Wiley
0192-253X
1520-6408
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Các bài báo tiêu biểu
Rapid induction and clearance of TGFβ1 is an early response to wounding in the mouse embryo
Tập 14 Số 3 - Trang 225-238 - 1993
AbstractThe TGFβ family of growth factors has been implicated as playing a
significant role in many aspects of embryonic morphogenesis, and also as a
mediator of adult tissue repair processes. Unlike the situation in the adult,
rissue repair in the embryo does not result in scarring, and it has been
suggested that this might be due, in part, to reduced levels of growth factors,
particularly TGFβ, ...
Mutations affecting embryonic cell migrations in Caenorhabditis elegans
Tập 11 Số 1 - Trang 49-64 - 1990
AbstractFour recessive mutations that affect long‐range embryonic migration of
the two canal‐associated neurons (CANs) in C. elegans were isolated and
characterized with the goal of identifying genes involved in control of directed
cell movement. Mutant animals were identified initially by their “withered”
tails, a phenotype associated with abnormal CAN migration; the mutants were then
analyzed fo...
S6 phosphorylation results from prothoracicotropic hormone stimulation of insect prothoracic glands: A role for S6 kinase
Tập 15 Số 4 - Trang 332-338 - 1994
AbstractThe insect prothoracic glands are the source of steroidal molting
hormone precursors and the glands are stimulated by a brain neuropeptide,
prothoracicotropic hormone (PTTH). Previous work from this laboratory revealed
that PTTH acts via a cascade including Ca2+/calmodulin activation of adenylate
cyclase, protein kinase A, and the subsequent phosphorylation of a 34 kDa
protein (p34) hypoth...
Use of a yeast site‐specific recombinase to generate embryonic mosaics in Drosophila
Tập 13 Số 5 - Trang 367-375 - 1992
AbstractAn efficient method for generating embryonic mosaics using a yeast
site‐specific recombinase (FLP), under the control of a heat shock promoter, is
described. FLP‐recombinase can promote mitotic exchange between homologous
chromosomes that contain FRT (FLP Recombination Target) sequences. To
demonstrate the efficiency of FLP‐recombinase to generate embryonic mosaics,
clones of the recessive...
Tissue‐specific and developmental expression of human transthyretin gene in transgenic mice
Tập 8 Số 4 - Trang 195-205 - 1987
AbstractTo analyze the regulation of transthyretin gene expression we have
produced transgenic mice by microinjecting cloned human transthyretin genes into
fertilized eggs of C57BL/6 mice. The 7.6‐kilobase (kb) human transthyretin gene
containing about 500 base pairs (bp) in the upstream region was used for
microinjection. Seven out of nine transgenic mice had detectable amounts of
human transthyr...
Liver‐specific and high‐level expression of human serum amyloid P component gene in transgenic mice
Tập 10 Số 5 - Trang 365-371 - 1989
AbstractTo analyze the regulation of human serum amyloid P component (SAP) gene
expression, we have produced seven transgenic mice. The 3.3 kb human SAP genes
containing about 0.8 kb of 5′ and 1.5 kb of 3′ flanking region were injected
into fertilized eggs of C57BL/6 mice. In five of the seven transgenic mice,
human SAP was detected in the sera and serum concentrations were higher than
that of hum...
Sequence analysis of translationally controlled maternal mRNAs from Urechis caupo
Tập 14 Số 6 - Trang 485-491 - 1993
AbstractFertilization of Urechis coupo oocytes stimulates dramatic changes in
the pattern of protein synthesis. This shift is brought about entirely through
selective translation of the large pool of maternal mRNAs synthesized and stored
during oogenesis. My laboratory has identified cDNA clones to more than 20
different Urechis maternal mRNAs. These have been used to determine whether the
complem...
Drosophila salivary gland proteins and pupation
Tập 3 Số 3 - Trang 255-272 - 1982
AbstractPulse‐labeling experiments of salivary glands from the prepupal stages
of development showed selectively high rates of synthesis of a set of low
molecular weight proteins (6K–12K). These proteins are stably maintained in the
salivary glands during prepupal development and are subsequently transported to
the pupation fluid (found between the pupal case and the prepupal cuticle) when
pupatio...
Temporal control of urate oxidase activity during development of the third‐instar larva of Drosophila: The role of 20‐hydroxyecdysone
Tập 3 Số 3 - Trang 215-233 - 1982
AbstractThe tissue‐specific enzyme urate oxidase is confined exclusively to the
Malpighian tubules of Drosophila melanogaster and expressed only in the
third‐instar larva and the adult. Shortly before pupariation urate oxidase
activity declines precipitously and is not detectable 24 hours later. That
20‐hydroxyecdysone is the factor that triggers the disappearance of urate
oxidase activity in late...