A clinical study of the effects of lead poisoning on the intelligence and neurobehavioral abilities of children
Tóm tắt
Lead is a heavy metal and important environmental toxicant and nerve poison that can destruction many functions of the nervous system. Lead poisoning is a medical condition caused by increased levels of lead in the body. Lead interferes with a variety of body processes and is toxic to many organs and issues, including the central nervous system. It interferes with the development of the nervous system, and is therefore particularly toxic to children, causing potentially permanent neural and cognitive impairments. In this study, we investigated the relationship between lead poisoning and the intellectual and neurobehavioral capabilities of children.
The background characteristics of the research subjects were collected by questionnaire survey. Blood lead levels were detected by differential potentiometric stripping analysis (DPSA). Intelligence was assessed using the Gesell Developmental Scale. The Achenbach Child Behavior Checklist (CBCL) was used to evaluate each child’s behavior.
Blood lead levels were significantly negatively correlated with the developmental quotients of adaptive behavior, gross motor performance, fine motor performance, language development, and individual social behavior (
Lead poisoning has adverse effects on the behavior and mental development of 2–4-year-old children, prescribing positive and effective precautionary measures.
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Tài liệu tham khảo
Zheng H, Lin WX, Hu HY, Huang JH, Huang MN, He YS: Effects of low-level Lead exposure on the neurobehavioral development of infants and early intervention. Zhonghua Yu Fang Yi Xue Za Zhi. 2008, 42 (3): 165-168.
Shen X, Wu S, Yan C: Impacts of low-level Lead exposure on development of children: recent studies in China. Clin Chim Acta. 2001, 313 (1–2): 217-20.
Carlisle JC, Dowling KC, Siegel DM, Alexeeff GV: A blood Lead benchmark for assessing risks from childhood Lead exposure. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009, 44 (12): 1200-8. 10.1080/10934520903139829.
Cleveland LM, Minter ML, Cobb KA, Scott AA, German VF: Lead hazards for pregnant women and children: part 2: more can still be done to reduce the chance of exposure to Lead in at-risk populations. Am J Nurs. 2008, 108 (11): 40-47. 10.1097/01.NAJ.0000339156.09233.de. quiz 47–8
Ferguson A, Bursac Z, Kern DF: Arkansas People Participating in Lead Education (APPLE): results of a Lead-safe training program. J Community Health. 2011, 36 (3): 367-374. 10.1007/s10900-010-9317-7.
Xu J, Yan CH, Yang B, Xie HF, Zou XY, Zhong L, Gao Y, Tian Y, Shen XM: The role of metabotropic glutamate receptor 5 in developmental Lead neurotoxicity. Toxicol Lett. 2009, 191 (2–3): 223-530.
Kasten-Jolly J, Heo Y, Lawrence DA: Central nervous system cytokine gene expression: modulation by lead. J Biochem Mol Toxicol. 2011, 25 (1): 41-54. 10.1002/jbt.20358.
Olympio KP, Gonçalves C, Günther WM, Bechara EJ: Neurotoxicity and aggressiveness triggered by low-level Lead in children: a review. Rev Panam Salud Publica. 2009, 26 (3): 266-275.
Chen A, Dietrich KN, Ware JH, Radcliffe J, Roqan WJ: IQ and blood Lead from 2 to 7 years of age: are the effects in older children the residual of high blood Lead concentrations in 2-year-olds?. Environ Health Perspect. 2005, 113 (5): 597-601. 10.1289/ehp.7625.
Ames LB: Arnold Gesell: Themes of His Work. 1989, New York: Human Sciences Press
Achenbach TM: Manual for the Child Behavior Checklist/4-18 and 1991 Profile. 1991, Burlington. VT: University of Vermont, Department of Psychiatry
Achenbach TM: Manual for the Teacher's Report form and 1991 Profile. 1991, Burllington, VT: University of Vermont, Department of Psychiatry
Achenbach TM: “Behavior problems in 5- to 11-year-old children from low-income families”: of norms and cutoffs. J Am Acad Child Adolesc Psychiatry. 1995, 34: 536-537. 10.1097/00004583-199505000-00003.
Achenbach TM, Howell CT: Are American children’s problems getting worse? A 13-year comparison. J Am Acad Child Adolesc Psychiatry. 1993, 32: 1145-1154. 10.1097/00004583-199311000-00006.
Raadal M, Milgrom P, Cauce AM, Mancl L: Behavior problems in 5- to 11-year-old children from low-income families. J Am Acad Child Adolesc Psychiatry. 1994, 33: 1017-1025. 10.1097/00004583-199409000-00013.
Cohen LG, Spenciner LJ: Assessment of Young Children. 1994, New York: Longman
Ray TK, Laskar AR: Lead intoxication in children: a global concern. Natl Med J India. 2004, 17 (6): 320-321.
Bellinger D, Leviton A, Waternaux C, Needleman H, Rabinowitz M: Longitudinal analyses of prenatal and postnatal Lead exposure and early cognitive development. N Eng J Med. 1987, 316 (17): 1037-43. 10.1056/NEJM198704233161701.
Oszlánczi G, Papp A, Szabó A, Nagymajtényi L, Sápi A, Kónya Z, Paulik E, Vezér T: Nervous system effects in rats on subacute exposure by Lead-containing nanoparticles via the airways. Inhal Toxicol. 2011, 23 (4): 173-181. 10.3109/08958378.2011.553248.
Burke MG, Miller MD: Practical guidelines for evaluating Lead exposure in children with mental health conditions: molecular effects and clinical implications. Postgrad Med. 2011, 123 (1): 160-168. 10.3810/pgm.2011.01.2256.
Schnaas L, Rothenberg SJ, Perroni E, Martínez S, Hernández C, Hernández RM: Temporal pattern in the effect of postnatal blood Lead level on intellectual development of young children. Neurotoxicol Teratol. 2000, 22 (6): 805-810. 10.1016/S0892-0362(00)00101-X.
Bellinger DC, Hu H, Kalaniti K, Thomas N, Rajan P, Sambandam S, Ramaswamy P, Balakrishnan K: A pilot study of blood Lead levels and neurobehavioral function in children living in Chennai, India. Int J Occup Environ Health. 2005, 11 (2): 138-143.
Miranda ML, Kim D, Galeano MA, Paul CJ, Hull AP, Morgan SP: The relationship between carly childhood blood Lead levels and performance on end-of-grade tests. Environ Health Perspect. 2007, 115 (8): 1242-1247. 10.1289/ehp.9994.
Gilbert SG, Weiss B: A rationale for lowering the blood Lead action level from 10 to 2 microg/dL. Neurotoxicology. 2006, 27 (5): 693-701. 10.1016/j.neuro.2006.06.008.
Mendelsohn AL, Dreyer BP, Fierman AH, Rosen CM, Legano LA, Kruger HA, Lim SW, Courtlandt CD: Low-level Lead exposure and behavior in early childhood. Pediatrics. 1998, 101 (3): E10-10.1542/peds.101.3.e10.
Lewendon G, Kinra S, Nelder R, Cronin T: Should children with developmental and behavioural problems be routinely screened for Lead?. Arch Dis Child. 2001, 85 (4): 286-288. 10.1136/adc.85.4.286.
Mendola P, Selevan SG, Gutter S, Rice D: Environmental factors associated with a sperctrum of neurodevelopmental deficits. Ment Retard Dev Disabil Res Rev. 2002, 8 (3): 188-197. 10.1002/mrdd.10033.
Nevin R: How Lead exposure relates to temporal changes in IQ, violent crime, and unwed pregnancy. Environ Res. 2000, 83 (1): 1-22. 10.1006/enrs.1999.4045.
Dietrich KN, Ris MD, Succop PA, Berger OG, Bornschein RL: Early exposure to Lead and juvenile delinquency. Neurotoxicol Teratol. 2001, 23 (6): 511-518. 10.1016/S0892-0362(01)00184-2.
Needleman HL, McFarland C, Ness RB, Fienberg SE, Tobin MJ: Bone Lead levels in adjucated delinquents A case control study. Neurotoxicol Teratol. 2002, 24 (6): 711-717. 10.1016/S0892-0362(02)00269-6.
Olympio KP, Oliveira PV, Naozuka J, Cardoso MR, Marques AF, Günther WM, Bechara EJ: Surface dental enamel Lead levels and antisocial behavior in Brazilian adolescents. Neurotoxicol Teratol. 2010, 32 (2): 273-279. 10.1016/j.ntt.2009.12.003.
Yeoh B, Woolfenden S, Wheeler D, Alperstein G, Lanphear B: Household interventions for prevention of domestic Lead exposure in children. Cochrane Database Syst Rev. 2008, 16 (2): CD006047-
Marchetti C: Molecular targets of Lead in brain neurotoxicity. Neurotox Res. 2003, 5 (3): 221-236. 10.1007/BF03033142.
Heath LM, Soole KL, McLaughlin ML, McEwan GT, Edwards JW: Toxicity of environmental Lead and the influence of intestinal absorption in children. Rev Environ Health. 2003, 18 (4): 231-50.