The activity comparison of six dietary flavonoids identifies that luteolin inhibits 3T3-L1 adipocyte differentiation through reducing ROS generation

Haider, 2019, Harnessing adipogenesis to prevent obesity, Adipocyte, 8, 98, 10.1080/21623945.2019.1583037 Spiegelman, 2001, Obesity and the regulation of energy balance, Cell, 104, 531, 10.1016/S0092-8674(01)00240-9 Shin, 2020, Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes, Redox Biol, 37, 10.1016/j.redox.2020.101749 Avram, 2007, Subcutaneous fat in normal and diseased states 3. Adipogenesis: from stem cell to fat cell, J Am Acad Dermatol, 56, 472, 10.1016/j.jaad.2006.06.022 Vishvanath, 2019, Contribution of adipogenesis to healthy adipose tissue expansion in obesity, J Clin Invest, 129, 4022, 10.1172/JCI129191 Navab, 2008, Inflammation and metabolic disorders, Curr Opin Clin Nutr Metab Care, 11, 45964, 10.1097/MCO.0b013e32830460c2 Atashi, 2015, The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review, Stem Cells Dev, 24, 1150, 10.1089/scd.2014.0484 Lee, 2009, Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion, J Biol Chem, 284, 10601, 10.1074/jbc.M808742200 Tormos, 2011, Mitochondrial complex III ROS regulate adipocyte differentiation, Cell Metab, 14, 537, 10.1016/j.cmet.2011.08.007 Huh, 2012, Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression, Antioxid Redox Signal, 16, 229, 10.1089/ars.2010.3766 Kim, 2018, Peroxiredoxin 5 regulates adipogenesis-attenuating oxidative stress in obese mouse models induced by a high-fat diet, Free Radic Biol Med, 123, 27, 10.1016/j.freeradbiomed.2018.05.061 Kalyanaraman, 2013, Teaching the basics of redox biology to medical and graduate students: oxidants, antioxidants and disease mechanisms, Redox Biol, 1, 244, 10.1016/j.redox.2013.01.014 Khalilpourfarshbafi, 2019, Differential effects of dietary flavonoids on adipogenesis, Eur J Nutr, 58, 5, 10.1007/s00394-018-1663-8 Ross, 2002, Dietary flavonoids: bioavailability, metabolic effects, and safety, Annu Rev Nutr, 22, 19, 10.1146/annurev.nutr.22.111401.144957 Wang, 2018, Bioactive flavonoids in medicinal plants: structure, activity and biological fate, Asian J Pharm Sci, 13, 12, 10.1016/j.ajps.2017.08.004 Mosqueda-Solís, 2017, Screening of potential anti-adipogenic effects of phenolic compounds showing different chemical structure in 3T3-L1 preadipocytes, Food Funct, 8, 3576, 10.1039/C7FO00679A Lin, 2020, Luteolin reduces fat storage in Caenorhabditis elegans by promoting the central serotonin pathway, Food Funct, 11, 730, 10.1039/C9FO02095K Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, 65, 55, 10.1016/0022-1759(83)90303-4 Zhang, 2016, Dietary luteolin activates browning and thermogenesis in mice through an AMPK/PGC1α pathway-mediated mechanism, Int J Obes (Lond), 40, 10.1038/ijo.2016.108 Cristancho, 2011, Forming functional fat: a growing understanding of adipocyte differentiation, Nat Rev Mol Cell Biol, 12, 722, 10.1038/nrm3198 Chen, 2021, Adipose-specific BMP and activin membrane-bound inhibitor (BAMBI) deletion promotes adipogenesis by accelerating ROS production, J Biol Chem, 296, 10.1074/jbc.RA120.014793 Vinogradov, 2016, Oxidation of NADH and ROS production by respiratory complex I, Biochim Biophys Acta, 1857, 86371 Gentile, 2018, Luteolin prevents cardiometabolic alterations and vascular dysfunction in mice with HFD-induced obesity, Front Pharmacol, 9, 1094, 10.3389/fphar.2018.01094 Su, 2016, Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice, J Zhejiang Univ Sci B, 17, 437, 10.1631/jzus.B1600074 Tan, 2021, Quercetin ameliorates insulin resistance and restores gut microbiome in mice on high-fat diets, Antioxidants (Basel), 10, 1251, 10.3390/antiox10081251 Wang, 2020, Preventive effects of kaempferol on high-fat diet-induced obesity complications in C57BL/6 Mice, Biomed Res Int, 2020 Wang, 2021, Chrysin stimulates subcutaneous fat thermogenesis in mice by regulating PDGFRα and MicroRNA expressions, J Agric Food Chem, 69, 5897, 10.1021/acs.jafc.1c01130 Wu, 2021, Apigenin ameliorates insulin resistance and lipid accumulation by endoplasmic reticulum stress and SREBP-1c/SREBP-2 pathway in palmitate-induced HepG2 cells and high-fat diet-fed mice, J Pharmacol Exp Ther, 377, 146, 10.1124/jpet.120.000162 Li, 2020, Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway, Biomed Pharmacother, 131, 10.1016/j.biopha.2020.110769 Guru, 2021, Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds, Mol Biol Rep, 48, 743, 10.1007/s11033-020-06036-8 Tang, 2003, CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis, Proc Natl Acad Sci, 100, 850, 10.1073/pnas.0337434100 Tsai, 2020, Effect of astaxanthin on the inhibition of lipid accumulation in 3T3-L1 adipocytes via modulation of lipogenesis and fatty acid transport pathways, Molecules, 25, 3598, 10.3390/molecules25163598 Hu, 1996, AdipoQ is a novel adipose-specific gene dysregulated in obesity, J Biol Chem, 271, 10697, 10.1074/jbc.271.18.10697 Klein, 1996, Adipose tissue leptin production and plasma leptin kinetics in humans, Diabetes, 45, 984, 10.2337/diab.45.7.984 de Villiers, 2018, The role of reactive oxygen species in adipogenic differentiation, Adv Exp Med Biol, 1083, 125, 10.1007/5584_2017_119 Calzadilla, 2011, N-acetylcysteine reduces markers of differentiation in 3T3-L1 adipocytes, Int J Mol Sci, 12, 6936, 10.3390/ijms12106936 Çelik, 2012, Inhibitory effects of dietary flavonoids on purified hepatic NADH-cytochrome b5 reductase: structure-activity relationships, Chem Biol Interact, 197, 103, 10.1016/j.cbi.2012.04.003 Arora, 1998, Structure-activity relationships for antioxidant activities of a series of flavonoids in a liposomal system, Free Radic Biol Med, 24, 10.1016/S0891-5849(97)00458-9 Ribeiro, 2014, Inhibition of LOX by flavonoids: a structure-activity relationship study, Eur J Med Chem, 72, 137, 10.1016/j.ejmech.2013.11.030 Poudel, 2015, Flavonoids from Triticum aestivum inhibit adipogenesis in 3T3-L1 cells by upregulating the insig pathway, Mol Med Rep, 12, 3139, 10.3892/mmr.2015.3700 Kwon, 2016, Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of dnaJ (Hsp40) homolog, subfamily B, Member 1, J Nutr Biochem, 30, 24, 10.1016/j.jnutbio.2015.11.013