Stem Cells
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
Stem Cells - Tập 27 Số 9 - Trang 2059-2068 - 2009
Abstract The transcriptional repressors Snail and Slug contribute to cancer
progression by mediating epithelial-mesenchymal transition (EMT), which results
in tumor cell invasion and metastases. We extend this current understanding to
demonstrate their involvement in the development of resistance to radiation and
paclitaxel. The process is orchestrated through the acquisition of a novel
subset of ...
Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
Stem Cells - Tập 28 Số 10 - Trang 1728-1740 - 2010
Abstract The development of methods to achieve efficient reprogramming of human
cells while avoiding the permanent presence of reprogramming transgenes
represents a critical step toward the use of induced pluripotent stem cells
(iPSC) for clinical purposes, such as disease modeling or reconstituting
therapies. Although several methods exist for generating iPSC free of
reprogramming transgenes from...
Recombinant Vitronectin Is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-Renewal via αVβ5 Integrin
Stem Cells - Tập 26 Số 9 - Trang 2257-2265 - 2008
AbstractDefined growth conditions are essential for many applications of human
embryonic stem cells (hESC). Most defined media are presently used in
combination with Matrigel, a partially defined extracellular matrix (ECM)
extract from mouse sarcoma. Here, we defined ECM requirements of hESC by
analyzing integrin expression and ECM production and determined integrin
function using blocking antibod...
Polycistronic Lentiviral Vector for “Hit and Run” Reprogramming of Adult Skin Fibroblasts to Induced Pluripotent Stem Cells
Stem Cells - Tập 27 Số 5 - Trang 1042-1049 - 2009
Abstract We report the derivation of induced pluripotent stem (iPS) cells from
adult skin fibroblasts using a single, polycistronic lentiviral vector encoding
the reprogramming factors Oct4, Sox2, and Klf4. Porcine teschovirus-1 2A
sequences that trigger ribosome skipping were inserted between human cDNAs for
these factors, and the polycistron was subcloned downstream of the elongation
factor 1 al...
Laminin-511 but Not -332, -111, or -411 Enables Mouse Embryonic Stem Cell Self-Renewal In Vitro
Stem Cells - Tập 26 Số 11 - Trang 2800-2809 - 2008
Abstract We tested specific laminin (LN) isoforms for their ability to serve as
substrata for maintaining mouse embryonic stem (ES) cells pluripotent in vitro
in the absence of leukemia inhibitory factor or any other differentiation
inhibitors or feeder cells. Recombinant human LN-511 alone was sufficient to
enable self-renewal of mouse ES cells for up to 169 days (31 passages). Cells
cultured on ...
High-Efficiency Induction of Neural Conversion in Human ESCs and Human Induced Pluripotent Stem Cells with a Single Chemical Inhibitor of Transforming Growth Factor Beta Superfamily Receptors
Stem Cells - Tập 28 Số 10 - Trang 1741-1750 - 2010
Abstract Chemical compounds have emerged as powerful tools for modulating ESC
functions and deriving induced pluripotent stem cells (iPSCs), but documentation
of compound-induced efficient directed differentiation in human ESCs (hESCs) and
human iPSC (hiPSCs) is limited. By screening a collection of chemical compounds,
we identified compound C (also denoted as dorsomorphin), a protein kinase
inhib...
BMP4 Promotes EMT and Mesodermal Commitment in Human Embryonic Stem Cells via SLUG and MSX2
Stem Cells - Tập 32 Số 3 - Trang 636-648 - 2014
AbstractBone morphogenetic proteins (BMPs) initiate differentiation in human
embryonic stem cells (hESCs) but the exact mechanisms have not been fully
elucidated. We demonstrate here that SLUG and MSX2, transcription factors
involved in epithelial–mesenchymal transitions, essential features of
gastrulation in development and tumor progression, are important mediators of
BMP4-induced differentiatio...
Protection of the Small Intestinal Clonogenic Stem Cells from Radiation‐Induced Damage by Pretreatment with Interleukin 11 also Increases Murine Survival Time
Stem Cells - Tập 14 Số 4 - Trang 452-459 - 1996
Functional Differences between Subpopulations of Mobilized Peripheral Blood‐Derived CD34+Cells Expressing Different Levels of HLA‐DR, CD33, CD38 and c‐kit Antigens
Stem Cells - Tập 15 Số 1 - Trang 73-81 - 1997
Role and Function of Matrix Metalloproteinases in the Differentiation and Biological Characterization of Mesenchymal Stem Cells
Stem Cells - Tập 24 Số 3 - Trang 475-481 - 2006
Abstract Matrix metalloproteinases (MMPs), known as matrixins, are Ca- and
Zn-dependent endoproteinases involved in a wide variety of developmental and
disease-associated processes, proving to be crucial protagonists in many
physiological and pathological mechanisms. The ability of MMPs to alter, by
limited proteolysis and through the fine control of tissue inhibitors of
metalloproteinases, the ac...
Tổng số: 206
- 1
- 2
- 3
- 4
- 5
- 6
- 10