Wiley
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Sắp xếp:
Molecular mechanisms of cartilage destruction: Mechanics, inflammatory mediators, and aging collide
Wiley - Tập 54 Số 5 - Trang 1357-1360 - 2006
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
Wiley - Tập 56 Số 7 - Trang 2202-2210 - 2007
AbstractObjectiveTo determine whether genetic variants of the interferon
regulatory factor 5 (IRF‐5) and Tyk‐2 genes are associated with rheumatoid
arthritis (RA).MethodsFive single‐nucleotide polymorphisms (SNPs) in IRF5 and 3
SNPs in Tyk2 were analyzed in a Swedish cohort of 1,530 patients with RA and 881
controls. A replication study was performed in a Dutch cohort of 387 patients
with RA and 1...
The effect of low oxygen concentration on growth, glycolysis, and sulfate incorporation by articular chondrocytes in monolayer culture
Wiley - Tập 16 Số 5 - Trang 646-656 - 1973
AbstractRadiosulfate incorporation, DNA synthesis, and glycoiysis by rabbit
articular chondrocytes and skin fibrocytes in monolayer culture were compared
under different concentrations of oxygen (19, 6.8, 1.3, and 0.6%). Cell for
cell, chondrocytes under each condition had higher levels of radiosulfate
incorporation and glycolysis than did fibrocytes. Growth of the fibrocytes was
reduced approxima...
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin‐1 and oncostatin M: A time‐course study using real‐time quantitative reverse transcription–polymerase chain reaction
Wiley - Tập 46 Số 4 - Trang 961-967 - 2002
AbstractObjectivePrevious studies have reported elevated levels of interleukin‐1
(IL‐1) and oncostatin M (OSM) in rheumatoid joints, as well as the synergistic
degradation of human articular cartilage by this cytokine combination. The
present study was undertaken to investigate the ability of IL‐1 and OSM to
modulate gene expression of matrix metalloproteinase (MMP), ADAM, and ADAM‐TS
(ADAM with t...
Expression of matrix metalloproteinase 9 (96‐kd gelatinase B) in human rheumatoid arthritis
Wiley - Tập 39 Số 9 - Trang 1576-1587 - 1996
AbstractObjective. To determine the expression of matrix metalloproteinase
9/gelatinase B (MMP‐9) in synovial fluid (SF), plasma, and synovial tissue from
individuals with rheumatoid arthritis (RA), inflammatory arthritis (IA), and
osteoarthritis (OA), using specific monoclonal antibody reagents.Methods.
Gelatinolytic activity in the SF and plasma of patients with RA, IA, and OA was
assessed by ge...
Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities
Wiley - Tập 50 Số 3 - Trang 858-865 - 2004
AbstractObjectiveTo evaluate whether serum matrix metalloproteinase 9 (MMP‐9)
levels are associated with neuropsychiatric manifestations, particularly
cognitive dysfunction, as evaluated by neuropsychological testing and brain
magnetic resonance imaging (MRI) abnormalities in patients with systemic lupus
erythematosus (SLE).MethodsMMP‐9 determinations were made in 44 patients with
SLE and 43 healt...
Association of the PD‐1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
Wiley - Tập 50 Số 6 - Trang 1770-1773 - 2004
AbstractObjectiveTo study the frequency of allele A of polymorphism PD‐1.3 of
the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based
on the presence of rheumatoid factor (RF) and the shared epitope (SE)
alleles.MethodsA total of 1,175 patients with RA and 3,404 controls were
genotyped for the PD‐1.3 A/G polymorphism, which previously was identified as
being involved in su...
Association of interleukin‐18 expression with enhanced levels of both interleukin‐1β and tumor necrosis factor α in knee synovial tissue of patients with rheumatoid arthritis
Wiley - Tập 48 Số 2 - Trang 339-347 - 2003
AbstractObjectiveTo examine the expression patterns of interkeukin‐18 (IL‐18) in
synovial biopsy tissue of patients with rheumatoid arthritis (RA), and to
determine whether expression of this primary cytokine is related to the
expression of other cytokines and adhesion molecules and related to the degree
of joint inflammation.MethodsBiopsy specimens of knee synovial tissue either
without synovitis...
Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone
Wiley - Tập 63 Số 8 - Trang 2385-2395 - 2011
AbstractObjectiveExposure to supraphysiologic levels of glucocorticoid drugs is
known to have detrimental effects on bone formation and linear growth. Patients
with sclerosteosis lack the bone regulatory protein sclerostin, have excessive
bone formation, and are typically above average in height. This study was
undertaken to characterize the effects of a monoclonal antibody to sclerostin
(Scl‐AbI)...
Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody‐driven K/BxN serum–transfer arthritis
Wiley - Tập 58 Số 5 - Trang 1354-1365 - 2008
AbstractObjectiveProstaglandins (PGs) are found in high levels in the synovial
fluid of patients with rheumatoid arthritis, and nonsteroidal blockade of these
bioactive lipids plays a role in patient care. The aim of this study was to
explore the relative contribution of cyclooxygenase (COX) isoforms and PG
species in the autoantibody‐driven K/BxN serum–transfer arthritis.MethodsThe
prostanoid con...
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