Role and Function of Matrix Metalloproteinases in the Differentiation and Biological Characterization of Mesenchymal Stem Cells

Stem Cells - Tập 24 Số 3 - Trang 475-481 - 2006
Ferdinando Mannello1, Gaetana A. Tonti1, Gian Paolo Bagnara2,3, Stefano Papa4
1Institute of Histology and Laboratory Analysis, University "Carlo Bo" of Urbino, Urbino, Italy
2Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
3Stem Cell Research Center, University of Bologna, Bologna, Italy
4Institute of Morphological Sciences, Center of Cytometry, University "Carlo Bo" of Urbino, Urbino, Italy

Tóm tắt

Abstract Matrix metalloproteinases (MMPs), known as matrixins, are Ca- and Zn-dependent endoproteinases involved in a wide variety of developmental and disease-associated processes, proving to be crucial protagonists in many physiological and pathological mechanisms. The ability of MMPs to alter, by limited proteolysis and through the fine control of tissue inhibitors of metalloproteinases, the activity or function of numerous proteins, enzymes, and receptors suggests that they are also involved in various important cellular functions during development. In this review, we focus on the differentiation of mesenchymal stem cells (including those of the myoblastic, osteoblastic, chondroblastic, neural, and apidoblastic lineages) and the possible, if unexpected, biological significance of MMPs in its regulation. The MMP system has been implicated in several differentiation events that suggests that it mediates the proliferative and prodifferentiating effect of the matrixin proteolytic cascade. We summarize these regulatory effects of MMPs on the differentiation of mesenchymal stem cells and hypothesize on the function of MMPs in the stem cell differentiation processes.

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