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Wiley

  0892-6638

  1530-6860

 

Cơ quản chủ quản:  John Wiley & Sons Inc. , WILEY

Lĩnh vực:
BiochemistryMedicine (miscellaneous)GeneticsBiotechnologyMolecular Biology

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Các bài báo tiêu biểu

Chemotherapeutic Potential of <i>Averrhoa bililmbi</i> Leaves Ethanolic Extracts Against Human Colorectal Carcinoma through Anti‐inflammatory Activity in Murine RAW 264.7 Macrophage Cells and Anti‐proliferative Activities Against HT‐29 Human Colorectal Carcinoma
Tập 30 Số S1 - 2016
Emil Joseph Sanvictores Vergara, Yeon Soo Kim, Wenchie Marie Lara Lumbera, Thùy Linh Nguyễn, Joseph dela Cruz, Seong Gu Hwang
Chronic inflammation and cancer are already known to be two intertwined processes and many studies have suggested that the hindrance of the former can serve as an effective preventive measure for the occurrence of colorectal carcinoma (CRC). The current study was done in order to evaluate both the anti‐inflammatory and cytotoxic properties of ethanol extracts of Averrhoa bilimbi leaves in light of its potential as a source of an effective chemotherapeutic agent against CRC. In this study, RAW 264.7 murine macrophage cells and HT‐29 human colorectal carcinoma cells were used to evaluate the anti‐inflammatory and anti‐tumor properties of the extract, respectively. Cell viability analysis, NO assay, RT‐PCR assay, Western blot analysis, flow cytometry analysis and antioxidant assays were used to evaluate the chemotherapeutic properties of the extract. It was shown that treatment with low doses (25, 50 and 100 μg/mL) of the extract has potent anti‐inflammatory activity through alterations in nuclear factor‐kappa B (NF‐KB) activity, nitric oxide (NO) production and cycloxygenase‐2 (COX‐2) release. The extract also shows potent cytotoxic activity against the cancer cell line used in the study. It was seen that the extract shows anti‐tumor properties through the promotion of apoptosis, through up regulation of the Smac/DIABLO‐caspase cascade, and cell cycle arrest, through up regulation of the tumor suppressor gene p21. Antioxidant screening showed that the extract possesses antioxidant activity supporting its anti‐inflammatory and anticancer activities. In conclusion, the current study shows that Averrhoa bilimbi can be a source of bioactive compounds which can be used as a potential chemotherapeutic agent against colorectal carcinoma by virtue of its chemopreventive (anti‐inflammatory) and chemotoxic (cytotoxic) properties.
Wound healing can be improved by (—)‐epigallocatechin gallate through targeting Notch in streptozotocin‐induced diabetic mice
Tập 33 Số 1 - Trang 953-964 - 2019
Yewei Huang, Qiangqiang Zhu, Xiaoying Yang, Huanhuan Xu, Bin Sun, Xuanjun Wang, Jun Sheng
ABSTRACTDelayed wound healing is one of the most prominent clinical manifestations of diabetes and lacks satisfactory treatment options. Persistent inflammation occurs in the late phase of wound healing and impairs the healing process in mice with diabetes mellitus (DM). In this study, we observed that the late wound healing in streptozotocin (STZ)‐induced DM mice could be improved by (−)‐epigallocatechin gallate (EGCG). The macrophage accumulation, inflammation response, and Notch signaling can be inhibited by EGCG in the skin wounds of DM mice. Furthermore, we found that the LPS‐induced inflammation response including overactivated Notch signaling, was inhibited by EGCG in mouse macrophages. Moreover, we confirmed that EGCG could directly bind with mouse Notch‐1. In addition, our studies indicated that diabetic wound healing was improved by EGCG treatment before or after the inflammation phase by targeting the Notch signaling pathway, which suggests that the pre‐existing diabetic wound healing can be improved by EGCG. To summarize, wound healing can be improved by EGCG through targeting Notch in STZ‐induced DM mice. Our findings provide insight into the therapeutic strategy for diabetic wounds and offer EGCG as a novel potential medicine to treat chronic wounds.—Huang, Y.‐W., Zhu,Q.‐Q., Yang,X.‐Y., Xu,H.‐H., Sun,B., Wang,X.‐J., Sheng,J.Wound healing can be improved by (−)‐epigallocatechin gallate through targeting Notch in streptozotocin‐induced diabetic mice. FASEB J. 33, 953–964 (2019). www.fasebj.org
Intercellular transfer of transferrin receptor by a contact‐, Rab8‐dependent mechanism involving tunneling nanotubes
Tập 29 Số 11 - Trang 4695-4712 - 2015
Anne Burtey, Marek Wagner, Erlend Hodneland, Kai Ove Skaftnesmo, Julia Schoelermann, Ivan Rios Mondragon, Heidi Espedal, Anna Golebiewska, Simone P. Niclou, Rolf Bjerkvig, Tanja Kögel, Hans‐Hermann Gerdes
Differential regulation of proteasome functionality in reproductive <i>vs.</i> somatic tissues of <i>Drosophila</i> during aging or oxidative stress
Tập 27 Số 6 - Trang 2407-2420 - 2013
Eleni N. Tsakiri, Gerasimos P. Sykiotis, Issidora S. Papassideri, Varda Rotter, Dirk Bohmann, Ioannis P. Trougakos
The animal fatty acid synthase: one gene, one polypeptide, seven enzymes
Tập 8 Số 15 - Trang 1248-1259 - 1994
Sean C. Smith
The glycoprotein hormones: recent studies of structure‐function relationships
Tập 2 Số 11 - Trang 2661-2669 - 1988
Robert J. Ryan, M. Cristine Charlesworth, Daniel McCormick, Robert P. Milius, Henry T. Keutmann
LDL receptor‐related protein: a multiligand receptor for lipoprotein and proteinase catabolism
Tập 9 Số 10 - Trang 890-898 - 1995
Dudley K. Strickland, Maria Z. Kounnas, W. Scott Argraves
Exercise during pregnancy mitigates Alzheimer‐like pathology in mouse offspring
Tập 26 Số 1 - Trang 117-128 - 2012
Arne Herring, Anja Donath, Maksym Yarmolenko, Ellen Uslar, Catharina Conzen, Dimitrios Kanakis, Claudius Bosma, Karl Worm, Werner Paulus, Kathy Keyvani
Exercise‐induced promotion of hippocampal cell proliferation requires β‐endorphin
Tập 22 Số 7 - Trang 2253-2262 - 2008
Muriel Koehl, Peter Meerlo, Delphine Gonzales, A. Rontal, Fred W. Turek, Djoher Nora Abrous