Developmental toxicity testing for safety assessment: new approaches and technologies

Wiley - Tập 92 Số 5 - Trang 413-420 - 2011
Thomas B. Knudsen1, Robert J. Kavlock, George P. Daston, Donald B. Stedman, Mary L. Hixon, James H. Kim
1National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. [email protected]

Tóm tắt

AbstractThe ILSI Health and Environmental Sciences Institute's Developmental and Reproductive Toxicology Technical Committee held a 2‐day workshop entitled “Developmental Toxicology—New Directions” in April 2009. The fourth session of this workshop focused on new approaches and technologies for the assessment of developmental toxicology. This session provided an overview of the application of genomics technologies for developmental safety assessment, the use of mouse embryonic stem cells to capture data on developmental toxicity pathways, dynamical cell imaging of zebrafish embryos, the use of computation models of development pathways and systems, and finally, high‐throughput in vitro approaches being utilized by the EPA ToxCast program. Issues discussed include the challenges of anchoring in vitro predictions to relevant in vivo endpoints and the need to validate pathway‐based predictions with targeted studies in whole animals. Currently, there are 10,000 to 30,000 chemicals in world‐wide commerce in need of hazard data for assessing potential health risks. The traditional animal study designs for assessing developmental toxicity cannot accommodate the evaluation of this large number of chemicals, requiring that alternative technologies be utilized. Though a daunting task, technologies are being developed and utilized to make that goal reachable. Birth Defects Res (Part B) 92:413–420, 2011. © 2011 Wiley Periodicals, Inc.

Từ khóa


Tài liệu tham khảo

10.1038/msb.2009.47

10.1126/science.1168755

10.1002/bdrb.20118

10.1093/hmg/ddm303

10.1093/toxsci/kfp202

10.1002/bdrb.20158

10.1126/science.1154619

10.1002/bdra.20344

10.2217/14622416.9.1.35

10.1038/460208a

10.1016/S0278-6915(02)00326-5

IRIS.2010. The US EPA's Integrated Risk Information System (IRIS) is a human health assessment program that evaluates risk information on effects that may result from exposure to environmental contaminants. IRIS provides a publicly accessible database of hazard assessment values for over 550 chemicals available at:http://www.epa.gov/ncea/iris/index.html

10.1016/j.yrtph.2007.11.007

10.1289/ehp.0800168

10.1289/ehp.0901392

10.1046/j.1432-0436.2003.710301.x

10.1006/taap.1993.1056

Kimmel CA, 2006, Developmental and reproductive toxicology, a practical approach

Knudsen TB, 2008, Developmental toxicology,, 3

10.1016/j.reprotox.2009.03.016

10.1093/toxsci/kfl049

10.1126/science.1166154

10.1093/toxsci/kfi198

National Research Council, 2000, Scientific frontiers in developmental toxicology and risk assessment

National Research Council, 2007, Toxicity testing in the 21st century: a vision and a strategy

10.1073/pnas.0806009105

10.1038/nrg2548

10.1126/science.1132292

Singh AV, 2010, Comprehensive toxicology

Thông tin
Thông tin xuất bản

Wiley

Tập 92 Số 5

413-420

Thông tin tác giả