Wiley
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Peptidomimetics—Tailored Enzyme Inhibitors Abstract Peptides and proteins (there is no clear boundary between the two classes of compounds) are absolutely essential components of organisms in many ways. While proteins have biocatalytic functions and are important components of tissues, peptides play an important role in the organism as hormones, neurotransmitters, and neuromodulators. Peptides and their analogues have long been used in medicinal chemistry as therapeutic agents for pathological conditions generally characterized by a disruption of the interplay between messenger molecules or enzyme substrates and their targets, the receptors and enzymes. For various biochemical and biophysical reasons there is an increasing tendency towards the use of chemical “Trojan horses” known as peptidomimetics. The chances that such agents are active generally increase with the magnitude of the “deceptive effect”, in other words in proportion to the degree of conversion of a peptide into a non‐peptide. Rational design has become a catchphrase which is at present applied frequently to the development of peptidomimetics. New computer programs are invaluable tools in such design processes. However, in spite of the many advances already made, we are still far from the final goal, the de novo design of peptidomimetics. Rational design is nonetheless advancing rapidly, and it is already clear that developments in the area of peptidomimetics have given a great boost to peptide chemistry as a whole. This can be expected to continue, so that in future peptide chemistry may be characterized by a type of symbiotic alliance between peptides and non‐peptides.
Wiley - Tập 33 Số 17 - Trang 1699-1720 - 1994
Oxometallates with Planar Coordination Abstract Oxo compounds whose coordination polyhedra have a planar structure are a rarity in solid state chemistry. The present state of this research area provides a wealth of interesting principles concerning one‐, two‐, and three‐dimensional linkage of square‐planar structural units. In certain cases the environment of these units in solids requires new conceptual models for the chemical bonding.
Wiley - Tập 16 Số 10 - Trang 674-687 - 1977
Substituent Effects in 1,3‐Dipolar Cycloadditions of Phenyl Azide
Wiley - Tập 11 Số 9 - Trang 838-840 - 1972
Proton Transfer, Acid‐Base Catalysis, and Enzymatic Hydrolysis. Part I: ELEMENTARY PROCESSES Abstract The proton occupies a special position as a promoter and mediator in chemical reactions occurring in solution. Many reactions in organic chemistry are catalysed by acids or bases; likewise, most enzymes contain active groups which promote acid‐base catalysis. To understand the reaction mechanisms involved, it is necessary to identify the elementary steps as well as their course in time. Systematic investigation of these elementary steps as well as their course in time. Systematic investigation of these elementary steps has become possible only with the development of new methods for studying very fast reactions. The present paper reviews the information obtained in this type of investigation. The result is a relatively complete picture of the elementary proton transfer mechanisms and a comprehensive description of the modes and laws of acid‐base and enzymatic catalysis.
Wiley - Tập 3 Số 1 - Trang 1-19 - 1964
Selective Enhancement of NMR Signals for α‐Cyclodextrin with Laser‐Polarized Xenon
Wiley - Tập 36 Số 21 - Trang 2368-2370 - 1997
X‐Ray Absorption Spectroscopy on Free Molecules Abstract The most recent spectroscopic method that can be applied to chemical problems is X‐ray absorption spectroscopy, in which the excitation of individual core electrons of an atom is studied. The analysis of the spectra with the aid of simple theoretical models yields information both about the core orbitals of the atom and about the unoccupied molecular orbitals, from which various molecular properties can be deduced. These not only include charge distribution, electronic configuration, geometry, and spatial and energy characteristics of orbitals of the molecule under investigation; one can also obtain parameters of radicals (such as stability, bond length, ionization potential, and electronic excitation energy) that differ from the molecule under investigation in that the nuclear charge of one atom is one unit higher.
Wiley - Tập 13 Số 7 - Trang 454-465 - 1974
Sulfuric Acid from Sulfur Trioxide and Water—A Surprisingly Complex Reaction On paper very simple, but in reality far more complicated —this applies to the formation of sulfuric acid in the atmosphere, which leads to the environmental problem of acid rain. In this reaction sulfur trioxide is transformed into sulfur dioxide, which reacts with water dimers to give sulfuric acid. Ab initio calculations as well as spectroscopic and kinetic studies have yielded new information on the reaction mechanism.
Wiley - Tập 34 Số 12 - Trang 1313-1315 - 1995
Interaction of Hydrophobically‐Modified Poly‐<i>N</i>‐isopropylacrylamides with Model Membranes—or Playing a Molecular Accordion
Wiley - Tập 30 Số 3 - Trang 315-318 - 1991
Enantioselective Catalytic Transfer‐Hydrogenation of α,β‐Unsaturated Carboxylic Acids with Triethylammonium Formate
Wiley - Tập 27 Số 9 - Trang 1180-1181 - 1988
Hydrophobic Effects. Opinions and Facts Abstract The term hydrophobic interactions denotes the tendency of relatively apolar molecules to stick together in aqueous solution. These interactions are of importance in many chemical disciplines, including the chemistry of in vivo processes. Enzyme‐substrate interactions, the assembly of lipids in biomembranes, surfactant aggregation, and kinetic solvent effects in water‐rich solutions are all predominantly governed by hydrophobic interactions. Despite extensive research efforts, the hydration of apolar molecules and the noncovalent interactions between these molecules in water are still poorly understood. In fact, the question as to what the driving force for hydrophobic intractions is shifts the study into a quest for a detailed understanding of the remarkable properties of liquid water. This review highlights some of the novel insights that have been obtained in the past decade. The emphasis is on both hydrophobic hydration and hydrophobic interactions since both phenomena are intimately connected. Several traditional views have been found to be deeply unsatisfactory, and courageous attempts have been made to conceptualize the driving force behind pairwise and bulk hydrophobic interactions. The review presents an admittedly personal selection of the recent experimental and theoretical developments, and when necessary, reference is made to relevant studies of earlier date.
Wiley - Tập 32 Số 11 - Trang 1545-1579 - 1993
Tổng số: 192
- 1
- 2
- 3
- 4
- 5
- 6
- 10