Morphine depresses the twitch and tetanus of stimulated guinea‐pig ileum by reducing acetylcholine released from cholinergic nerve endings. Acetylcholine output per shock falls to roughly the same residual amount at varying stimulation rates. Since normal output per shock declines with increasing stimulus frequency, the proportionate effect of morphine diminishes as stimulus frequency rise...... hiện toàn bộ
Experiments on nerves in situ and on isolated nerves provide no evidence that morphine interferes with impulse transmission in myelinated or nonmyelinated nerve fibres. The concentrations used in experiments on isolated nerves were 10‐ to 100‐times as high as those required to depress transmission a autonomic nerve‐effector cell junctions. Examination of the rest...... hiện toàn bộ
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