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Molecular mechanisms of cartilage destruction: Mechanics, inflammatory mediators, and aging collide
Wiley - Tập 54 Số 5 - Trang 1357-1360 - 2006
Richard F. Loeser
Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
Wiley - Tập 56 Số 7 - Trang 2202-2210 - 2007
Snævar Sigurðsson, Leonid Padyukov, Fina Kurreeman, Ulrika Liljedahl, Ann-Christin Wiman, Lars Alfredsson, René E. M. Toes, Johan Rönnelid, Lars Klareskog, T. Huizinga, Gunnar V. Alm, Chris Wallace, Lars Rönnblom
AbstractObjectiveTo determine whether genetic variants of the interferon regulatory factor 5 (IRF‐5) and Tyk‐2 genes are associated with rheumatoid arthritis (RA).MethodsFive single‐nucleotide polymorphisms (SNPs) in IRF5 and 3 SNPs in ... hiện toàn bộ
The effect of low oxygen concentration on growth, glycolysis, and sulfate incorporation by articular chondrocytes in monolayer culture
Wiley - Tập 16 Số 5 - Trang 646-656 - 1973
Ralph E. Marcus, Leon Sokoloff
AbstractRadiosulfate incorporation, DNA synthesis, and glycoiysis by rabbit articular chondrocytes and skin fibrocytes in monolayer culture were compared under different concentrations of oxygen (19, 6.8, 1.3, and 0.6%). Cell for cell, chondrocytes under each condition had higher levels of radiosulfate incorporation and glycolysis than did fibrocytes. Growth of the...... hiện toàn bộ
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin‐1 and oncostatin M: A time‐course study using real‐time quantitative reverse transcription–polymerase chain reaction
Wiley - Tập 46 Số 4 - Trang 961-967 - 2002
P. J. T. Koshy, Caroline J. Lundy, Andrew D. Rowan, Sarah Porter, Dylan R. Edwards, Aileen Hogan, Ian M. Clark, Timothy E. Cawston
AbstractObjectivePrevious studies have reported elevated levels of interleukin‐1 (IL‐1) and oncostatin M (OSM) in rheumatoid joints, as well as the synergistic degradation of human articular cartilage by this cytokine combination. The present study was undertaken to investigate the ability of IL‐1 and OSM to modulate gene expressi...... hiện toàn bộ
Expression of matrix metalloproteinase 9 (96‐kd gelatinase B) in human rheumatoid arthritis
Wiley - Tập 39 Số 9 - Trang 1576-1587 - 1996
D Ahrens, A. Koch, Richard M. Pope, M Stein-Picarella, Michael J. Niedbala
AbstractObjective. To determine the expression of matrix metalloproteinase 9/gelatinase B (MMP‐9) in synovial fluid (SF), plasma, and synovial tissue from individuals with rheumatoid arthritis (RA), inflammatory arthritis (IA), and osteoarthritis (OA), using specific monoclonal antibody reagents.Methods... hiện toàn bộ
Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities
Wiley - Tập 50 Số 3 - Trang 858-865 - 2004
Hanna Ainiala, Aki Hietaharju, Prasun Dastidar, Jukka Loukkola, Terho Lehtimäki, Jukka Peltola, Markku Kauppi, T. Heinonen, Seppo T. Nikkari
AbstractObjectiveTo evaluate whether serum matrix metalloproteinase 9 (MMP‐9) levels are associated with neuropsychiatric manifestations, particularly cognitive dysfunction, as evaluated by neuropsychological testing and brain magnetic resonance imaging (MRI) abnormalities in patients with systemic lupus erythematosus (SLE).... hiện toàn bộ
Association of the PD‐1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope
Wiley - Tập 50 Số 6 - Trang 1770-1773 - 2004
Ludmila Prokunina‐Olsson, Leonid Padyukov, Anna M. Bennet, Ulf dé Fairé, Björn Wiman, Jonathan A. Prince, Lars Alfredsson, Lars Klareskog, Marta E. Alarcón‐Riquelme
AbstractObjectiveTo study the frequency of allele A of polymorphism PD‐1.3 of the PDCD1 gene in patients with rheumatoid arthritis (RA) and its subsets, based on the presence of rheumatoid factor (RF) and the shared epitope (SE) alleles.Methods... hiện toàn bộ
Association of interleukin‐18 expression with enhanced levels of both interleukin‐1β and tumor necrosis factor α in knee synovial tissue of patients with rheumatoid arthritis
Wiley - Tập 48 Số 2 - Trang 339-347 - 2003
Leo A. B. Joosten, Timothy R. D. J. Radstake, Erik Lubberts, L. A. M. Van Den Bersselaar, Piet L. C. M. van Riel, Peter L. E. M. van Lent, Pilar Barrera, Wim B. van den Berg
AbstractObjectiveTo examine the expression patterns of interkeukin‐18 (IL‐18) in synovial biopsy tissue of patients with rheumatoid arthritis (RA), and to determine whether expression of this primary cytokine is related to the expression of other cytokines and adhesion molecules and related to the degree of joint inflammation.... hiện toàn bộ
Sclerostin antibody treatment enhances bone strength but does not prevent growth retardation in young mice treated with dexamethasone
Wiley - Tập 63 Số 8 - Trang 2385-2395 - 2011
Massimo Marenzana, Kevin Greenslade, AdrianL.W.F. Eddleston, Remi Okoye, Daniel Marshall, A R Moore, Martyn K. Robinson
AbstractObjectiveExposure to supraphysiologic levels of glucocorticoid drugs is known to have detrimental effects on bone formation and linear growth. Patients with sclerosteosis lack the bone regulatory protein sclerostin, have excessive bone formation, and are typically above average in height. This study was undertaken to chara...... hiện toàn bộ
Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody‐driven K/BxN serum–transfer arthritis
Wiley - Tập 58 Số 5 - Trang 1354-1365 - 2008
Mei Chen, Éric Boilard, Peter A. Nigrović, Patsy Clark, Daigen Xu, Garret A. FitzGerald, Laurent Audoly, David M. Lee
AbstractObjectiveProstaglandins (PGs) are found in high levels in the synovial fluid of patients with rheumatoid arthritis, and nonsteroidal blockade of these bioactive lipids plays a role in patient care. The aim of this study was to explore the relative contribution of cyclooxygenase (COX) isoforms and PG species in the autoanti...... hiện toàn bộ
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