Stem Cells

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Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
Stem Cells - Tập 28 Số 10 - Trang 1728-1740 - 2010
Aba Somers, Jyh‐Chang Jean, Cesar Sommer, Amel Omari, Christopher Ford, Jason A. Mills, Lei Ying, Andreia Gianotti Sommer, Brenden W. Smith, Robert Lafyatis, George Kroumpouzos, Daniel C. Chambers, Deborah L. French, Paul Gadue, George J. Murphy, Gustavo Mostoslavsky, Darrell N. Kotton
Abstract The development of methods to achieve efficient reprogramming of human cells while avoiding the permanent presence of reprogramming transgenes represents a critical step toward the use of induced pluripotent stem cells (iPSC) for clinical purposes, such as disease modeling or reconstituting therapies. Although several methods exist for gener...... hiện toàn bộ
High-Efficiency Induction of Neural Conversion in Human ESCs and Human Induced Pluripotent Stem Cells with a Single Chemical Inhibitor of Transforming Growth Factor Beta Superfamily Receptors
Stem Cells - Tập 28 Số 10 - Trang 1741-1750 - 2010
Jiaxi Zhou, Pei Su, Dong Li, Stephanie Jean Tsang, Enkui Duan, Neven Duić
Abstract Chemical compounds have emerged as powerful tools for modulating ESC functions and deriving induced pluripotent stem cells (iPSCs), but documentation of compound-induced efficient directed differentiation in human ESCs (hESCs) and human iPSC (hiPSCs) is limited. By screening a collection of chemical compounds, we identified compound C (also ...... hiện toàn bộ
BMP4 Promotes EMT and Mesodermal Commitment in Human Embryonic Stem Cells via SLUG and MSX2
Stem Cells - Tập 32 Số 3 - Trang 636-648 - 2014
Anne Richter, Lena Valdimarsdottir, Helga Eyja Hrafnkelsdóttir, Johann Frimann Runarsson, Arna Rún Ómarsdóttir, Dorien Ward‐van Oostwaard, Christine L. Mummery, Guðrún Valdimarsdóttir
AbstractBone morphogenetic proteins (BMPs) initiate differentiation in human embryonic stem cells (hESCs) but the exact mechanisms have not been fully elucidated. We demonstrate here that SLUG and MSX2, transcription factors involved in epithelial–mesenchymal transitions, essential features of gastrulation in development and tumor progression, are important mediato...... hiện toàn bộ
Functional Differences between Subpopulations of Mobilized Peripheral Blood‐Derived CD34+Cells Expressing Different Levels of HLA‐DR, CD33, CD38 and c‐kit Antigens
Stem Cells - Tập 15 Số 1 - Trang 73-81 - 1997
Hideaki Sakabe, Yoshikazu Ohmizono, Shigeatsu Tanimukai, Takafumi Kimura, Kazuhiro Mori, Tatsuo Abe, Yoshiaki Sonoda
Pluripotent Stem Cell Model Reveals Essential Roles for miR‐450b‐5p and miR‐184 in Embryonic Corneal Lineage Specification
Stem Cells - Tập 30 Số 5 - Trang 898-909 - 2012
Ruby Shalom‐Feuerstein, Laura Serror, Stéphanie de la Forest Divonne, Isabelle Petit, Édith Aberdam, Lívia Cardoso Bueno de Camargo, Odile Damour, Clotilde Vigouroux, Abraham Solomon, Cédric Gaggioli, Joseph Itskovitz‐Eldor, Sajjad Ahmad, Daniel Aberdam
Derivation of Clinically Compliant MSCs from CD105+, CD24− Differentiated Human ESCs
Stem Cells - Tập 25 Số 2 - Trang 425-436 - 2007
Qizhou Lian, Elias Lye, Keng Suan Yeo, Eileen Khia Way Tan, Manuel Salto‐Tellez, Tongming Liu, Nallasivam Palanisamy, Reida El Oakley, Eng Hin Lee, Bing Lim, Sai Kiang Lim
Abstract Adult tissue-derived mesenchymal stem cells (MSCs) have demonstrated therapeutic efficacy in treating diseases or repairing damaged tissues through mechanisms thought to be mediated by either cell replacement or secretion of paracrine factors. Characterized, self-renewing human ESCs could potentially be an invariable source of consistently u...... hiện toàn bộ
Role of MicroRNAs 99b, 181a, and 181b in the Differentiation of Human Embryonic Stem Cells to Vascular Endothelial Cells
Stem Cells - Tập 30 Số 4 - Trang 643-654 - 2012
Nicole M. Kane, Lynsey Howard, B Descamps, Marco Meloni, John McClure, Ruifang Lu, Angela McCahill, Christopher R. Breen, Ruth M. Mackenzie, Christian Delles, Joanne C. Mountford, Graeme Milligan, Costanza Emanueli, Andrew H. Baker
AbstractMicroRNAs (miRNAs) are short noncoding RNAs, which post-transcriptionally regulate gene expression. miRNAs are transcribed as precursors and matured to active forms by a series of enzymes, including Dicer. miRNAs are important in governing cell differentiation, development, and disease. We have recently developed a feeder- and serum-free protocol for direct...... hiện toàn bộ
Human AB Serum and Thrombin-Activated Platelet-Rich Plasma Are Suitable Alternatives to Fetal Calf Serum for the Expansion of Mesenchymal Stem Cells from Adipose Tissue
Stem Cells - Tập 25 Số 5 - Trang 1270-1278 - 2007
Asli Kocaoemer, Susanne Kern, Harald Klüter, Karen Bieback
Abstract MSCs are currently in focus regarding their clinical potential in cell therapy and tissue engineering. However, most isolation and expansion protocols for clinical-scale production of MSCs use fetal calf serum (FCS) as a supplement, which poses a potential risk for infections as well as immunological reactions. To find a suitable FCS substit...... hiện toàn bộ
Concise Review: No Breakthroughs for Human Mesenchymal and Embryonic Stem Cell Culture: Conditioned Medium, Feeder Layer, or Feeder‐Free; Medium with Fetal Calf Serum, Human Serum, or Enriched Plasma; Serum‐Free, Serum Replacement Nonconditioned Medium, or Ad Hoc Formula? All That Glitters Is Not Gold!
Stem Cells - Tập 25 Số 7 - Trang 1603-1609 - 2007
Ferdinando Mannello, Gaetana A. Tonti
Facilitated Expansion of Human Embryonic Stem Cells by Single‐Cell Enzymatic Dissociation
Stem Cells - Tập 25 Số 7 - Trang 1690-1696 - 2007
Catharina Ellerström, Raimund Strehl, Karin Noaksson, Johan Hyllner, Henrik Semb
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