Dynamics of glucose and insulin concentration connected to the β‐cell cycle: model development and analysisTheoretical Biology and Medical Modelling - Tập 9 - Trang 1-22 - 2012
Martina Gallenberger, Wolfgangzu Castell, Burkhard A Hense, Christina Kuttler
Diabetes mellitus is a group of metabolic diseases with increased blood glucose concentration as the main symptom. This can be caused by a relative or a total lack of insulin which is produced by the β‐cells in the pancreatic islets of Langerhans. Recent experimental results indicate the relevance of the β‐cell cycle for the development of diabetes mellitus. This paper introduces a mathematical mo...... hiện toàn bộ
Nucleic acid chaperons: a theory of an RNA-assisted protein foldingTheoretical Biology and Medical Modelling - - 2005
Jan C Biro
Proteins are assumed to contain all the information necessary for unambiguous folding (Anfinsen's principle). However, ab initio structure prediction is often not successful because the amino acid sequence itself is not sufficient to guide between endless folding possibilities. It seems to be a logical to try to find the "missing" information in nucleic acids, in the redundant codon base. mRNA ene...... hiện toàn bộ
Mathematical modelling of spatio-temporal glioma evolutionTheoretical Biology and Medical Modelling - Tập 10 - Trang 1-31 - 2013
Maria Papadogiorgaki, Panagiotis Koliou, Xenofon Kotsiakis, Michalis E Zervakis
Gliomas are the most common types of brain cancer, well known for their aggressive proliferation and the invasive behavior leading to a high mortality rate. Several mathematical models have been developed for identifying the interactions between glioma cells and tissue microenvironment, which play an important role in the mechanism of the tumor formation and progression. Building and expanding on ...... hiện toàn bộ
Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patientsTheoretical Biology and Medical Modelling - Tập 16 - Trang 1-18 - 2019
Hamed Ghaffari, Jeffrey D. Varner, Linda R. Petzold
Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation (DIC). However, the mechanisms underlying this improvement have yet to be elucidated. In vitro studies have reported that RA upregulates thrombomodulin (TM) expression on the endo...... hiện toàn bộ
Nghiên cứu lâm sàng về ảnh hưởng của ngộ độc chì đối với khả năng trí tuệ và hành vi thần kinh của trẻ em Dịch bởi AI Theoretical Biology and Medical Modelling - - 2013
Shuangxing Hou, Yuan Lv, Pengpeng Jin, B. Ding, Na Qin, L i Li, Xuedong Liu, Wu Z, Gang Zhao, Yanchun Deng
Tóm tắt
Đặt vấn đề
Chì là một kim loại nặng và chất độc hại quan trọng đối với môi trường, đồng thời là chất độc thần kinh có thể gây hại cho nhiều chức năng của hệ thần kinh. Ngộ độc chì là một tình trạng y tế gây ra bởi nồng độ chì tăng cao trong cơ thể. Chì can thiệp vào nhiều quá trình trong ...... hiện toàn bộ
#ngộ độc chì #hệ thần kinh #phát triển trẻ em #hành vi trẻ em #trí tuệ trẻ em
Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based modelTheoretical Biology and Medical Modelling - Tập 11 - Trang 1-23 - 2014
Abhineet Uppal, Sean C Wightman, Sabha Ganai, Ralph R Weichselbaum, Gary An
Metastatic tumors are a major source of morbidity and mortality for most cancers. Interaction of circulating tumor cells with endothelium, platelets and neutrophils play an important role in the early stages of metastasis formation. These complex dynamics have proven difficult to study in experimental models. Prior computational models of metastases have focused on tumor cell growth in a host envi...... hiện toàn bộ