The Epidemiology of Peripheral Arterial Disease: Importance of Identifying the Population at Risk Tập 2 Số 3 - Trang 221-226 - 1997
Michael H. Criqui, Julie O. Denenberg, Robert D. Langer, Arnost Fronek
Data from the Framingham Study and other population studies indicate that
intermittent claudication (IC) sharply increases in late middle age and is
somewhat higher among men than women. Noninvasive testing in populations
indicates that the true prevalence of peripheral arterial disease (PAD) is at
least five times higher than would be expected based on the reported prevalence
of IC. Peripheral ar... hiện toàn bộ
The Correlation between Symptoms and Non-Invasive Test Results in Patients Referred for Peripheral Arterial Disease Testing Tập 1 Số 1 - Trang 65-71 - 1996
Michael H. Criqui, Julie O. Denenberg, Cameron E Bird, A Fronĕk, Melville R. Klauber, Robert D. Langer
The WHO/Rose questionnaire has served as the epidemiologic and clinical standard
in the assessment of leg pain in patients with peripheral arterial disease (PAD)
for over three decades. However, the structure of this questionnaire does not
allow assessment of leg-specific (i.e. right versus left) symptoms. We studied
508 patients aged 39–95 years (mean 68 years), initially referred for PAD
non-inv... hiện toàn bộ
Collagens in the progression and complications of atherosclerosis Tập 14 Số 1 - Trang 73-89 - 2009
Eser Adiguzel, Pamela J. Ahmad, Christopher Franco, Michelle P. Bendeck
Abstract Collagens constitute a major portion of the extracellular matrix in the
atherosclerotic plaque, where they contribute to the strength and integrity of
the fibrous cap, and also modulate cellular responses via specific receptors and
signaling pathways. This review focuses on the diverse roles that collagens play
in atherosclerosis; regulating the infiltration and differentiation of smooth
... hiện toàn bộ
The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function Tập 7 Số 3 - Trang 213-225 - 2002
Renke Maas, Edzard Schwedhelm, Jennifer Albsmeier, Rainer H. Böger
The incidence of erectile dysfunction increases with diabetes, hypertension,
hypercholesterolaemia, cardiovascular disease and renal failure. All these
conditions are associated with endothelial dysfunction. This review addresses
the pathophysiology of erectile dysfunction with a special focus on new insights
into nitric oxide (NO)-mediated pathways, oxidative stress and parallels to
endothelial d... hiện toàn bộ
Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia Tập 7 Số 3 - Trang 227-239 - 2002
Norbert Weiss, C. Keller, Ulrich Hoffmann, Joseph Loscalzo
Mildly elevated plasma homocysteine levels are an independent risk factor for
atherothrombotic vascular disease in the coronary, cerebrovascular, and
peripheral arterial circulation. Endothelial dysfunction as manifested by
impaired endothelium-dependent regulation of vascular tone and blood flow, by
increased recruitment and adhesion of circulating inflammatory cells to the
endothelium, and by a ... hiện toàn bộ
Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease Tập 12 Số 2 - Trang 113-122 - 2007
Steven R. Steinhubl, Juan J. Badimón, Deepak L. Bhatt, Jean‐Marc Herbert, Thomas F. Lüscher
Recent advances in our understanding of cardiovascular disease have revealed
that atherothrombotic events, such as myocardial infarction and ischemic stroke,
are the end result of a complex inflammatory response to multifaceted vascular
pathology. As well as initiating thrombus formation at the site of a ruptured
atherosclerotic plaque, platelets play a key role in vascular inflammation,
through r... hiện toàn bộ
Functional outcomes and quality of life in peripheral arterial disease: current status Tập 8 Số 2 - Trang 115-126 - 2003
Mark R. Nehler, Mary Mcdermott, Diane Treat‐Jacobson, Giancarlo Agnelli, Judith G. Regensteiner
This review examines current evidence for baseline functional impairment and
changes with therapy in patients with peripheral arterial disease (PAD) -
ranging from patients without claudication or critical limb ischemia (CLI) but
other exertional leg symptoms (erroneously referred to as asymptomatic in the
Fontaine classifi cation system), to patients with claudication and those with
CLI. The revi... hiện toàn bộ
Exercise Testing and Exercise Rehabilitation for Patients with Peripheral Arterial Disease: Status in 1997 Tập 2 Số 2 - Trang 147-155 - 1997
Judith G. Regensteiner, Andrew W. Gardner, William R. Hiatt
Intermittent claudication is a common manifestation of peripheral arterial
occlusive disease (PAOD). Patients with claudication are limited in terms of
work, housework and leisure activities so that functional status is very
impaired. Therefore, the goals for treatment should focus on improving the
functional impairment as well as on modifying risk factors. Evaluation of the
functional status is o... hiện toàn bộ
The role of optical coherence tomography in vascular medicine Tập 14 Số 1 - Trang 63-71 - 2009
Muhammad Farooq, Atul Khasnis, Arshad Majid, Mounzer Kassab
Abstract Optical coherence tomography (OCT) is an emerging imaging modality that
provides high-resolution, microstructural information on atherosclerotic plaques
in biological systems. Intracoronary OCT can identify thin-cap fibroatheroma and
other vulnerable plaques that may be responsible for acute coronary events.
These characteristics make OCT helpful in guiding coronary management and
interve... hiện toàn bộ
Association of anger proneness, depression and low social support with peripheral arterial disease: the Atherosclerosis Risk in Communities Study Tập 10 Số 3 - Trang 199-206 - 2005
Keattiyoat Wattanakit, Janice E. Williams, Pamela J. Schreiner, Alan T. Hirsch, Aaron R. Folsom
There is mounting evidence to suggest that psychosocial factors, including anger
proneness, depression and social isolation, are risk factors for cardiovascular
disease. Nevertheless, evidence relating these factors to peripheral arterial
disease (PAD) and intermittent claudication remains sparse. Using data from the
Atherosclerosis Risk in Communities Study, we analyzed the relationship of
psycho... hiện toàn bộ