Wiley

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Rapid Glucocorticoid Mediation of Suppressed Testosterone Biosynthesis in Male Mice Subjected to Immobilization Stress
Wiley - Tập 25 Số 6 - Trang 973-981 - 2004
Qiang Dong, Antonio Salva, Chantal M. Sottas, En-Mei Niu, Michael Holmes, Matthew P. Hardy
ABSTRACT: Physical and psychosocial stress challenge homeostasis, increasing glucocorticoid secretion (in rodents, corticosterone [CORT]) while decreasing testosterone (T) levels. The dynamics of stress‐induced changes in T, CORT, and luteinizing hormone (LH) concentrations in mice have not been investigated previously. In particular, it remains to be established wh...... hiện toàn bộ
Transgenerational Effect of the Endocrine Disruptor Vinclozolin on Male Spermatogenesis
Wiley - Tập 27 Số 6 - Trang 868-879 - 2006
Matthew D. Anway, Mushtaq A. Memon, Mehmet Uzumcu, Michael K. Skinner
ABSTRACT: The current study was designed to examine the actions of a model endocrine disruptor on embryonic testis development and male fertility. Pregnant rats (F0) that received a transient embryonic exposure to an environmental endocrine disruptor, vinclozolin, had male offspring (F1) with reduced spermatogenic capacity. The reduced spermatogenetic capacity obser...... hiện toàn bộ
p53 and Fas Are Sequential Mechanisms of Testicular Germ Cell Apoptosis
Wiley - Tập 23 Số 1 - Trang 64-70 - 2002
Yizhong Yin, Brandon C. Stahl, William C. DeWolf, Abraham Morgentaler
Testicular germ cell apoptosis in the cryptorchid testis is induced by abdominal heat stress. p53‐dependent apoptosis appears responsible for the initial phase of germ cell loss in experimental cryptorchidism based on a 3‐day delay of apoptosis in p53−1− mice. However, the mechanisms underlying the subsequent p53‐in...... hiện toàn bộ
Managing the Risks of Prostate Disease During Testosterone Replacement Therapy in Older Men: Recommendations for a Standardized Monitoring Plan
Wiley - Tập 24 Số 3 - Trang 299-311 - 2003
Shalender Bhasin, Atam B. Singh, R. P. Mac, Ballentine Carter, Martin I. Lee, Glenn R. Cunningham
Normal and Abnormal Development of the Male Urogenital Tract
Wiley - Tập 13 Số 6 - Trang 465-475 - 1992
Gerald R. Cunha, Elaine T. Alarid, Timothy Turner, Annemarie A. Donjacour, Eugenie L. Boutin, Barbara A. Foster
ABSTRACT: Androgen‐dependent male urogenital development occurs via mesenchymal‐epithelial interactions in which mesenchyme induces epithelial morphogenesis, regulates epithelial proliferation, and evokes expression of tissue‐specific secretory proteins. Mesenchymal‐epithelial interactions continue to be important into adulthood. For example, mesenchyme of the uroge...... hiện toàn bộ
The Action of Calcitonin on the TM4 Sertoli Cell Line and on Rat Sertoli Cell‐Enriched Cultures
Wiley - Tập 10 Số 4 - Trang 321-331 - 1989
Atif M. Nakhla, Jennie P. Mather, Olli A. Jänne, C. Wayne Bardin
The effects of synthetic salmon calcitonin on primary Sertoli cell‐enriched cultures and on an established cell line (TM4 cells, derived from immature mouse Sertoli cells) were studied. Synthetic salmon calcitonin stimulated the conversion of [3H]adenine to [3H]cyclic AMP in both cell systems. In addition, this peptide stimulat...... hiện toàn bộ
Human Glyceraldehyde 3‐Phosphate Dehydrogenase‐2 Gene Is Expressed Specifically in Spermatogenic Cells
Wiley - Tập 21 Số 2 - Trang 328-338 - 2000
Janet L. Welch, Paula R. Brown, Deborah A. O’Brien, Patricia L. Magyar, Donna O. Bunch, Chisato Mori, Edward M. Eddy
ABSTRACT: Although the process of glycolysis is highly conserved in eukaryotes, several glycolytic enzymes have unique structural or functional features in spermatogenic cells. We previously identified and characterized the mouse complementary DNA (cDNA) and a gene for 1 of these enzymes, glyceraldehyde 3‐phosphate dehydrogenase‐s (Gapds)....... hiện toàn bộ
Significance of Reactive Oxygen Species and Antioxidants in Defining the Efficacy of Sperm Preparation Techniques
Wiley - Tập 9 Số 6 - Trang 367-376 - 1988
R. John Aitken, J. S. Clarkson
The mechanisms responsible for mediating the influence of sperm preparation protocols on human sperm function have been investigated. Techniques that involved the separation of motile spermatozoa prior to centrifugation were found to yield sperm suspensions of highest quality. If the spermatozoa were centrifuged prior to isolation of the motile cells, sperm function was impaired. The detri...... hiện toàn bộ
Varicocele and Fertility: Relationship Between Testicular Volume and Seminal Parameters Before and After Treatment
Wiley - Tập 27 Số 4 - Trang 548-551 - 2006
Alessandro Zucchi, Luigi Mearini, Ettore Mearini, Fabrizio Fioretti, Vittorio Bini, Massimo Porena
ABSTRACT: Varicocele is a condition of varicosity and tortuosity of the pampiniform plexus that is often associated with a reduction in the volume of the affected testicle. Today there is much debate about how much the varicocele actually damages the reproductive system and the mechanism through which this occurs. Furthermore, it has not yet clearly been established...... hiện toàn bộ
Hypoxia‐Inducible Factor‐1α Is Constitutively Expressed in Murine Leydig Cells and Regulates 3β‐Hydroxysteroid Dehydrogenase Type 1 Promoter Activity
Wiley - Tập 30 Số 2 - Trang 146-156 - 2009
Jeffrey J. Lysiak, Jennifer L. Kirby, Jacques Tremblay, Robin I. Woodson, Michael A. Reardon, Lisa A. Palmer, Terry T. Turner
ABSTRACT: Hypoxia‐inducible factor‐1α (HIF‐1α) is a transcription factor that plays an essential role in oxygen homeostasis. HIF‐1α is constitutively made in cells; however, it is ubiquitinated and degraded under normoxic conditions. Hypoxia prevents the ubiquitination of HIF‐1α, resulting in stabilization of the protein and activation of target genes. Because of it...... hiện toàn bộ
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