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CMAB009 plus irinotecan versus irinotecan-only as second-line treatment after fluoropyrimidine and oxaliplatin failure in KRAS wild-type metastatic colorectal cancer patients: promising findings from a prospective, open-label, randomized, phase III trial
Wiley - Tập 39 - Trang 1-13 - 2019
Yuankai Shi, Jin Li, Jianming Xu, Yan Sun, Liwei Wang, Ying Cheng, Wei Liu, Guoping Sun, Yigui Chen, Li Bai, Yiping Zhang, Xiaohui He, Yi Luo, Zhehai Wang, Yunpeng Liu, Qiang Yao, Yuhong Li, Shukui Qin, Xiaohua Hu, Feng Bi, Rongsheng Zheng, Xuenong Ouyang
The 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) regimen is the standard first-line treatment for metastatic colorectal cancer (mCRC), however, the optimal second-line regimen for KRAS wild-type mCRC patients is still investigational. In this study, we aimed to determine the clinical efficacy and safety of CMAB009 plus irinotecan compared to irinotecan-only as a second-line regimen for trea...... hiện toàn bộ
Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response
Wiley - Tập 38 - Trang 1-12 - 2018
Feifei Zhang, Wenjie Wang, Yuan Long, Hui Liu, Jijun Cheng, Lin Guo, Rongyu Li, Chao Meng, Shan Yu, Qingchuan Zhao, Shun Lu, Lili Wang, Haitao Wang, Danyi Wen
Patient-derived organoids and xenografts (PDXs) have emerged as powerful models in functional diagnostics with high predictive power for anticancer drug response. However, limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy, and inability to subject to systemic drug administration for ex vivo organoid culture hinder...... hiện toàn bộ
A modified clinicopathological tumor staging system for survival prediction of patients with penile cancer
Wiley - Tập 38 - Trang 1-10 - 2018
Zai-Shang Li, Antonio Augusto Ornellas, Christian Schwentner, Xiang Li, Alcides Chaux, Georges Netto, Arthur L. Burnett, Yong Tang, JiunHung Geng, Kai Yao, Xiao-Feng Chen, Bin Wang, Hong Liao, Nan Liu, Peng Chen, Yong-Hong Lei, Qi-Wu Mi, Hui-Lan Rao, Ying-Ming Xiao, Qi-Lin Wang, Zi-Ke Qin, Zhuo-Wei Liu, Yong-Hong Li, Zi-Jun Zou, Jun-Hang Luo, Hui Li, Hui Han, Fang-Jian Zhou
The 8th American Joint Committee on Cancer tumor–node–metastasis (AJCC-TNM) staging system is based on a few retrospective single-center studies. We aimed to test the prognostic validity of the staging system and to determine whether a modified clinicopathological tumor staging system that includes lymphovascular embolization could increase the accuracy of prognostic prediction for patients with s...... hiện toàn bộ
Primary intrathoracic liposarcoma: a clinical analysis of 31 cases
Wiley - Tập 39 - Trang 1-3 - 2019
Zhixue Fu, Kun Yang, Xu Yang, Shulan Chen, Wenqing Wang, Dongfu Chen, Jun Zhao, Zhishan Li, Qinfu Feng, Zongmei Zhou, Luhua Wang, Shugeng Gao, Jun Liang
Bortezomib inhibits growth and sensitizes glioma to temozolomide (TMZ) via down-regulating the FOXM1–Survivin axis
Wiley - Tập 39 - Trang 1-16 - 2019
Jun-Hai Tang, Lin Yang, Ju-Xiang Chen, Qing-Rui Li, Li-Rong Zhu, Qing-Fu Xu, Guo-Hao Huang, Zuo-Xin Zhang, Yan Xiang, Lei Du, Zheng Zhou, Sheng-Qing Lv
High-grade glioma (HGG) is a fatal human cancer. Bortezomib, a proteasome inhibitor, has been approved for the treatment of multiple myeloma but its use in glioma awaits further investigation. This study aimed to explore the chemotherapeutic effect and the underlying mechanism of bortezomib on gliomas. U251 and U87 cell viability and proliferation were detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-...... hiện toàn bộ
Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
Wiley - Tập 39 - Trang 1-9 - 2019
Tong Wu, Xuan Wu, Hong-Yang Wang, Lei Chen
Tumor immune microenvironment is closely related to tumor initiation, prognosis, and response to immunotherapy. The immune landscapes, number of infiltrating immune cells, and the localization of lymphocytes in the tumor vary in across different types of tumors. The immune contexture in cancer, which is determined by the density, composition, functional state and organization of the leukocyte infi...... hiện toàn bộ
Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy
Wiley - Tập 38 - Trang 1-11 - 2018
Fuh Yong Wong, Wei Ying Tham, Wen Long Nei, Cindy Lim, Hui Miao
Asians are diagnosed with breast cancer at a younger age than Caucasians are. We studied the effect of age on locoregional recurrence and the survival of Asian breast cancer patients treated with breast-conserving therapy. Medical records of 2492 patients treated with breast-conserving therapy between 1989 and 2012 were reviewed. The Kaplan–Meier method was used to estimate locoregional recurrence...... hiện toàn bộ
Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining
Wiley - Tập 38 - Trang 1-22 - 2018
Minjie Zhang, Liu Wang, Ke An, Jun Cai, Guochao Li, Caiyun Yang, Huixian Liu, Fengxia Du, Xiao Han, Zilong Zhang, Zitong Zhao, Duanqing Pei, Yuan Long, Xin Xie, Qi Zhou, Yingli Sun
Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) share many common features, including similar morphology, gene expression and in vitro differentiation profiles. However, genomic stability is much lower in iPSCs than in ESCs. In the current study, we examined whether changes in DNA damage repair in iPSCs are responsible for their greater tendency towards mutagenesis. Mouse iP...... hiện toàn bộ
Application of erector spinae plane block guided by ultrasound for postoperative analgesia in breast cancer surgery: A randomized controlled trial
Wiley - Tập 40 Số 2-3 - Trang 122-125 - 2020
Wensheng He, Zhenyu Wu, Lingjie Zu, Hai-Jun Sun, Xiaochun Yang
Disrupting redox stabilizer: a novel therapeutic strategy for colorectal cancer
Wiley - Tập 39 - Trang 1-3 - 2019
Dunyaporn Trachootham, Watcharapol Khoonin
Tổng số: 113   
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