Theoretical Biology and Medical Modelling

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Nucleic acid chaperons: a theory of an RNA-assisted protein folding
Theoretical Biology and Medical Modelling - - 2005
Jan C Biro
Proteins are assumed to contain all the information necessary for unambiguous folding (Anfinsen's principle). However, ab initio structure prediction is often not successful because the amino acid sequence itself is not sufficient to guide between endless folding possibilities. It seems to be a logical to try to find the "missing" information in nucleic acids, in the redundant codon base. mRNA ene...... hiện toàn bộ
Sự bao gồm của thụ thể glucocorticoid trong mô hình trục hạ đồi - tuyến yên - tuyến thượng thận cho thấy sự tồn tại hai trạng thái ổn định Dịch bởi AI
Theoretical Biology and Medical Modelling - - 2007
Shakti Gupta, Eric Aslakson, Brian M. Gurbaxani, Suzanne D. Vernon
Tóm tắt Nền tảng Hệ thống quản lý stress chủ yếu của cơ thể là trục hạ đồi - tuyến yên - tuyến thượng thận (HPA). Trục HPA phản ứng với các thách thức về thể chất và tinh thần để duy trì sự ổn định nội môi một phần bằng cách kiểm soát mức cortisol trong cơ thể. Sự rối loạn chức năng của trục HPA ...... hiện toàn bộ
Modeling methods for estimating HIV incidence: a mathematical review
Theoretical Biology and Medical Modelling - Tập 17 - Trang 1-14 - 2020
Xiaodan Sun, Hiroshi Nishiura, Yanni Xiao
Estimating HIV incidence is crucial for monitoring the epidemiology of this infection, planning screening and intervention campaigns, and evaluating the effectiveness of control measures. However, owing to the long and variable period from HIV infection to the development of AIDS and the introduction of highly active antiretroviral therapy, accurate incidence estimation remains a major challenge. ...... hiện toàn bộ
Computer simulation of cervical tissue response to a hydraulic dilator device
Theoretical Biology and Medical Modelling - Tập 10 - Trang 1-9 - 2013
Nenad Filipovic, Dalibor Nikolic, Igor Saveljic, Irena Tanaskovic, Nebojsa Zdravkovic, Aleksandar Zivanovic, Petar Arsenijevic, Branislav Jeremic, Slobodan Arsenijevic
Classical mechanical dilators for cervical dilation are associated with various complications, such as uterine perforation, cervical laceration, infections and intraperitoneal hemorrhage. A new medical device called continuous controllable balloon dilator (CCBD) was constructed to make a significant reduction in all of the side effects of traditional mechanical dilation. In this study we investiga...... hiện toàn bộ
Can visco-elastic phase separation, macromolecular crowding and colloidal physics explain nuclear organisation?
Theoretical Biology and Medical Modelling - Tập 4 - Trang 1-11 - 2007
Francisco J Iborra
The cell nucleus is highly compartmentalized with well-defined domains, it is not well understood how this nuclear order is maintained. Many scientists are fascinated by the different set of structures observed in the nucleus to attribute functions to them. In order to distinguish functional compartments from non-functional aggregates, I believe is important to investigate the biophysical nature o...... hiện toàn bộ
Application of neural oscillators to study the effects of walking speed on rhythmic activations at the ankle
Theoretical Biology and Medical Modelling - Tập 10 - Trang 1-11 - 2013
Sook-Yee Chong, Heiko Wagner, Arne Wulf
Spinal pattern generators (SPG) are neural networks in the spinal cord that do not require a central input from the brain to generate a motor output. We wanted to determine whether SPG can adapt to the changing motor demands from walking at different speeds, and performing silly walks. An SPG model consisting of an oscillator made up of two neurons was utilised in this study; one neuron activates ...... hiện toàn bộ
Erratum to: modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors
Theoretical Biology and Medical Modelling - Tập 9 - Trang 1-1 - 2012
Piernicola Pedicini, Rocchina Caivano, Barbara A Jereczek-Fossa, Lidia Strigari, Barbara Vischioni, Daniela Alterio, Marta Cremonesi, Francesca Botta, Antonio Nappi, Giuseppina Improta, Giovanni Storto, Alba Fiorentino, Marcello Benassi, Roberto Orecchia, Vincenzo Fusco
Tyrosine phosphorylation of myosin heavy chain during skeletal muscle differentiation: an integrated bioinformatics approach
Theoretical Biology and Medical Modelling - Tập 2 Số 1 - 2005
Donal Harney, Ryan K. Butler, Richard J. Edwards
Abstract Background Previously it has been shown that insulin-mediated tyrosine phosphorylation of myosin heavy chain is concomitant with enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. We sought to identify putative site(s) for this phosphorylation event.... hiện toàn bộ
Explaining individual variation in patterns of mass loss in breeding birds
Theoretical Biology and Medical Modelling - Tập 3 - Trang 1-8 - 2006
Sean A Rands, Innes C Cuthill, Alasdair I Houston
Studies of birds have a disproportionate representation in the literature on life-history evolution, because of the (apparent) ease with which the costs and benefits can be quantified and manipulated. During reproduction, birds frequently show a highly conserved pattern of mass change and changes in mass loss during breeding have been widely considered to be a valid short-term measure of the costs...... hiện toàn bộ
A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
Theoretical Biology and Medical Modelling - Tập 8 Số 1 - 2011
Péter Buchwald
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