SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism Tập 18 Số 5 - Trang 1809-1821 - 2022
Romy Kronstein‐Wiedemann, Marlena Stadtmüller, Sofia Traikov, Mandy Georgi, Madeleine Teichert, Hesham K. Yosef, Jan Wallenborn, Andreas Karl, Karin Schütze, Michael Wagner, Ali El‐Armouche, Torsten Tonn
Abstract Background SARS-CoV-2 infection causes acute respiratory distress,
which may progress to multiorgan failure and death. Severe COVID-19 disease is
accompanied by reduced erythrocyte turnover, low hemoglobin levels along with
increased total bilirubin and ferritin serum concentrations. Moreover, expansion
of erythroid progenitors in peripheral blood together with hypoxia, anemia, and
coagul... hiện toàn bộ
Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics - 2020
Neerada Meenakshi Warrier, Prasoon Agarwal, Praveen Kumar
AbstractSurvivin is one of the rare proteins that is differentially expressed in
normal and cancer cells and is directly or indirectly involved in numerous
pathways required for tumor maintenance. It is expressed in almost all cancers
and its expression has been detected at early stages of cancer. These traits
make survivin an exceptionally attractive target for cancer therapeutics. Even
with thes... hiện toàn bộ
Generation of Human iPSC-Derived Astrocytes with a mature star-shaped phenotype for CNS modeling Tập 18 - Trang 2494-2512 - 2022
Dimitrios Voulgaris, Polyxeni Nikolakopoulou, Anna Herland
The generation of astrocytes from human induced pluripotent stem cells has been
hampered by either prolonged differentiation—spanning over two months—or by
shorter protocols that generate immature astrocytes, devoid of salient mature
astrocytic traits pivotal for central nervous system (CNS) modeling. We directed
stable hiPSC-derived neuroepithelial stem cells to human iPSC-derived Astrocytes
(hiA... hiện toàn bộ