Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca2+-enhanced adipogenesis in bone marrow stromal cellsThe Journal of Physiological Sciences - Tập 69 - Trang 741-748 - 2019
Ryota Hashimoto, Yuki Miyamoto, Seigo Itoh, Hiroyuki Daida, Takao Okada, Youichi Katoh
We have previously reported that increased extracellular and intracellular Ca2+ lead to adipocyte accumulation in bone marrow stromal cells (BMSCs). However, strategies to suppress high Ca2+-enhanced adipocyte accumulation have not been reported. We examined the effects of the diacylglycerol analog phorbol 12-myristate 13-acetate (PMA) on proliferation and adipogenesis of mouse primary BMSCs. We u...... hiện toàn bộ
Febuxostat ameliorates muscle degeneration and movement disorder of the dystrophin mutant model in Caenorhabditis elegansThe Journal of Physiological Sciences - Tập 73 - Trang 1-9 - 2023
Sawako Yoshina, Luna Izuhara, Rei Mashima, Yuka Maejima, Naoyuki Kamatani, Shohei Mitani
Duchenne muscular dystrophy (DMD) is an inherited disorder with mutations in the dystrophin gene characterized by progressive muscle degeneration and weakness. Therapy such as administration of glucocorticoids, exon skipping of mutant genes and introduction of dystrophin mini-genes have been tried, but there is no radical therapy for DMD. In this study, we used C. elegans carrying mutations in the...... hiện toàn bộ
Effects of chronic Porphyromonas gingivalis lipopolysaccharide infusion on skeletal muscles in miceThe Journal of Physiological Sciences - Tập 69 - Trang 503-511 - 2019
Naoya Kawamura, Yoshiki Ohnuki, Ichiro Matsuo, Kenji Suita, Misao Ishikawa, Yasumasa Mototani, Kouichi Shiozawa, Aiko Ito, Yuka Yagisawa, Yoshio Hayakawa, Megumi Nariyama, Daisuke Umeki, Yuko Ujiie, Kazuhiro Gomi, Satoshi Okumura
Periodontitis, which is caused by various oral organisms, predominantly affects adults, and is one of the main causes of tooth loss, as well as leading to progression of numerous systemic diseases. However, its relationship to sarcopenia (aging-associated degenerative loss of skeletal muscle mass and function) remains unclear. The aim of this study was to investigate the effects of Porphyromonas g...... hiện toàn bộ
Correlations between “hie-sho” interview score and progesterone, fat intake, and Kupperman index in pre- and post-menopausal women: a pilot studyThe Journal of Physiological Sciences - Tập 69 - Trang 673-681 - 2019
Yuki Uchida, Kyoko Ueshima, Koko Kano, Mayuko Minami, Yuri Mizukami, Keiko Morimoto
Japanese menopausal women who feel cold, even in a warm room, are said to be experiencing “hie-sho.” We assessed the magnitude of coldness by a “hie-sho” interview score. The association between the magnitude of coldness and female hormones, fat intake, and menopausal symptoms is unknown. The aim of the present study was to elucidate the relationship between the hie-sho interview scores and female...... hiện toàn bộ
Erratum to: An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solutionThe Journal of Physiological Sciences - Tập 68 - Trang 101-101 - 2017
Hiroshi Hibino, Madoka Takai, Hidenori Noguchi, Seishiro Sawamura, Yasufumi Takahashi, Hideki Sakai, Hitoshi Shiku
The article An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solution, written by Hiroshi Hibino, Madoka Takai, Hidenori Noguchi, Seishiro Sawamura, Yasufumi Takahashi, Hideki Sakai and Hitoshi Shiku, was originally published Online First without open access.
Non-genomic regulation and disruption of spermatozoal in vitro hyperactivation by oviductal hormonesThe Journal of Physiological Sciences - Tập 66 - Trang 207-212 - 2015
Masakatsu Fujinoki, Gen L. Takei, Hiroe Kon
During capacitation, motility of mammalian spermatozoon is changed from a state of “activation” to “hyperactivation.” Recently, it has been suggested that some hormones present in the oviduct are involved in the regulation of this hyperactivation in vitro. Progesterone, melatonin, and serotonin enhance hyperactivation through specific membrane receptors, and 17β-estradiol suppresses this enhanceme...... hiện toàn bộ