Wiley
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Chemotherapeutic Potential of <i>Averrhoa bililmbi</i> Leaves Ethanolic Extracts Against Human Colorectal Carcinoma through Anti‐inflammatory Activity in Murine RAW 264.7 Macrophage Cells and Anti‐proliferative Activities Against HT‐29 Human Colorectal Carcinoma Chronic inflammation and cancer are already known to be two intertwined processes and many studies have suggested that the hindrance of the former can serve as an effective preventive measure for the occurrence of colorectal carcinoma (CRC). The current study was done in order to evaluate both the anti‐inflammatory and cytotoxic properties of ethanol extracts of Averrhoa bilimbi leaves in light of its potential as a source of an effective chemotherapeutic agent against CRC. In this study, RAW 264.7 murine macrophage cells and HT‐29 human colorectal carcinoma cells were used to evaluate the anti‐inflammatory and anti‐tumor properties of the extract, respectively. Cell viability analysis, NO assay, RT‐PCR assay, Western blot analysis, flow cytometry analysis and antioxidant assays were used to evaluate the chemotherapeutic properties of the extract. It was shown that treatment with low doses (25, 50 and 100 μg/mL) of the extract has potent anti‐inflammatory activity through alterations in nuclear factor‐kappa B (NF‐KB) activity, nitric oxide (NO) production and cycloxygenase‐2 (COX‐2) release. The extract also shows potent cytotoxic activity against the cancer cell line used in the study. It was seen that the extract shows anti‐tumor properties through the promotion of apoptosis, through up regulation of the Smac/DIABLO‐caspase cascade, and cell cycle arrest, through up regulation of the tumor suppressor gene p21. Antioxidant screening showed that the extract possesses antioxidant activity supporting its anti‐inflammatory and anticancer activities. In conclusion, the current study shows that Averrhoa bilimbi can be a source of bioactive compounds which can be used as a potential chemotherapeutic agent against colorectal carcinoma by virtue of its chemopreventive (anti‐inflammatory) and chemotoxic (cytotoxic) properties.
Wiley - Tập 30 Số S1 - 2016
The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification <sup>1</sup>
Wiley - Tập 9 Số 8 - Trang 576-596 - 1995
Wound healing can be improved by (—)‐epigallocatechin gallate through targeting Notch in streptozotocin‐induced diabetic mice ABSTRACT Delayed wound healing is one of the most prominent clinical manifestations of diabetes and lacks satisfactory treatment options. Persistent inflammation occurs in the late phase of wound healing and impairs the healing process in mice with diabetes mellitus (DM). In this study, we observed that the late wound healing in streptozotocin (STZ)‐induced DM mice could be improved by (−)‐epigallocatechin gallate (EGCG). The macrophage accumulation, inflammation response, and Notch signaling can be inhibited by EGCG in the skin wounds of DM mice. Furthermore, we found that the LPS‐induced inflammation response including overactivated Notch signaling, was inhibited by EGCG in mouse macrophages. Moreover, we confirmed that EGCG could directly bind with mouse Notch‐1. In addition, our studies indicated that diabetic wound healing was improved by EGCG treatment before or after the inflammation phase by targeting the Notch signaling pathway, which suggests that the pre‐existing diabetic wound healing can be improved by EGCG. To summarize, wound healing can be improved by EGCG through targeting Notch in STZ‐induced DM mice. Our findings provide insight into the therapeutic strategy for diabetic wounds and offer EGCG as a novel potential medicine to treat chronic wounds.—Huang, Y.‐W., Zhu,Q.‐Q., Yang,X.‐Y., Xu,H.‐H., Sun,B., Wang,X.‐J., Sheng,J.Wound healing can be improved by (−)‐epigallocatechin gallate through targeting Notch in streptozotocin‐induced diabetic mice. FASEB J. 33, 953–964 (2019). www.fasebj.org
Wiley - Tập 33 Số 1 - Trang 953-964 - 2019
Intercellular transfer of transferrin receptor by a contact‐, Rab8‐dependent mechanism involving tunneling nanotubes
Wiley - Tập 29 Số 11 - Trang 4695-4712 - 2015
Differential regulation of proteasome functionality in reproductive <i>vs.</i> somatic tissues of <i>Drosophila</i> during aging or oxidative stress
Wiley - Tập 27 Số 6 - Trang 2407-2420 - 2013
The animal fatty acid synthase: one gene, one polypeptide, seven enzymes
Wiley - Tập 8 Số 15 - Trang 1248-1259 - 1994
The glycoprotein hormones: recent studies of structure‐function relationships
Wiley - Tập 2 Số 11 - Trang 2661-2669 - 1988
LDL receptor‐related protein: a multiligand receptor for lipoprotein and proteinase catabolism
Wiley - Tập 9 Số 10 - Trang 890-898 - 1995
Exercise during pregnancy mitigates Alzheimer‐like pathology in mouse offspring
Wiley - Tập 26 Số 1 - Trang 117-128 - 2012
Exercise‐induced promotion of hippocampal cell proliferation requires β‐endorphin
Wiley - Tập 22 Số 7 - Trang 2253-2262 - 2008
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