The Journal of Nutritional Biochemistry
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Dietary conjugated linoleic acid alters long chain polyunsaturated fatty acid metabolism in brain and liver of neonatal pigs
The Journal of Nutritional Biochemistry - Tập 22 - Trang 1047-1054 - 2011
Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients
The Journal of Nutritional Biochemistry - Tập 7 - Trang 659-663 - 1996
Dietary modulation of mitochondrial DNA damage: implications in aging and associated diseases
The Journal of Nutritional Biochemistry - Tập 63 - Trang 1-10 - 2019
Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats
The Journal of Nutritional Biochemistry - Tập 17 - Trang 282-289 - 2006
Ferulic acid, a bioactive component of rice bran, improves oxidative stress and mitochondrial biogenesis and dynamics in mice and in human mononuclear cells
The Journal of Nutritional Biochemistry - Tập 48 - Trang 51-61 - 2017
Modulating Role of Dietary Fat, Energy Restriction, and the Effect of Age on the Expression of Proliferating Cell Nuclear Antigen and Protein Kinase C Activity in Prostate Glands of Rats
The Journal of Nutritional Biochemistry - Tập 9 - Trang 236-241 - 1998
Transcriptome analysis of T cells from Ldlr −/− mice and effects of in vitro vitamin D treatment
The Journal of Nutritional Biochemistry - - Trang 109510 - 2023
Vitamin D is known for its immunosuppressive effects on T cells, suppressing Th1 and Th17 and promoting Treg differentiation. Th1 cells contribute to inflammatory responses such as inflammatory cytokine production and macrophage activation, which accelerate the progression of atherosclerosis. However, the mechanisms underlying the modulation of T cell functions by vitamin D in atherosclerosis have not been investigated. This study analyzed the gene expression profiles of T cells, using RNA-seq transcriptome analysis, to investigate the effects of in vitro vitamin D treatment on T cell differentiation and signal transduction pathways in Ldlr knock-out (Ldlr −/−) mice. C57BL/6 mice were randomly assigned to two groups and fed a control diet (CON) or a Western diet (WD) for 16 weeks, while Ldlr −/- mice (LDLR−/−) were fed a Western diet. Splenic T cells were isolated and stimulated with anti-CD3e and anti-CD28 mAb for 48 hours with or without 10 nM 1,25(OH)2D3. RNA sequencing was performed, followed by KEGG and GO enrichment analyses. Populations of T cell subsets and cytokine production were measured to assess T cell lineage differentiation. The JAK-STAT, HIF-1, and calcium signaling pathways of Ldlr −/− mice significantly differed from those of control mice, and 1,25(OH)2D3 treatment affected MAPKKK binding molecular function of Ldlr −/− mice. Percentages of Th1 cells and IL-17 production were significantly reduced by 1,25(OH)2D3 treatment in all three mouse groups. These results suggest that 1,25(OH)2D3 has anti-inflammatory effects in atherosclerosis and is involved in cell signaling pathways that could prevent disease progression by regulating T cell differentiation and effector functions.
#Atherosclerosis #vitamin D #T cell #transcriptome analysis #signaling pathway
Iron supplementation and iron status in exercising young women
The Journal of Nutritional Biochemistry - Tập 2 - Trang 368-373 - 1991
Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: molecular evidence of its antioxidant and anti-inflammatory properties
The Journal of Nutritional Biochemistry - Tập 23 - Trang 1249-1255 - 2012
Effect of a cocoa-enriched diet on immune response and anaphylaxis in a food allergy model in Brown Norway rats
The Journal of Nutritional Biochemistry - Tập 27 - Trang 317-326 - 2016
Tổng số: 2,209
- 1
- 2
- 3
- 4
- 5
- 6
- 10