β-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxiaThe Journal of Physiological Sciences - Tập 68 - Trang 441-454 - 2017
Klara Hahnova, Iveta Brabcova, Jan Neckar, Romana Weissova, Anna Svatonova, Olga Novakova, Jitka Zurmanova, Martin Kalous, Jan Silhavy, Michal Pravenec, Frantisek Kolar, Jiri Novotny
The β-adrenergic signaling pathways and antioxidant defence mechanisms play important roles in maintaining proper heart function. Here, we examined the effect of chronic normobaric hypoxia (CNH, 10% O2, 3 weeks) on myocardial β-adrenergic signaling and selected components of the antioxidant system in spontaneously hypertensive rats (SHR) and in a conplastic SHR-mtBN strain characterized by the sel...... hiện toàn bộ
Chemogenetic activation of endogenous arginine vasopressin exerts anorexigenic effects via central nesfatin-1/NucB2 pathwayThe Journal of Physiological Sciences - Tập 71 Số 1 - 2021
Kenya Sanada, Mitsuhiro Yoshimura, Naofumi Ikeda, Kazuhiko Baba, Haruki Nishimura, Kazuaki Nishimura, Yuki Nonaka, Takashi Maruyama, Tetsu Miyamoto, Masataka Mori, Becky Conway-Campbell, Stafford Lightman, Masaharu Kataoka
AbstractWe examined whether the chemogenetic activation of endogenous arginine vasopressin (AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was previously generated. Saline (1 mL/kg) or clozapine-N-oxide (CNO, 1 mg/mL/kg), an agonist for hM3Dq, was subcutaneously administered in adult male AVP-hM3Dq-mCherry...... hiện toàn bộ
KB-R7943 inhibits Na+-dependent Mg2+ efflux in rat ventricular myocytesThe Journal of Physiological Sciences - Tập 60 - Trang 415-424 - 2010
Michiko Tashiro, Hana Inoue, Masato Konishi
Na+-dependent Mg2+ efflux activity was studied with the fluorescent Mg2+ indicator furaptra in the presence of various potential antagonists known to inhibit other transporters and channels. Among the compounds tested, KB-R7943, an inhibitor of Na+/Ca2+ exchange, most potently inhibited the Na+/Mg2+ exchange with half inhibitory concentrations (IC50) of 21 μM (25°C) and 16 μM (35°C). These IC50 va...... hiện toàn bộ
Development of synchrony between activity patterns of mother–infant pair from 4 to 18 months after birthThe Journal of Physiological Sciences - Tập 61 - Trang 211-216 - 2011
Hirokazu Doi, Mikako Kato, Shota Nishitani, Kazuyuki Shinohara
Motor activities of interacting agents get temporally coordinated to form synchronized actions. Such activity synchrony is observed in several mammalian species and is supposed to play vital roles in human social interactions. Therefore, it has long been proposed that the activity patterns of mother and infant get temporally synchronized. However, few studies to date have empirically investigated ...... hiện toàn bộ
Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptorsThe Journal of Physiological Sciences - Tập 67 - Trang 235-245 - 2016
Mami Noda, AI Kobayashi
Alpha 7 subunits of nicotinic acetylcholine receptors (nAChRs) are expressed in microglia and are involved in the suppression of neuroinflammation. Over the past decade, many reports show beneficial effects of nicotine, though little is known about the mechanism. Here we show that nicotine inhibits lipopolysaccharide (LPS)-induced proton (H+) currents and morphological change by using primary cult...... hiện toàn bộ
Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervationThe Journal of Physiological Sciences - Tập 70 - Trang 1-8 - 2020
Toru Kawada, Yohsuke Hayama, Takuya Nishikawa, Satoru Suehara, Satoshi Sawada, Tetsuo Tanaka, Minako Uenohara, Masaru Sugimachi
Primary acute sympathetic activation (PASA) can increase arterial pressure (AP). Under this situation, the kidneys may receive mutually opposing influences from sympathetic activation: a direct anti-diuretic effect via the renal innervation and pressure diuresis. We examined whether PASA would reduce urine output regardless of the AP elevation. We also examined the impact of renal denervation (RDN...... hiện toàn bộ