Stem Cells International
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Molecular BiologyCell Biology
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Các bài báo tiêu biểu
Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy
Tập 2016 Số 1 - 2016
Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant
phenotypes have been identified in many human malignancies. Based on the
properties they share with nonneoplastic stem cells or their ability to initiate
and propagate tumors in vivo, such cells were designated as cancer stem
(stem‐like) or tumor initiating/propagating cells. Owing to their implication in
treatment res...
Mesenchymal Stem Cells Derived from Dental Pulp: A Review
Tập 2016 Số 1 - 2016
The mesenchymal stem cells of dental pulp (DPSCs) were isolated and
characterized for the first time more than a decade ago as highly clonogenic
cells that were able to generate densely calcified colonies. Now, DPSCs are
considered to have potential as stem cell source for orthopedic and oral
maxillofacial reconstruction, and it has been suggested that they may have
applications beyond the scope o...
MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction
Tập 2018 - Trang 1-11 - 2018
Background. To cure ischemic diseases, angiogenesis needs to be improved by
various strategies in ischemic area. Considering that microRNA-132 (miR-132)
regulates endothelial cell behavior during angiogenesis and the safe and
efficacious delivery of microRNAs in vivo is rarely achieved, an ideal vehicle
for miR-132 delivery could bring the promise for ischemic diseases. As a natural
carrier of bio...
An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
Tập 2017 - Trang 1-17 - 2017
For decades, lipid droplets have been considered as the main cellular organelles
involved in the fat storage, because of their lipid composition. However, in
recent years, some new and totally unexpected roles have been discovered for
them: (i) they are active sites for synthesis and storage of inflammatory
mediators, and (ii) they are key players in cancer cells and tissues, especially
in cancer ...
Mesenchymal Stem Cell‐Based Therapy for Kidney Disease: A Review of Clinical Evidence
Tập 2016 Số 1 - 2016
Mesenchymal stem cells form a population of self‐renewing, multipotent cells
that can be isolated from several tissues. Multiple preclinical studies have
demonstrated that the administration of exogenous MSC could prevent renal injury
and could promote renal recovery through a series of complex mechanisms, in
particular via immunomodulation of the immune system and release of paracrine
factors and...
Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy
Tập 2017 - Trang 1-14 - 2017
Intercellular communications play a major role in tissue homeostasis and
responses to external cues. Novel structures for this communication have
recently been described. These tunneling nanotubes (TNTs) consist of
thin-extended membrane protrusions that connect cells together. TNTs allow the
cell-to-cell transfer of various cellular components, including proteins, RNAs,
viruses, and organelles, s...
Pluripotent Stem Cells: Current Understanding and Future Directions
Tập 2016 Số 1 - 2016
Pluripotent stem cells have the ability to undergo self‐renewal and to give rise
to all cells of the tissues of the body. However, this definition has been
recently complicated by the existence of distinct cellular states that display
these features. Here, we provide a detailed overview of the family of
pluripotent cell lines derived from early mouse and human embryos and compare
them with induced...
Advances in Adipose‐Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering
Tập 2016 Số 1 - 2016
Obesity is a complex, multifactorial disease that has been extensively
researched in recent times. Obesity is characterized by excess deposition of
adipose tissue in response to surplus energy. Despite the negative connotations
of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue
is a source of several adipokines and cytokines which have been deemed important
for both no...
Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune Response
Tập 2016 Số 1 - 2016
Mesenchymal stem cells (MSCs) have attracted the attention of researchers and
clinicians for their ability to differentiate into a number of cell types,
participate in tissue regeneration, and repair the damaged tissues by producing
various growth factors and cytokines, as well as their unique immunoprivilege in
alloreactive hosts. The immunomodulatory functions of exogenous MSCs have been
widely ...
Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
Tập 2017 - Trang 1-23 - 2017
The objective of this review is to outline existing artificial mitochondria
transfer techniques and to describe the future steps necessary to develop new
therapeutic applications in medicine. Inspired by the symbiotic origin of
mitochondria and by the cell’s capacity to transfer these organelles to damaged
neighbors, many researchers have developed procedures to artificially transfer
mitochondria ...