Wiley
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Maternal antioxidant supplementation does not reduce the incidence of phenytoin‐induced cleft lip and related malformations in ratsAbstract There is considerable evidence that phenytoin‐induced birth defects in the rat are a consequence of a period of bradycardia and hypoxia in the embryos. Experiments were designed to test the hypothesis that phenytoin‐induced birth defects result from free‐radical damage to the embryos during the reoxygenation period posthypoxia. Female rats (>9 per group)... ... hiện toàn bộ
Wiley - Tập 74 Số 2 - Trang 201-206 - 2005
Risk of congenital anomalies in pregnant users of non‐steroidal anti‐inflammatory drugs: a nested case‐control studyAbstract BACKGROUND: Many women take non‐steroidal anti‐inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain controversial. We carried out a study to quantify the association between those women prescribed NSAIDs in early pregnancy and congenital anomalies. METHODS: A population‐based pregnancy registry was built by linking data from thre... ... hiện toàn bộ
Wiley - Tập 77 Số 4 - Trang 268-279 - 2006
Evaluation of the reproductive and developmental risks of caffeineAbstract A risk analysis of in utero caffeine exposure is presented utilizing epidemiological studies and animal studies dealing with congenital malformation, pregnancy loss, and weight reduction. These effects are of interest to teratologists, because animal studies are useful in their evaluation. Many of the epidemiology studies did not evaluate the impact of the ... ... hiện toàn bộ
Wiley - Tập 92 Số 2 - Trang 152-187 - 2011
Mercury, cadmium, and arsenite enhance heat shock protein synthesis in chick embryos prior to embryotoxicityAbstract BACKGROUND: Cells respond to adverse environmental stimuli by enhancing the expression of specific genes, the products of which include a suite of proteins known as heat shock proteins (hsps), a response often attributed to cellular protection. METHODS: In this study, we characterized alterations in hsp expressio...
Wiley - Tập 68 Số 6 - Trang 456-464 - 2003
The Effects of Interleukin‐6 Signal Blockade on Fertility, Embryo‐fetal Development, and Immunization In vivoPossible effects of interleukin‐6 (IL ‐6) on reproductive performance, embryonal development, parturition, and postnatal development have been suggested based on protein/mRNA expression level of IL ‐6 in relat... ... hiện toàn bộ
Wiley - Tập 95 Số 4 - Trang 304-317 - 2012
NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A
Wiley - Tập 83 Số 3 - Trang 157-395 - 2008
Species comparison of postnatal CNS development: Functional measures
Wiley - Tập 68 Số 5 - Trang 391-407 - 2003
Two‐generation reproduction study of di‐2‐ethylhexyl terephthalate in Crl:CD ratsAbstract BACKGROUND: This study was conducted to evaluate the potential adverse effects of di‐2‐ethylhexyl terephthalate (DEHT) on reproductive capability from exposure of F0 and F1 parental animals. METHODS: Four groups of male and female Crl:CD (SD)IGS BR rats (30/gender/group)...
Wiley - Tập 80 Số 2 - Trang 69-81 - 2007
PDGF-C Controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells
Wiley - Tập 77 Số 5 - Trang 438-444 - 2006
Developmental toxicity testing for safety assessment: new approaches and technologiesAbstract The ILSI Health and Environmental Sciences Institute's Developmental and Reproductive Toxicology Technical Committee held a 2‐day workshop entitled “Developmental Toxicology—New Directions” in April 2009. The fourth session of this workshop focused on new approaches and technologies for the assessment of developmental toxicology. This session provided an ov... ... hiện toàn bộ
Wiley - Tập 92 Số 5 - Trang 413-420 - 2011
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