Theoretical Biology and Medical Modelling
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A novel approach to the analysis of human growth
Theoretical Biology and Medical Modelling - Tập 9 - Trang 1-15 - 2012
Several formulations have been proposed in order to model human growth from birth to maturity. They are usually based on “ad hoc” heuristic assumptions. In the present contribution we adopt, as an alternative, a completely general (interdisciplinary) approach, based on the formalism of the Phenomenological Universalities (PUN). The main PUN class investigated to date, i.e. UN, can only account for......
Application of methods of identifying receptor binding models and analysis of parameters
Theoretical Biology and Medical Modelling - Tập 1 Số 1 - Trang 1-4 - 2004
Possible methods for distinguishing receptor binding models and analysing their parameters are considered. The conjugate gradients method is shown to be optimal for solving problems of the kind considered. Convergence with experimental data is rapidly achieved with the appropriate model but not with alternative models. Lack of convergence using the conjugate gradients method can be taken to indica......
Dimensional analysis yields the general second-order differential equation underlying many natural phenomena: the mathematical properties of a phenomenon’s data plot then specify a unique differential equation for it
Theoretical Biology and Medical Modelling - Tập 11 - Trang 1-21 - 2014
This study uses dimensional analysis to derive the general second-order differential equation that underlies numerous physical and natural phenomena described by common mathematical functions. It eschews assumptions about empirical constants and mechanisms. It relies only on the data plot’s mathematical properties to provide the conditions and constraints needed to specify a second-order different......
The organelle of differentiation in embryos: the cell state splitter
Theoretical Biology and Medical Modelling - Tập 13 - Trang 1-35 - 2016
The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring and an intermediate filament ring subtending a microtubule mat. The microtubules and microfilament ring are in mechanical opposition as in a tensegrity structure. The cell state splitter is bistable, perturbations causing it to contract or expand......
An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis
Theoretical Biology and Medical Modelling - Tập 10 - Trang 1-19 - 2013
In this paper we propose a chemical physics mechanism for the initiation of the glycolytic switch commonly known as the Warburg hypothesis, whereby glycolytic activity terminating in lactate continues even in well-oxygenated cells. We show that this may result in cancer via mitotic failure, recasting the current conception of the Warburg effect as a metabolic dysregulation consequent to cancer, to......
Analysis of inter-patient variations in tumour growth rate
Theoretical Biology and Medical Modelling - Tập 11 - Trang 1-11 - 2014
Inter-patient variations in tumour growth rate are usually interpreted as biological heterogeneity among patients due to, e.g., genetic variability. However, these variations might be a result of non-exponential, e.g. the Gompertzian, tumour growth kinetics. The aim was to study if the natural tumour growth deceleration, i.e. non-exponential growth, is a dominant factor in such variations. The cor......
Regulatory role of E-NTPase/E-NTPDase in Ca2+/Mg2+ transport via gated channel
Theoretical Biology and Medical Modelling - Tập 1 - Trang 1-12 - 2004
E-NTPase/E-NTPDase is activated by millimolar concentrations of Ca2+ or Mg2+ with a pH optimum of 7.5 for the hydrolysis of extracellular NTP and NDP. It has been generally accepted that E-NTPase/E-NTPDase plays regulatory role in purinergic signalling, but other functions may yet be discovered. In this article it is proposed on the basis of published data that E-NTPase/E-NTPDase could play a role......
Does reservoir host mortality enhance transmission of West Nile virus?
Theoretical Biology and Medical Modelling - Tập 4 - Trang 1-9 - 2007
Since its 1999 emergence in New York City, West Nile virus (WNV) has become the most important and widespread cause of mosquito-transmitted disease in North America. Its sweeping spread from the Atlantic to the Pacific coast was accompanied by widespread mortality among wild birds, especially corvids. Only sporadic avian mortality had previously been associated with this infection in the Old World......
Cardiac dynamics: a simplified model for action potential propagation
Theoretical Biology and Medical Modelling - Tập 9 - Trang 1-18 - 2012
This paper analyzes a new semiphysiological ionic model, used recently to study reexitations and reentry in cardiac tissue [I.R. Cantalapiedra et al, PRE 82 011907 (2010)]. The aim of the model is to reproduce action potencial morphologies and restitution curves obtained, either from experimental data, or from more complex electrophysiological models. The model divides all ion currents into four g......
Development of global consensus sequence of HCV glycoproteins involved in viral entry
Theoretical Biology and Medical Modelling - Tập 10 Số 1 - 2013
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