The Journal of Physiological Sciences

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Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats
The Journal of Physiological Sciences - Tập 73 - Trang 1-8 - 2023
Kayo Tsuzawa, Hiroshi Onimaru, Katsunori Inagaki, Masahiko Izumizaki
A metabolite of acetaminophen, AM404, which is an anandamide transporter inhibitor, induces analgesia mainly via activation of transient receptor potential channel 1 in the spinal cord, although the role of cannabinoid receptors remains to be studied. The ventral root reflex response induced by stimulation of the dorsal root in in vitro preparations of rat spinal cord is useful to assess the effec... hiện toàn bộ
β-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia
The Journal of Physiological Sciences - Tập 68 - Trang 441-454 - 2017
Klara Hahnova, Iveta Brabcova, Jan Neckar, Romana Weissova, Anna Svatonova, Olga Novakova, Jitka Zurmanova, Martin Kalous, Jan Silhavy, Michal Pravenec, Frantisek Kolar, Jiri Novotny
The β-adrenergic signaling pathways and antioxidant defence mechanisms play important roles in maintaining proper heart function. Here, we examined the effect of chronic normobaric hypoxia (CNH, 10% O2, 3 weeks) on myocardial β-adrenergic signaling and selected components of the antioxidant system in spontaneously hypertensive rats (SHR) and in a conplastic SHR-mtBN strain characterized by the sel... hiện toàn bộ
Chemogenetic activation of endogenous arginine vasopressin exerts anorexigenic effects via central nesfatin-1/NucB2 pathway
The Journal of Physiological Sciences - Tập 71 Số 1 - 2021
Kenya Sanada, Mitsuhiro Yoshimura, Naofumi Ikeda, Kazuhiko Baba, Haruki Nishimura, Kazuaki Nishimura, Yuki Nonaka, Takashi Maruyama, Tetsu Miyamoto, Masataka Mori, Becky Conway-Campbell, Stafford Lightman, Masaharu Kataoka
AbstractWe examined whether the chemogenetic activation of endogenous arginine vasopressin (AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was previously generated. Saline (1 mL/kg) or clozapine-N-oxide (CNO, 1 mg/mL/kg), an agonist for hM3Dq, was subcutaneously administered in adult male AVP-hM3Dq-mCherry transgenic rats (300–370 g). Food and water intake were sig... hiện toàn bộ
Electrical stimulation of the mesencephalic ventral tegmental area evokes skeletal muscle vasodilatation in the cat and rat
The Journal of Physiological Sciences - Tập 61 - Trang 293-301 - 2011
Kanji Matsukawa, Tomoko Nakamoto, Nan Liang
To test the hypothesis that the mesencephalic ventral tegmental area (VTA) plays a role in autonomic control of the cardiovascular system, we examined the cardiovascular effects of electrical stimulation of the mesencephalic ventral areas in anesthetized, paralyzed cats and rats. Electrical stimulation of the VTA for 30 s (100-μA current intensity; 40–50-Hz pulse frequency; 0.5–1-ms pulse duration... hiện toàn bộ
KB-R7943 inhibits Na+-dependent Mg2+ efflux in rat ventricular myocytes
The Journal of Physiological Sciences - Tập 60 - Trang 415-424 - 2010
Michiko Tashiro, Hana Inoue, Masato Konishi
Na+-dependent Mg2+ efflux activity was studied with the fluorescent Mg2+ indicator furaptra in the presence of various potential antagonists known to inhibit other transporters and channels. Among the compounds tested, KB-R7943, an inhibitor of Na+/Ca2+ exchange, most potently inhibited the Na+/Mg2+ exchange with half inhibitory concentrations (IC50) of 21 μM (25°C) and 16 μM (35°C). These IC50 va... hiện toàn bộ
Mechanisms underlying the modulation of L-type Ca2+ channel by hydrogen peroxide in guinea pig ventricular myocytes
The Journal of Physiological Sciences - - 2013
Lei Yang, Jianjun Xu, Etsuko Minobe, Lifeng Yu, Rui Feng, Asako Kameyama, Kazuto Yazawa, Masaki Kameyama
Role of Ca2+ in the rapid cooling-induced Ca2+ release from sarcoplasmic reticulum in ferret cardiac muscles
The Journal of Physiological Sciences - Tập 62 Số 3 - Trang 241-250 - 2012
Etsuko Tanaka, Masato Konishi, Satoshi Kurihara
Development of synchrony between activity patterns of mother–infant pair from 4 to 18 months after birth
The Journal of Physiological Sciences - Tập 61 - Trang 211-216 - 2011
Hirokazu Doi, Mikako Kato, Shota Nishitani, Kazuyuki Shinohara
Motor activities of interacting agents get temporally coordinated to form synchronized actions. Such activity synchrony is observed in several mammalian species and is supposed to play vital roles in human social interactions. Therefore, it has long been proposed that the activity patterns of mother and infant get temporally synchronized. However, few studies to date have empirically investigated ... hiện toàn bộ
Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors
The Journal of Physiological Sciences - Tập 67 - Trang 235-245 - 2016
Mami Noda, AI Kobayashi
Alpha 7 subunits of nicotinic acetylcholine receptors (nAChRs) are expressed in microglia and are involved in the suppression of neuroinflammation. Over the past decade, many reports show beneficial effects of nicotine, though little is known about the mechanism. Here we show that nicotine inhibits lipopolysaccharide (LPS)-induced proton (H+) currents and morphological change by using primary cult... hiện toàn bộ
Vitamin E supplementation decreases muscular and oxidative damage but not inflammatory response induced by eccentric contraction
The Journal of Physiological Sciences - Tập 60 Số 1 - 2010
Luciano Acordi da Silva, Cléber A. Pinho, Paulo César Lock Silveira, Talita Tuon, Cláudio Teodoro de Souza, Felipe Dal‐Pizzol, Ricardo Aurino de Pinho
Tổng số: 680   
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