Stem Cells

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Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
Stem Cells - Tập 27 Số 9 - Trang 2059-2068 - 2009
Nawneet K. Kurrey, Swati Jalgaonkar, Archis Joglekar, Avinash Ghanate, Prasad Chaskar, Rahul Y. Doiphode, Sharmila A. Bapat
Abstract The transcriptional repressors Snail and Slug contribute to cancer progression by mediating epithelial-mesenchymal transition (EMT), which results in tumor cell invasion and metastases. We extend this current understanding to demonstrate their involvement in the development of resistance to radiation and paclitaxel. The process is orchestrat...... hiện toàn bộ
Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
Stem Cells - Tập 28 Số 10 - Trang 1728-1740 - 2010
Aba Somers, Jyh‐Chang Jean, Cesar Sommer, Amel Omari, Christopher Ford, Jason A. Mills, Lei Ying, Andreia Gianotti Sommer, Brenden W. Smith, Robert Lafyatis, George Kroumpouzos, Daniel C. Chambers, Deborah L. French, Paul Gadue, George J. Murphy, Gustavo Mostoslavsky, Darrell N. Kotton
Abstract The development of methods to achieve efficient reprogramming of human cells while avoiding the permanent presence of reprogramming transgenes represents a critical step toward the use of induced pluripotent stem cells (iPSC) for clinical purposes, such as disease modeling or reconstituting therapies. Although several methods exist for gener...... hiện toàn bộ
Recombinant Vitronectin Is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-Renewal via αVβ5 Integrin
Stem Cells - Tập 26 Số 9 - Trang 2257-2265 - 2008
Stefan Braam, Laura Zeinstra, Sandy H.M. Litjens, Dorien Ward‐van Oostwaard, Stieneke van den Brink, Linda van Laake, Franck Lebrin, Peter Kats, Ron Hochstenbach, Robert Passier, Arnoud Sonnenberg, Christine L. Mummery
AbstractDefined growth conditions are essential for many applications of human embryonic stem cells (hESC). Most defined media are presently used in combination with Matrigel, a partially defined extracellular matrix (ECM) extract from mouse sarcoma. Here, we defined ECM requirements of hESC by analyzing integrin expression and ECM production and determined integri...... hiện toàn bộ
Polycistronic Lentiviral Vector for “Hit and Run” Reprogramming of Adult Skin Fibroblasts to Induced Pluripotent Stem Cells
Stem Cells - Tập 27 Số 5 - Trang 1042-1049 - 2009
Chia‐Wei Chang, Yi-Shin Lai, Kevin M. Pawlik, Kaimao Liu, Chengzhen Sun, Chao Li, Trenton R. Schoeb, Tim M. Townes
Abstract We report the derivation of induced pluripotent stem (iPS) cells from adult skin fibroblasts using a single, polycistronic lentiviral vector encoding the reprogramming factors Oct4, Sox2, and Klf4. Porcine teschovirus-1 2A sequences that trigger ribosome skipping were inserted between human cDNAs for these factors, and the polycistron was su...... hiện toàn bộ
Laminin-511 but Not -332, -111, or -411 Enables Mouse Embryonic Stem Cell Self-Renewal In Vitro
Stem Cells - Tập 26 Số 11 - Trang 2800-2809 - 2008
Anna Domogatskaya, Sergey Rodin, Ariel Boutaud, Karl Tryggvason
Abstract We tested specific laminin (LN) isoforms for their ability to serve as substrata for maintaining mouse embryonic stem (ES) cells pluripotent in vitro in the absence of leukemia inhibitory factor or any other differentiation inhibitors or feeder cells. Recombinant human LN-511 alone was sufficient to enable self-renewal of mouse ES cells for ...... hiện toàn bộ
High-Efficiency Induction of Neural Conversion in Human ESCs and Human Induced Pluripotent Stem Cells with a Single Chemical Inhibitor of Transforming Growth Factor Beta Superfamily Receptors
Stem Cells - Tập 28 Số 10 - Trang 1741-1750 - 2010
Jiaxi Zhou, Pei Su, Dong Li, Stephanie Jean Tsang, Enkui Duan, Neven Duić
Abstract Chemical compounds have emerged as powerful tools for modulating ESC functions and deriving induced pluripotent stem cells (iPSCs), but documentation of compound-induced efficient directed differentiation in human ESCs (hESCs) and human iPSC (hiPSCs) is limited. By screening a collection of chemical compounds, we identified compound C (also ...... hiện toàn bộ
BMP4 Promotes EMT and Mesodermal Commitment in Human Embryonic Stem Cells via SLUG and MSX2
Stem Cells - Tập 32 Số 3 - Trang 636-648 - 2014
Anne Richter, Lena Valdimarsdottir, Helga Eyja Hrafnkelsdóttir, Johann Frimann Runarsson, Arna Rún Ómarsdóttir, Dorien Ward‐van Oostwaard, Christine L. Mummery, Guðrún Valdimarsdóttir
AbstractBone morphogenetic proteins (BMPs) initiate differentiation in human embryonic stem cells (hESCs) but the exact mechanisms have not been fully elucidated. We demonstrate here that SLUG and MSX2, transcription factors involved in epithelial–mesenchymal transitions, essential features of gastrulation in development and tumor progression, are important mediato...... hiện toàn bộ
Protection of the Small Intestinal Clonogenic Stem Cells from Radiation‐Induced Damage by Pretreatment with Interleukin 11 also Increases Murine Survival Time
Stem Cells - Tập 14 Số 4 - Trang 452-459 - 1996
C.S. Potten
Functional Differences between Subpopulations of Mobilized Peripheral Blood‐Derived CD34+Cells Expressing Different Levels of HLA‐DR, CD33, CD38 and c‐kit Antigens
Stem Cells - Tập 15 Số 1 - Trang 73-81 - 1997
Hideaki Sakabe, Yoshikazu Ohmizono, Shigeatsu Tanimukai, Takafumi Kimura, Kazuhiro Mori, Tatsuo Abe, Yoshiaki Sonoda
Role and Function of Matrix Metalloproteinases in the Differentiation and Biological Characterization of Mesenchymal Stem Cells
Stem Cells - Tập 24 Số 3 - Trang 475-481 - 2006
Ferdinando Mannello, Gaetana A. Tonti, Gian Paolo Bagnara, Stefano Papa
Abstract Matrix metalloproteinases (MMPs), known as matrixins, are Ca- and Zn-dependent endoproteinases involved in a wide variety of developmental and disease-associated processes, proving to be crucial protagonists in many physiological and pathological mechanisms. The ability of MMPs to alter, by limited proteolysis and through the fine control of...... hiện toàn bộ
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