souza, Yuriko Suzuki, Inka Weissbecker, Simon Wessely, Michael B. First, Geoffrey M. Reed
Population‐based analysis of health care contacts among suicide decedents: identifying opportunities for more targeted suicide prevention strategiesWorld Psychiatry - Tập 15 Số 2 - Trang 135-145 - 2016
Ayal Schaffer, Mark Sinyor, Paul Kurdyak, Simone N. Vigod, Jitender Sareen, Catherine Reis, Diane Green, James M. Bolton, Anne E. Rhodes, Sophie Grigoriadis, John Cairney, Amy Cheung
The objective of this study was to detail the nature and correlates of mental health and non‐mental health care contacts prior to suicide death. We conducted a systematic extraction of data from records at the Office of the Chief Coroner of Ontario of each person who died by suicide in the city of Toronto from 1998 to 2011. Data on 2,835 suicide deaths were linked with provincial health ad...... hiện toàn bộ