Stem Cells International
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Generation of Human-Induced Pluripotent Stem Cells by a Nonintegrating RNA Sendai Virus Vector in Feeder-Free or Xeno-Free Conditions
Stem Cells International - Tập 2012 - Trang 1-9 - 2012
The generation of induced pluripotent stem cells (iPSCs) from somatic cells has
enabled the possibility of providing unprecedented access to patient-specific
iPSC cells for drug screening, disease modeling, and cell therapy applications.
However, a major obstacle to the use of iPSC for therapeutic applications is the
potential of genomic modifications caused by insertion of viral transgenes in
the...
Mesenchymal Stem Cells Derived from Dental Pulp: A Review
Stem Cells International - Tập 2016 Số 1 - 2016
The mesenchymal stem cells of dental pulp (DPSCs) were isolated and
characterized for the first time more than a decade ago as highly clonogenic
cells that were able to generate densely calcified colonies. Now, DPSCs are
considered to have potential as stem cell source for orthopedic and oral
maxillofacial reconstruction, and it has been suggested that they may have
applications beyond the scope o...
An Overview of Lipid Droplets in Cancer and Cancer Stem Cells
Stem Cells International - Tập 2017 - Trang 1-17 - 2017
For decades, lipid droplets have been considered as the main cellular organelles
involved in the fat storage, because of their lipid composition. However, in
recent years, some new and totally unexpected roles have been discovered for
them: (i) they are active sites for synthesis and storage of inflammatory
mediators, and (ii) they are key players in cancer cells and tissues, especially
in cancer ...
Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy
Stem Cells International - Tập 2016 Số 1 - 2016
Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant
phenotypes have been identified in many human malignancies. Based on the
properties they share with nonneoplastic stem cells or their ability to initiate
and propagate tumors in vivo, such cells were designated as cancer stem
(stem‐like) or tumor initiating/propagating cells. Owing to their implication in
treatment res...
MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction
Stem Cells International - Tập 2018 - Trang 1-11 - 2018
Background. To cure ischemic diseases, angiogenesis needs to be improved by
various strategies in ischemic area. Considering that microRNA-132 (miR-132)
regulates endothelial cell behavior during angiogenesis and the safe and
efficacious delivery of microRNAs in vivo is rarely achieved, an ideal vehicle
for miR-132 delivery could bring the promise for ischemic diseases. As a natural
carrier of bio...
Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications
Stem Cells International - Tập 2017 - Trang 1-23 - 2017
The objective of this review is to outline existing artificial mitochondria
transfer techniques and to describe the future steps necessary to develop new
therapeutic applications in medicine. Inspired by the symbiotic origin of
mitochondria and by the cell’s capacity to transfer these organelles to damaged
neighbors, many researchers have developed procedures to artificially transfer
mitochondria ...
Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy
Stem Cells International - Tập 2017 - Trang 1-14 - 2017
Intercellular communications play a major role in tissue homeostasis and
responses to external cues. Novel structures for this communication have
recently been described. These tunneling nanotubes (TNTs) consist of
thin-extended membrane protrusions that connect cells together. TNTs allow the
cell-to-cell transfer of various cellular components, including proteins, RNAs,
viruses, and organelles, s...
Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain
Stem Cells International - Tập 2016 Số 1 - 2016
Transcranial direct current stimulation (tDCS) has been suggested as an adjuvant
tool to promote recovery of function after stroke, but the mechanisms of its
action to date remain poorly understood. Moreover, studies aimed at unraveling
those mechanisms have essentially been limited to the rat, where tDCS activates
resident microglia as well as endogenous neural stem cells. Here we studied the
eff...
Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation
Stem Cells International - Tập 2017 - Trang 1-17 - 2017
Pulsed electromagnetic fields (PEMFs) have been documented to promote bone
fracture healing in nonunions and increase lumbar spinal fusion rates. However,
the molecular mechanisms by which PEMF stimulates differentiation of human bone
marrow stromal cells (hBMSCs) into osteoblasts are not well understood. In this
study the PEMF effects on hBMSCs were studied by microarray analysis. PEMF
stimulatio...
Advances in Adipose‐Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering
Stem Cells International - Tập 2016 Số 1 - 2016
Obesity is a complex, multifactorial disease that has been extensively
researched in recent times. Obesity is characterized by excess deposition of
adipose tissue in response to surplus energy. Despite the negative connotations
of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue
is a source of several adipokines and cytokines which have been deemed important
for both no...
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