The Journal of Nutritional Biochemistry

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Transcriptome analysis of T cells from Ldlr −/− mice and effects of in vitro vitamin D treatment
The Journal of Nutritional Biochemistry - - Trang 109510 - 2023
Lee Ga Young, Hwang Jungwon, Kwon Deok Hoon, Han Sung Nim, You Hyeyoung, Son YeKyoung
Vitamin D is known for its immunosuppressive effects on T cells, suppressing Th1 and Th17 and promoting Treg differentiation. Th1 cells contribute to inflammatory responses such as inflammatory cytokine production and macrophage activation, which accelerate the progression of atherosclerosis. However, the mechanisms underlying the modulation of T cell functions by vitamin D in atherosclerosis have not been investigated. This study analyzed the gene expression profiles of T cells, using RNA-seq transcriptome analysis, to investigate the effects of in vitro vitamin D treatment on T cell differentiation and signal transduction pathways in Ldlr knock-out (Ldlr −/−) mice. C57BL/6 mice were randomly assigned to two groups and fed a control diet (CON) or a Western diet (WD) for 16 weeks, while Ldlr −/- mice (LDLR−/−) were fed a Western diet. Splenic T cells were isolated and stimulated with anti-CD3e and anti-CD28 mAb for 48 hours with or without 10 nM 1,25(OH)2D3. RNA sequencing was performed, followed by KEGG and GO enrichment analyses. Populations of T cell subsets and cytokine production were measured to assess T cell lineage differentiation. The JAK-STAT, HIF-1, and calcium signaling pathways of Ldlr −/− mice significantly differed from those of control mice, and 1,25(OH)2D3 treatment affected MAPKKK binding molecular function of Ldlr −/− mice. Percentages of Th1 cells and IL-17 production were significantly reduced by 1,25(OH)2D3 treatment in all three mouse groups. These results suggest that 1,25(OH)2D3 has anti-inflammatory effects in atherosclerosis and is involved in cell signaling pathways that could prevent disease progression by regulating T cell differentiation and effector functions.
#Atherosclerosis #vitamin D #T cell #transcriptome analysis #signaling pathway
Iron supplementation and iron status in exercising young women
The Journal of Nutritional Biochemistry - Tập 2 - Trang 368-373 - 1991
Christine A. Jensen, Connie M. Weaver, Darlene A. Sedlock
Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties
The Journal of Nutritional Biochemistry - Tập 23 - Trang 1249-1255 - 2012
Nari Yun, Jung-Woo Kang, Sun-Mee Lee
Effect of a cocoa-enriched diet on immune response and anaphylaxis in a food allergy model in Brown Norway rats
The Journal of Nutritional Biochemistry - Tập 27 - Trang 317-326 - 2016
Mar Abril-Gil, Francisco J. Pérez-Cano, Àngels Franch, Margarida Castell
Adequate but not supplemental folic acid combined with soy isoflavones during early life improves bone health at adulthood in male mice
The Journal of Nutritional Biochemistry - Tập 24 - Trang 1691-1696 - 2013
Jovana Kaludjerovic, Wendy E. Ward
The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children
The Journal of Nutritional Biochemistry - Tập 70 - Trang 38-46 - 2019
Antonio Belardo, Federica Gevi, Lello Zolla
Signal transduction in insulin action
The Journal of Nutritional Biochemistry - Tập 1 - Trang 180-188 - 1990
Alan R. Saltiel
RETRACTED: Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating the Sirt1–AMPK pathway
The Journal of Nutritional Biochemistry - Tập 43 - Trang 88-97 - 2017
Kaiping Wang, Zhuohong Tang, Jinglin Wang, Peng Cao, Qiang Li, Weizhi Shui, Hongjing Wang, Ziming Zheng, Yu Zhang
An ω-3-enriched diet alone does not attenuate CCl 4 -induced hepatic fibrosis
The Journal of Nutritional Biochemistry - Tập 38 - Trang 93-101 - 2016
Todd R. Harris, Sean Kodani, Jun Yang, Denise M. Imai, Bruce D. Hammock
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