Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic responseWiley - Tập 38 - Trang 1-12 - 2018
Feifei Zhang, Wenjie Wang, Yuan Long, Hui Liu, Jijun Cheng, Lin Guo, Rongyu Li, Chao Meng, Shan Yu, Qingchuan Zhao, Shun Lu, Lili Wang, Haitao Wang, Danyi Wen
Patient-derived organoids and xenografts (PDXs) have emerged as powerful models in functional diagnostics with high predictive power for anticancer drug response. However, limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy, and inability to subject to systemic drug administration for ex vivo organoid culture hinder...... hiện toàn bộ
Primary intrathoracic liposarcoma: a clinical analysis of 31 casesWiley - Tập 39 - Trang 1-3 - 2019
Zhixue Fu, Kun Yang, Xu Yang, Shulan Chen, Wenqing Wang, Dongfu Chen, Jun Zhao, Zhishan Li, Qinfu Feng, Zongmei Zhou, Luhua Wang, Shugeng Gao, Jun Liang
Các đặc điểm chuyển hóa của tế bào ung thư Dịch bởi AI Wiley - Tập 38 - Trang 1-6 - 2018
Yugang Wang, Yan Xia, Zhimin Lu
Tế bào ung thư độc đáo tái lập trình các hoạt động tế bào của chúng để hỗ trợ sự tăng sinh và di chuyển nhanh chóng, cũng như để chống lại căng thẳng chuyển hóa và gen độc trong quá trình tiến triển của ung thư. Trong quá trình tái lập trình này, chuyển hóa của tế bào ung thư và các hoạt động tế bào khác được tích hợp và điều chỉnh lẫn nhau, và tế bào ung thư điều chỉnh các enzyme chuyển hóa theo ...... hiện toàn bộ
#chuyển hóa tế bào ung thư #enzyme #chức năng phi điển hình #căng thẳng chuyển hóa #sửa chữa DNA
Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer DatabaseWiley - Tập 39 - Trang 1-9 - 2019
Gary D. Lewis, Yan Xing, Waqar Haque, Tejal Patel, Mary Schwartz, Albert Chen, Andrew Farach, Sandra S. Hatch, E. Brian Butler, Jenny Chang, Bin S. Teh
Invasive micropapillary carcinoma (IMPC) is an uncommon subtype of breast cancer. Previous studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carcinoma (IDC). The purpose of the present study was to determine the clinical characteristics, outcomes, and propensity for lymph node metastasis of patients with IMPC of the breast recorded ...... hiện toàn bộ
Tumor vasculature: a sally port for inhibiting cancer cell spreadingWiley - Tập 38 - Trang 1-3 - 2018
Chao-Nan Qian, Francesco Pezzella
The close relationship between metastasis and establishment of tumor vasculature has inspired enormous research interests aiming to suppress metastasis via inhibiting the development of tumor vasculature. International experts gathered in Guangzhou, China on May 10–12, 2018 in The 4th International Meeting of Cancer and Blood Vessels to discuss the multiple ways for solid tumors to establish their...... hiện toàn bộ
CMAB009 plus irinotecan versus irinotecan-only as second-line treatment after fluoropyrimidine and oxaliplatin failure in KRAS wild-type metastatic colorectal cancer patients: promising findings from a prospective, open-label, randomized, phase III trialWiley - Tập 39 - Trang 1-13 - 2019
Yuankai Shi, Jin Li, Jianming Xu, Yan Sun, Liwei Wang, Ying Cheng, Wei Liu, Guoping Sun, Yigui Chen, Li Bai, Yiping Zhang, Xiaohui He, Yi Luo, Zhehai Wang, Yunpeng Liu, Qiang Yao, Yuhong Li, Shukui Qin, Xiaohua Hu, Feng Bi, Rongsheng Zheng, Xuenong Ouyang
The 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) regimen is the standard first-line treatment for metastatic colorectal cancer (mCRC), however, the optimal second-line regimen for KRAS wild-type mCRC patients is still investigational. In this study, we aimed to determine the clinical efficacy and safety of CMAB009 plus irinotecan compared to irinotecan-only as a second-line regimen for trea...... hiện toàn bộ
Precision medicine becomes reality—tumor type-agnostic therapyWiley - Tập 38 - Trang 1-7 - 2018
Li Yan, Wei Zhang
Precision medicine just witnessed two breakthroughs in oncology in 2017. Pembrolizumab (Keytruda), Merck’s anti-programmed cell death-1 (PD-1) monoclonal antibody (mAb), received accelerated approval in May 2017 by the US Food and Drug Administration for the treatment of adult and pediatric patients with unresectable or metastatic solid tumors that have been identified as having microsatellite ins...... hiện toàn bộ
Boron delivery agents for neutron capture therapy of cancerWiley - Tập 38 - Trang 1-15 - 2018
Rolf F. Barth, Peng Mi, Weilian Yang
Boron neutron capture therapy (BNCT) is a binary radiotherapeutic modality based on the nuclear capture and fission reactions that occur when the stable isotope, boron-10, is irradiated with neutrons to produce high energy alpha particles. This review will focus on tumor-targeting boron delivery agents that are an essential component of this binary system. Two low molecular weight boron-containing...... hiện toàn bộ
Post-translational modification of Parkin and its research progress in cancerWiley - Tập 39 - Trang 1-10 - 2019
Dan Ding, Xiang Ao, Ying Liu, Yuan-Yong Wang, Hong-Ge Fa, Meng-Yu Wang, Yu-Qi He, Jian-Xun Wang
Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkinsonism (AR-JP) via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene, which itself belongs to an E3 ubiquitin ligase. Since the discovery of the Parkin gene in the late 1990s, researchers in many countries have begun extensive research on t...... hiện toàn bộ