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Expression of human collagenase-3 (MMP-13) by fetal skin fibroblasts is induced by transforming growth factor β via p38 mitogen-activated protein kinase
Wiley - Tập 15 Số 6 - Trang 1098-1100 - 2001
Laura Ravanti, Mervi Toriseva, Risto Penttinen, Timothy M. Crombleholme, Marco Foschi, Jiahuai Han, Veli‐Matti Kähäri
Unique and redundant functions of integrins in the epidermis
Wiley - Tập 24 Số 11 - Trang 4133-4152 - 2010
Coert Margadant, Rabab A. Charafeddine, Arnoud Sonnenberg
Cell calcium and its regulation in smooth muscle
Wiley - Tập 3 Số 11 - Trang 2266-2276 - 1989
Andrew P. Somlyo, Bernard Himpens
Intramitochondrial hydrogen sulfide production by 3‐mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
Wiley - Tập 27 Số 2 - Trang 601-611 - 2013
Katalin Módis, Ciro Coletta, Katalin Erdélyi, Andreas Papapetropoulos, Csaba Szabó
Mechanism of Ca<sub>v</sub>1.2 channel modulation by the amino terminus of cardiac β<sub>2</sub>‐subunits
Wiley - Tập 21 Số 7 - Trang 1527-1538 - 2007
Stefan Herzig, Ismail Khan, Dirk Gründemann, Jan Matthes, A. Ludwig, Guido Michels, Uta C. Hoppe, Dipayan Chaudhuri, Arnold Schwartz, David T. Yue, Roger Hullin
ABSTRACTL‐type calcium channels are composed of a pore, α1c (CaV1.2), and accessory β‐ and α2δ‐subunits. The β‐subunit core structure was recently resolved at high resolution, providing important information on many functional aspects of channel modulation. In this study we reveal differential novel effects of five ß2‐subunits isoforms expressed in human heart ( β 2a‐e) on the single L‐type calcium channel current. These splice variants differ only by amino‐terminal length and amino acid composition. Single‐channel modulation by β2‐subunit isoforms was investigated in HEK293 cells expressing the recombinant L‐type ion conducting pore. All β2‐subunits increased open probability, availability, and peak current with a highly consistent rank order (ß2a≈ ß2b>ß2e≈ ß2c>ß2d). We show graded modulation of some transition rates within and between deep‐closed and inactivated states. The extent of modulation correlates strongly with the length of amino‐terminal domains. Two mutant ß2‐subunits that imitate the natural span related to length confirm this conclusion. The data show that the length of amino termini is a relevant physiological mechanism for channel closure and inactivation, and that natural alternative splicing exploits this principle for modulation of the gating properties of calcium channels.—Herzig, S., Khan, I. F. Y., Gründemarin, D., Matthes, J., Ludwig, A., Michels, G., Hoppe, U. C., Chaudhuri, D., Schwartz, A., Yue, D. T., Hullin, R. Mechanism of Cav1.2 channel modulation by the amino terminus of cardiac ß2‐sub‐units. FASEB J. 21, 1527–1538 (2007)
VEGF‐A promotes tissue repair‐associated lymphatic vessel formation via VEGFR‐2 and the α1β1 and α2β1 integrins
Wiley - Tập 18 Số 10 - Trang 1111-1113 - 2004
Young‐Kwon Hong, Bernhard Lange‐Asschenfeldt, Paula Velasco, Satoshi Hirakawa, Rainer Kunstfeld, Lawrence F. Brown, Peter Böhlen, Donald R. Senger, Michael Detmar
ABSTRACTVascular endothelial growth factor‐A (VEGF‐A) is strongly up‐regulated in wounded cutaneous tissue and promotes repair‐associated angiogenesis. However, little is known about its role in lymphatic regeneration of the healing skin. We studied wound healing in transgenic mice that overexpress VEGF‐A specifically in the epidermis and in wild‐type mice in the absence or presence of inhibitors of VEGF‐A signaling. Surprisingly, transgenic overexpression of VEGF‐A in the skin promoted lymphangiogenesis at the wound healing site, whereas systemic blockade of VEGFR‐2 prevented lymphatic vessel formation. Studies in cultured lymphatic endothelial cells revealed that VEGF‐A induced expression of the α1 and α2 integrins, which promoted their in vitro tube formation and their haptotactic migration toward type I collagen. VEGF‐A‐induced lymphatic endothelial cord formation and haptotactic migration were suppressed by anti‐α1 and anti‐α2 integrin blocking antibodies, and systemic blockade of the α1 and α2 integrins inhibited VEGF‐A‐driven lymphangiogenesis in vivo. We propose that VEGF‐A promotes lymphatic vasculature formation via activation of VEGFR‐2 and that lineage‐specific differences of integrin receptor expression contribute to the distinct dynamics of wound‐associated angiogenesis and lymphangiogenesis.
Abnormal small heat shock protein interactions involving neuropathy‐associated HSP22 (HSPB8) mutants
Wiley - Tập 20 Số 12 - Trang 2168-2170 - 2006
Jean‐Marc Fontaine, Xiankui Sun, Adam D. Hoppe, Stéphanie Simon, Patrick Vicart, Michael J. Welsh, Rainer Benndorf
Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control
Wiley - Tập 18 Số 11 - Trang 1246-1248 - 2004
Dean P. Jones, Young‐Mi Go, Corinna L. Anderson, Thomas R. Ziegler, Joseph M. Kinkade, Ward G. Kirlin
Sulfide, the first inorganic substrate for human cells
Wiley - Tập 21 Số 8 - Trang 1699-1706 - 2007
Marc Goubern, Mireille Andriamihaja, Tobias Nübel, François Blachier, Frédéric Bouillaud
Doxorubicin cardiotoxicity: analysis of prevailing hypotheses
Wiley - Tập 4 Số 13 - Trang 3076-3086 - 1990
Richard D. Olson, Phillip S. Mushlin
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