The Journal of Physiological Sciences
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Systematical analysis of impacts of heat stress on the proliferation, apoptosis and metabolism of mouse hepatocyte
The Journal of Physiological Sciences - Tập 62 - Trang 29-43 - 2011
Heat stress will stimulate cells of living organisms to generate heat shock proteins (Hsps). In the mouse liver, impacts of heat stress on hepatocyte proliferation, apoptosis and metabolism have not been studied systematically at different temperatures. In this research, the test mice were heated to 40, 42, 44 and 46°C, respectively, for 20 min and recovered at room temperature for 8 h in normal f...... hiện toàn bộ
Acupuncture attenuates the development of diabetic peripheral neuralgia by regulating P2X4 expression and inflammation in rat spinal microglia
The Journal of Physiological Sciences - Tập 70 - Trang 1-10 - 2020
Diabetic peripheral neuropathy (DPN) is a chronic microvascular complication of diabetes. The purpose of this study is to find the underlying mechanism for the effects of acupuncture in DPN rats. Rats were rendered diabetic with a single injection of 35 mg/kg streptozotocin (STZ). These STZ-diabetic rats were treated with acupuncture for 20 min once daily. The therapeutic efficacy of acupuncture w...... hiện toàn bộ
Assessment of the septal area neuronal activity during penile erections in rapid eye movement sleep and waking in the rats
The Journal of Physiological Sciences - Tập 68 - Trang 567-577 - 2017
To understand the central mechanism of penile erections during rapid eye movement (REM) sleep and waking, single units were recorded from the septal area in un-anesthetized head-restrained rats simultaneous with erections. Erectile events were assessed by pressure in the bulb of the corpus spongiosum of the penis and bulbospongiosus-muscle activity. Of 143 recorded neurons, 36% showed increased ac...... hiện toàn bộ
High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats
The Journal of Physiological Sciences - Tập 73 - Trang 1-10 - 2023
High-intensity interval training (HIIT) is a physical therapy that may benefit patients with osteoarthritis (OA). Cacna2d1 is a calcium channel subunit protein that plays an important role in the activity of nerve cells. However, there is currently no evidence on HIIT relieving OA-associate hyperalgesia by decreased Cacna2d1. Our study established the OA rat models with intra-articular injection o...... hiện toàn bộ
Mechanisms of the TGF-β1/Smad3-signaling pathway in gender differences in alcoholic liver fibrosisAbstract The TGF-β1/Smad3-signaling pathway and gender differences were investigated in alcoholic liver fibrosis. Mice were divided into female normal, female model, male normal, and male model groups. Liver injury and fibrosis were assessed using histopathology and serology. Western blotting was performed to analyze the expression of relevant factors. HSC-T6 cells ... ... hiện toàn bộ
The Journal of Physiological Sciences - Tập 74 Số 1
Gastric acid secretion in cholecystokinin-1 receptor, -2 receptor, and -1, -2 receptor gene knockout mice
The Journal of Physiological Sciences - Tập 59 - Trang 23-29 - 2008
Gastrin is important for stimulating acid secretion as well as differentiating gastric mucosal cells via cholecystokinin-2 receptors (CCK-2Rs). In turn, CCK acts preferably via CCK-1R to release somatostatin, and somatostatin has been postulated to exhibit a tonic inhibition of gastrin bioactivity. The present study was designed to examine the hypothesis that CCK-1R and 2R may act in opposite dire...... hiện toàn bộ
Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats
The Journal of Physiological Sciences - Tập 73 - Trang 1-8 - 2023
In our previous research, we had demonstrated the crucial role of neuronal nicotinic acetylcholine receptors (nAChRs) in potentiation of the olfactory bulb blood flow response to olfactory stimulation in adult rats. The present study examined the effects of nAChR activation on the olfactory bulb blood flow response in rats aged 24–27 months. We found that, under urethane anesthesia, unilateral olf...... hiện toàn bộ
Physiological significance of delayed rectifier K+ channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease
The Journal of Physiological Sciences - Tập 65 - Trang 25-35 - 2014
T lymphocytes predominantly express delayed rectifier K+ channels (Kv1.3) in their plasma membranes. More than 30 years ago, patch-clamp studies revealed that the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. In addition to selective channel inhibitors that have been developed, we recently showed physiological evidence ...... hiện toàn bộ
Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca2+-enhanced adipogenesis in bone marrow stromal cells
The Journal of Physiological Sciences - Tập 69 - Trang 741-748 - 2019
We have previously reported that increased extracellular and intracellular Ca2+ lead to adipocyte accumulation in bone marrow stromal cells (BMSCs). However, strategies to suppress high Ca2+-enhanced adipocyte accumulation have not been reported. We examined the effects of the diacylglycerol analog phorbol 12-myristate 13-acetate (PMA) on proliferation and adipogenesis of mouse primary BMSCs. We u...... hiện toàn bộ
Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism
The Journal of Physiological Sciences - Tập 70 - Trang 1-10 - 2020
Maternal–fetal calcium (Ca2+) transport in the placenta plays a critical role in maintaining fetal bone mineralization. Mutations in the gene encoding the transient receptor potential cation channel, subfamily V, member 6 (TRPV6) have been identified as causative mutations of transient neonatal hyperparathyroidism due to insufficient maternal–fetal Ca2+ transport in the placenta. In this study, we...... hiện toàn bộ
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