THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUM

Wiley - Tập 12 Số 1 - Trang 119-127 - 1957
W. D. M. Paton1
1Department of Pharmacology, Royal College of Surgeons of England, London

Tóm tắt

Morphine depresses the twitch and tetanus of stimulated guinea‐pig ileum by reducing acetylcholine released from cholinergic nerve endings. Acetylcholine output per shock falls to roughly the same residual amount at varying stimulation rates. Since normal output per shock declines with increasing stimulus frequency, the proportionate effect of morphine diminishes as stimulus frequency rises. Acute “tolerance” to morphine and a state of “morphine‐dependence” can be produced. Phenadoxone, dihydromorphinone, metopon, methadone, and heroin are more active, codeine and pethidine less active, than morphine. Nalorphine also depresses the twitch and can desensitize the gut both to itself and to morphine.

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Tài liệu tham khảo

10.1111/j.1476-5381.1952.tb00720.x

10.1113/jphysiol.1951.sp004639

Feldberg W., 1954, Ibid, 124, 219

10.1111/j.1476-5381.1954.tb00848.x

10.1038/163720a0

Kosterlitz H., 1955, J. Physiol, 129, 18P

Paton W. D. M., 1955, Ibid, 127, 40P

Paton W. D. M.(1956).Abstr. 20th int. physiol. Congr. Bruxelles 708.

Robertson P. A., 1953, J. Physiol, 121, 54P

10.1111/j.1476-5381.1953.tb01333.x

10.1007/BF00245442

10.1111/j.1476-5381.1955.tb00105.x

Williams Vaughan E. M., 1950, Ibid, 5, 584

Williams Vaughan E. M., 1951, Ibid, 6, 263

Thông tin
Thông tin xuất bản

Wiley

Tập 12 Số 1

119-127

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