Vascular Medicine
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Ankle—brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohort
Vascular Medicine - Tập 12 Số 4 - Trang 267-273 - 2007
To determine whether elevated levels of hemostatic and inflammatory markers [von
Willebrand factor (vWF), fibrinogen, D-dimer, factor VII, factor VIII, PAI-1,
tPA, beta-thromboglobulin (β-TG), CRP, and WBC count] are associated with
increased peripheral arterial disease (PAD) prevalence, measured by low ABI, we
studied 13,778 participants from the ARIC study in a cross-sectional analysis
after adj...
Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease
Vascular Medicine - Tập 12 Số 2 - Trang 113-122 - 2007
Recent advances in our understanding of cardiovascular disease have revealed
that atherothrombotic events, such as myocardial infarction and ischemic stroke,
are the end result of a complex inflammatory response to multifaceted vascular
pathology. As well as initiating thrombus formation at the site of a ruptured
atherosclerotic plaque, platelets play a key role in vascular inflammation,
through r...
Effect of aspirin on short-term outcomes in hospitalized patients with COVID-19
Vascular Medicine - Tập 26 Số 6 - Trang 626-632 - 2021
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is an ongoing viral
pandemic marked by increased risk of thrombotic events. However, the role of
platelets in the elevated observed thrombotic risk in COVID-19 and utility of
antiplatelet agents in attenuating thrombosis is unknown. We aimed to determine
if the antiplatelet effect of aspirin may mitigate risk of myocardial
infarction, cerebr...
The role of optical coherence tomography in vascular medicine
Vascular Medicine - Tập 14 Số 1 - Trang 63-71 - 2009
Abstract Optical coherence tomography (OCT) is an emerging imaging modality that
provides high-resolution, microstructural information on atherosclerotic plaques
in biological systems. Intracoronary OCT can identify thin-cap fibroatheroma and
other vulnerable plaques that may be responsible for acute coronary events.
These characteristics make OCT helpful in guiding coronary management and
interve...
Role of Endothelial Cells in Allograft Rejection
Vascular Medicine - Tập 2 Số 2 - Trang 105-114 - 1997
The immunological properties of endothelial cells suggest they perform a pivotal
role in acute and chronic rejection following solid organ transplantation. Their
constitutive expression of MHC class II molecules (which initiate allograft
rejection by activating CD4 T cells) and accessory molecules allows them to
present foreign antigen by both the direct and indirect route to the recipient's
immun...
Collagens in the progression and complications of atherosclerosis
Vascular Medicine - Tập 14 Số 1 - Trang 73-89 - 2009
Abstract Collagens constitute a major portion of the extracellular matrix in the
atherosclerotic plaque, where they contribute to the strength and integrity of
the fibrous cap, and also modulate cellular responses via specific receptors and
signaling pathways. This review focuses on the diverse roles that collagens play
in atherosclerosis; regulating the infiltration and differentiation of smooth
...
Cardiovascular predictors for long-term mortality after EVAR for AAA
Vascular Medicine - Tập 16 Số 6 - Trang 422-427 - 2011
The aim of this study was to assess cardiovascular predictors for all-cause
long-term mortality in patients undergoing standard endovascular aneurysm repair
(EVAR) for infrarenal abdominal aortic aneurysm (AAA). Consecutive patients
treated with EVAR (Zenith® stent grafts; Cook) between May 1998 and February
2006 were prospectively enrolled in a computerized database, together with
retrospectively...
Beneficial effect of statins on total mortality in abdominal aortic aneurysm (AAA) repair
Vascular Medicine - Tập 22 Số 5 - Trang 406-410 - 2017
In this single center, retrospective cohort study we wished to compare early and
total mortality for all patients treated for abdominal aortic aneurysms (AAA)
with open surgery who were taking statins compared to those who were not. A
cohort of 640 patients with AAA was treated with open surgery between 1999 and
2012. Patients were consecutively recruited from a source population of 390,000;
21.3%...
The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function
Vascular Medicine - Tập 7 Số 3 - Trang 213-225 - 2002
The incidence of erectile dysfunction increases with diabetes, hypertension,
hypercholesterolaemia, cardiovascular disease and renal failure. All these
conditions are associated with endothelial dysfunction. This review addresses
the pathophysiology of erectile dysfunction with a special focus on new insights
into nitric oxide (NO)-mediated pathways, oxidative stress and parallels to
endothelial d...
A systematic review of the sensitivity and specificity of the toe–brachial index for detecting peripheral artery disease
Vascular Medicine - Tập 21 Số 4 - Trang 382-389 - 2016
The toe–brachial index (TBI) is used as an adjunct to the ankle–brachial index
(ABI) for non-invasive lower limb vascular screening. With increasing evidence
suggesting limitations of the ABI for diagnosis of vascular complications,
particularly in specific populations including diabetes cohorts, the TBI is
being used more widely. The aim of this review was to determine the sensitivity
and specifi...
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