Wiley

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The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin‐1 and oncostatin M: A time‐course study using real‐time quantitative reverse transcription–polymerase chain reaction
Wiley - Tập 46 Số 4 - Trang 961-967 - 2002
P. J. T. Koshy, Caroline J. Lundy, Andrew D. Rowan, Sarah Porter, Dylan R. Edwards, Aileen Hogan, Ian M. Clark, Timothy E. Cawston
AbstractObjectivePrevious studies have reported elevated levels of interleukin‐1 (IL‐1) and oncostatin M (OSM) in rheumatoid joints, as well as the synergistic degradation of human articular cartilage by this cytokine combination. The present study was undertaken to investigate the ability of IL‐1 and OSM to modulate gene expressi...... hiện toàn bộ
Expression of matrix metalloproteinase 9 (96‐kd gelatinase B) in human rheumatoid arthritis
Wiley - Tập 39 Số 9 - Trang 1576-1587 - 1996
D Ahrens, A. Koch, Richard M. Pope, M Stein-Picarella, Michael J. Niedbala
AbstractObjective. To determine the expression of matrix metalloproteinase 9/gelatinase B (MMP‐9) in synovial fluid (SF), plasma, and synovial tissue from individuals with rheumatoid arthritis (RA), inflammatory arthritis (IA), and osteoarthritis (OA), using specific monoclonal antibody reagents.Methods... hiện toàn bộ
Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities
Wiley - Tập 50 Số 3 - Trang 858-865 - 2004
Hanna Ainiala, Aki Hietaharju, Prasun Dastidar, Jukka Loukkola, Terho Lehtimäki, Jukka Peltola, Markku Kauppi, T. Heinonen, Seppo T. Nikkari
AbstractObjectiveTo evaluate whether serum matrix metalloproteinase 9 (MMP‐9) levels are associated with neuropsychiatric manifestations, particularly cognitive dysfunction, as evaluated by neuropsychological testing and brain magnetic resonance imaging (MRI) abnormalities in patients with systemic lupus erythematosus (SLE).... hiện toàn bộ
Association of the PD‐1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
Wiley - Tập 50 Số 6 - Trang 1770-1773 - 2004
Ludmila Prokunina‐Olsson, Leonid Padyukov, Anna M. Bennet, Ulf dé Fairé, Björn Wiman, Jonathan A. Prince, Lars Alfredsson, Lars Klareskog, Marta E. Alarcón‐Riquelme
AbstractObjectiveTo study the frequency of allele A of polymorphism PD‐1.3 of the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles.Methods... hiện toàn bộ
Enhanced interferon regulatory factor 3 binding to the interleukin‐23p19 promoter correlates with enhanced interleukin‐23 expression in systemic lupus erythematosus
Wiley - Tập 64 Số 5 - Trang 1601-1609 - 2012
Siobhán Smith, Joan Ní Gabhann, Rowan Higgs, Kevin Stacey, Marie Wahren‐Herlenius, Alexander Espinosa, Maria Grazia Totaro, Antonio Sica, E. Ball, A. L. Bell, James A. Johnston, Peter Browne, Lorraine O’Neill, Grainne Kearns, Caroline A. Jefferies
AbstractObjectiveTo examine the role of interferon regulatory factor 3 (IRF‐3) in the regulation of interleukin‐23 (IL‐23) production in patients with systemic lupus erythematosus (SLE).MethodsBone marrow–derived macrophages were isolated from both wild‐type and IRF3... hiện toàn bộ
No evidence for genetic association of interferon regulatory factor 1 in juvenile idiopathic arthritis
Wiley - Tập 56 Số 3 - Trang 972-976 - 2007
M Fife, Laura Gathercole, Emma Ogilvie, Carmel Stock, Lisa F. Mack, Rachelle Donn, Wendy Thomson, Patricia Woo
AbstractObjectiveJuvenile idiopathic arthritis (JIA) comprises several clinically distinct subgroups and is the most widespread cause of chronic childhood disability. A significant association between JIA and a polymorphism in the interferon regulatory factor 1 (IRF‐1) gene has previously been reported, ...... hiện toàn bộ
Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon‐α activity in lupus patients
Wiley - Tập 62 Số 2 - Trang 553-561 - 2010
Rafah Salloum, Beverly S. Franek, Silvia N. Kariuki, Lesley Rhee, Rachel A. Mikolaitis, Meenakshi Jolly, Tammy O. Utset, Timothy B. Niewold
AbstractObjectiveInterferon‐α (IFNα) is a heritable risk factor for systemic lupus erythematosus (SLE). Genetic variation near IRF7 is implicated in SLE susceptibility. SLE‐associated autoantibodies can stimulate IFNα production through the Toll‐like receptor/IRF7 pathway. This study was undertaken to determine whether variants of...... hiện toàn bộ
Clinical Images: Dramatic amelioration of pneumatosis cystoides intestinalis in systemic sclerosis
Wiley - Tập 62 Số 5 - Trang 1468-1468 - 2010
Yasuhiro Katsumata, Yuko Okamoto, Masaru Shinozaki, Yasushi Kawaguchi, Hisashi Yamanaka
Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor
Wiley - Tập 52 Số 10 - Trang 3020-3029 - 2005
Timothy R. D. J. Radstake, Fred C.G.J. Sweep, Paco M J Welsing, Barbara Franke, Sita H. Vermeulen, Anneke Geurts‐Moespot, Thierry Calandra, Rachelle Donn, Piet L. C. M. van Riel
AbstractObjectiveTo study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF −173G>C and CATT5–8 alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA).Methods... hiện toàn bộ
Increased production of endothelin‐1 in patients with inflammatory arthritides
Wiley - Tập 35 Số 4 - Trang 397-400 - 1992
Nobuyuki Miyasaka, Yukio Hirata, Kenji Andò, Kazuto Sato, H. Morita, Masayoshi Shichiri, Kazuo Kanno, Kimio Tomita, Fumiaki Marumo
AbstractObjective. Endothelin‐1 (ET‐1) is a potent vasoconstrictive peptide, but its precise mechanism of action in vivo has remained unknown.Methods. We measured ET‐1 activity by radioimmunoassay, in both plasma and synovial fluid from patients with inflammatory arthritides.... hiện toàn bộ
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